Knockdown of STIM2 inhibited the motility of breast cancer cells by inhibiting EMT via specific suppression of NFAT1 and inhibited mammary tumor metastasis in mice.
Nuclear factor of activated T cell (NFAT1) has been shown to promote melanoma growth and metastasis <i>in vivo</i> We herein aim to investigate whether NFAT1 is capable to promote melanoma growth and metastasis by influencing TAM properties.
Both MDM2 and NFAT1 are overexpressed and constitutively activated in breast cancer, particularly in advanced breast cancer, and contribute to its initiation, progression, and metastasis.
Taken together, these studies highlight a novel negative cross talk between the NFAT1- and Stat5-signaling cascades that may affect breast tumor formation, growth, and metastasis.