Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Malignant neoplasm of urinary bladder
0.690 Biomarker disease BEFREE Taken together, these findings suggested that ATM may be an effective target in the radiotherapy of patients with DAB2IP-deficient BCa. 28586028 2017
Malignant neoplasm of urinary bladder
0.690 Biomarker disease BEFREE ATM participates in the regulation of viability and cell cycle via ellipticine in bladder cancer. 28138703 2017
Malignant neoplasm of urinary bladder
0.690 Biomarker disease BEFREE We hypothesize that this BBN-induced RGS6 loss represents a critical hit in UBC as it irrevocably impairs the anti-proliferative actions of the ATM/p53 and RASSF1A pathways. 27713144 2016
Malignant neoplasm of urinary bladder
0.690 Biomarker disease BEFREE The ATM inhibitor KU55933 sensitizes radioresistant bladder cancer cells with DAB2IP gene defect. 25585815 2015
Malignant neoplasm of urinary bladder
0.690 Biomarker disease BEFREE Taken together, our findings established a role for ATDC as a robust pathogenic driver of bladder cancer development, identified downstream effector pathways, and implicated ATDC as a candidate biomarker and therapeutic target. 26471361 2015
Malignant neoplasm of urinary bladder
0.690 Biomarker disease BEFREE In contrast, a bladder cancer cell line cotreated with ATM and replication inhibitors progressed more slowly through S phase and showed a marked increase in apoptosis. 25043304 2015
Malignant neoplasm of urinary bladder
0.690 AlteredExpression disease BEFREE Pretreatment with genistein sensitized BDEC and bladder cancer cell lines to HCPT-induced DNA damage by the synergistic activation of ataxia telangiectasia mutated (ATM) kinase. 23365634 2013
Malignant neoplasm of urinary bladder
0.690 Biomarker disease CTD_human Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy. 24121791 2013
Malignant neoplasm of urinary bladder
0.690 GeneticVariation disease BEFREE We examined the associations between bladder cancer and 7 polymorphisms from 5 genes involved in the maintenance of genetic stability (MMR: MLH1-93G>A; BER: XRCC1--77T>C and Arg399Gln; NER:XPC Lys939Gln and PAT +/-; DSBR:ATM G5557A and XRCC7 G6721T) in 302 incident bladder cancer cases and 311 hospital controls. 22927776 2012
Malignant neoplasm of urinary bladder
0.690 GeneticVariation disease BEFREE Depletion of ATM from two cancer cell lines, including the p53-mutant UM-UC-3 bladder cancer line, rendered the cells largely unresponsive to MT-hTer-47A. 18593932 2008
Malignant neoplasm of urinary bladder
0.690 CausalMutation disease CGI
Malignant neoplasm of urinary bladder
0.690 GeneticVariation disease CLINVAR
Malignant neoplasm of urinary bladder
0.690 GenomicAlterations disease CGI