NFE2L2, nuclear factor, erythroid 2 like 2, 4780

N. diseases: 823; N. variants: 34
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018801
Disease: Heart failure
Heart failure
0.370 AlteredExpression disease BEFREE Therefore, the cardioprotective effect of KF is attributed to the regulation of Nrf2, nuclear factor kappa-light-chain-enhancer of activated B cells, and Akt/GSK-3β signaling pathways in HF-induced diabetic rats. 30864233 2019
CUI: C0018801
Disease: Heart failure
Heart failure
0.370 Biomarker disease BEFREE We conclude that Nrf2 in the RVLM may be an important target for controlling sympathetic outflow in heart failure. 31556830 2019
CUI: C0018801
Disease: Heart failure
Heart failure
0.370 Biomarker disease BEFREE However, due to its peculiar ability in Nrf2 activation, SFN is recognized as an activator of Nrf2 and recommended as a supplementation for prevention and/or treatment of disorders like neoplasm and heart failure. 30858063 2019
CUI: C0018801
Disease: Heart failure
Heart failure
0.370 Biomarker disease BEFREE In conclusion, the disruption of central antioxidant property of Nrf2 worsened circulatory homeostasis with baroreflex dysfunction in heart failure. 29495326 2018
CUI: C0018801
Disease: Heart failure
Heart failure
0.370 Therapeutic disease CTD_human In addition, Nrf2 KO mice show biomarkers of heart failure, such as elevated levels of β-MHC, ANF, and BNP mRNA in the myocardium. 28373008 2017
CUI: C0018801
Disease: Heart failure
Heart failure
0.370 AlteredExpression disease BEFREE Preserving the NFE2L2 activity arrested the mitochondrial and cardiac oxidative stress, cardiac fibrosis, and heart failure in Chagas disease.Antioxid.Redox Signal.27, 550-566. 28132522 2017
CUI: C0018801
Disease: Heart failure
Heart failure
0.370 Biomarker disease BEFREE In addition, Nrf2 KO mice show biomarkers of heart failure, such as elevated levels of β-MHC, ANF, and BNP mRNA in the myocardium. 28373008 2017
CUI: C0018801
Disease: Heart failure
Heart failure
0.370 AlteredExpression disease BEFREE The purpose of this review is to summarize evidence that activation of Nrf2 enhances endogenous antioxidant defenses and counteracts oxidative stress-associated cardiac remodeling and HF. 25101151 2014