Kidney Failure, Acute
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings indicate that farrerol can effectively activate Nrf2 and can serve as a therapeutic target in the treatment of acute kidney injury (AKI).
|
31849693 |
2019 |
Kidney Failure, Acute
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
CA prevented MTX-induced AKI through activation of Nrf2/ARE/HO-1 signaling, and attenuation of ROS-induced activation of NF-κB/NLRP3 inflammasome signaling.
|
31037316 |
2019 |
Kidney Failure, Acute
|
0.400 |
Biomarker
|
disease |
BEFREE |
Nrf2 Plays a Protective Role Against Intravascular Hemolysis-Mediated Acute Kidney Injury.
|
31333462 |
2019 |
Kidney Failure, Acute
|
0.400 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to investigate the effects of bardoxolone methyl (BM), a nuclear factor erythroid 2-related factor 2 (Nrf2) activator, on acute kidney injury in a rat model of crush syndrome model.
|
31471671 |
2019 |
Kidney Failure, Acute
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Ergo, our findings suggest that GSK3β-mediated Keap1-independent regulation of Nrf2 may serve as an actionable therapeutic target for modifying the long-term sequelae of AKI.
|
31349118 |
2019 |
Kidney Failure, Acute
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These findings indicate that ALA exerts its antioxidant activity via Nrf2-associated antioxidant factors to provide a renoprotective effect against rhabdomyolysis-induced AKI.
|
29068550 |
2019 |
Kidney Failure, Acute
|
0.400 |
Biomarker
|
disease |
BEFREE |
To explore the effect of PI3K/Nrf2 pathway on acute kidney injury (AKI) induced by endotoxic shock in rats by construction of the endotoxic shock rat model.
|
30178867 |
2018 |
Kidney Failure, Acute
|
0.400 |
Biomarker
|
disease |
BEFREE |
OIP (i) activates the cytoprotective Nrf2, but not the P21, pathway; (ii) suppresses post-ischemic P21 induction and renal senescence; and (iii) confers marked protection against ischemic ARF.
|
29522116 |
2018 |
Kidney Failure, Acute
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study investigated the possible renoprotective effect of telluric acid (TEL) against lipopolysaccharide (LPS)-induced acute kidney injury (AKI) in mice, targeting toll-like receptor 4 (TLR4), phosphoinositide 3-kinase (PI3K)/Akt, and nuclear factor-erythroid 2-related factor-2 (Nrf2) pathways as possible mechanistic contributors to TEL's effect.AKI was induced by LPS (2 mg/kg).TEL (60 μg/kg; i.p.) was administered once daily for seven consecutive days before LPS injection.
|
28685413 |
2017 |
Kidney Failure, Acute
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Exogenous αKlotho increases endogenous anti-oxidative capacity partly via activation of the Nrf2 pathway to protect lungs against injury caused by direct hyperoxia exposure or AKI.
|
28347910 |
2017 |
Kidney Failure, Acute
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings showed the novel transcriptional role of miR140-5p in the expression of Nrf2 and miR-140-5p protected against Cisplatin induced oxidative stress by activating Nrf2-dependent antioxidant pathway, providing a potentially therapeutic target in acute kidney injury.
|
28928081 |
2017 |
Kidney Failure, Acute
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Genetic or pharmacological enhancement of NRF2 activity in the renal tubules significantly ameliorates damage related to AKI and prevents AKI progression to chronic kidney disease (CKD) by reducing oxidative stress.
|
28502971 |
2017 |
Kidney Failure, Acute
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, Nrf2 may be a promising therapeutic target for preventing acute kidney injury to chronic kidney disease transition.
|
27789056 |
2017 |
Kidney Failure, Acute
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these results suggested that AKI induced by MIR in diabetic rats may be associated with activation of the DJ-1/Nrf2 pathway.
|
29104636 |
2017 |
Kidney Failure, Acute
|
0.400 |
Biomarker
|
disease |
BEFREE |
We have analyzed numerous findings showing that Nrf2 induction protects against oxidative stress and modulates inflammation in acute kidney injury and chronic kidney disease progression.
|
28494744 |
2017 |
Kidney Failure, Acute
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
SnPP specifically accumulates within proximal tubule cells; transient "catalytic" Fe overload and oxidative stress result; Nrf2-cytoprotective pathways are upregulated; and these changes help protect against ischemic AKI.
|
28586635 |
2017 |
Kidney Failure, Acute
|
0.400 |
Biomarker
|
disease |
CTD_human |
Hepatic sulfotransferase as a nephropreventing target by suppression of the uremic toxin indoxyl sulfate accumulation in ischemic acute kidney injury.
|
24958931 |
2014 |