NGF, nerve growth factor, 4803

N. diseases: 616; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE Here we performed long-term evaluation of allodynia and hyperalgesia in a CCI model, and evaluated the effects of NGF and SP on the peripheral and central nervous systems. 28685530 2017
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 AlteredExpression phenotype BEFREE Pressure stimulation, contact heat stimulation, hyperalgesia (pinprick stimulation) and allodynia (brush stimulation) to mechanical stimulation were performed in the area where capsaicin and NGF were injected. 29498480 2018
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 GeneticVariation phenotype BEFREE Intramuscular injection of nerve growth factor (NGF) causes muscle hyperalgesia without immediate pain. 30513347 2019
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE Nerve growth factor is an inflammatory mediator that induces long-lasting hyperalgesia, which can partially be attributed to nerve growth factor-induced sensitization of primary afferent nociceptors. 30387376 2019
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE This means that NGF-induced hyperalgesia can occur in the absence of the p75 receptor and suggests that the trkA receptor is sufficient to mediate the acute noxious action of NGF. 9835221 1998
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 AlteredExpression phenotype BEFREE Therefore, this study investigated the effect of NGF on ASIC3 expression in the TNC and the role of NGF signaling in chemical dural stimulation-induced hyperalgesia. 30553789 2019
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 GeneticVariation phenotype BEFREE Local injection of nerve growth factor (3 µg/50 µl) or the TRPV1 agonist capsaicin (1 μg/50 μl), but not neurotrophin-3 injection (1 µg/50 µl), resulted in long-lasting facial heat hyperalgesia, which was both significantly reduced by previous neurotrophin-3 local treatment. 31577558 2020
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE Hyperalgesia developed after NGF injection in the infrapatellar fat pad, but it was not facilitated by acid provocation. 27634419 2017
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE Local pre-treatment with anti-NGF or K252a was effective to prevent ET-1 induced heat hyperalgesia. 28865353 2017
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE Intraplantar injection of NGF<sup>R100W</sup> into adult rats induced neither TrkA-mediated thermal nor mechanical acute hyperalgesia, but retained the ability to induce chronic hyperalgesia based on agonism for TrkA signaling. 29483280 2018
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE Nerve growth factor (NGF) injected into the human skin causes local hyperalgesia to mechanical and electrical stimuli lasting for weeks. 29140928 2018
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE ZMIZ1 has previously been associated with several autoimmune diseases, and NGF plays a key role in the generation of pain and hyperalgesia and has been associated with migraine. 28447608 2017
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE This study utilized two established human models of cutaneous nociceptive sensitization to explore how pre-established inflammatory hyperalgesia (ultraviolet-B-irradiation; "UVB") and non-inflammatory neurotrophic pain sensitization (nerve growth factor; "NGF") alter sensitivity to chemical and mechanically evoked itch. 29406574 2018
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE Nerve growth factor (NGF) has been implicated in hyperalgesia by sensitising nociceptors. 31383364 2019
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 AlteredExpression phenotype BEFREE This study aimed to investigate the relationship between the dynamic expression of NGF in dorsal horn and dorsal root ganglion (DRG) of diabetic rats and hyperalgesia and allodynia in diabetic neuropathic pain. 28535564 2017
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE Nerve growth factor-induced muscle hyperalgesia facilitates ischaemic contraction-evoked pain. 31314952 2019
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE Development of hyperalgesia may be associated with an increase in NGF as well as increased inflammatory mediators. 31152170 2019
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE A dipeptide mimetic of NGF loop 4, bis(N-succinyl-L-glutamyl-L-lysine) hexamethylenediamide (GK-2), developed at the Zakusov Research Institute of Pharmacology, has the NGF-like ability to activate TrkA receptors, but unlike NGF, GK-2 activates mainly the PI3K/AKT pathway associated with neuroprotection and has no effect on the MAPK cascade associated with hyperalgesia, the main side effect of NGF. 31720014 2020
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE Since that time, NGF has also been shown to play a key role in the generation of acute and chronic pain and in hyperalgesia in diverse pain states. 23157347 2013
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype CTD_human To confirm that the remaining, TrkA(+)/IB4(-), nociceptors are still functional, we evaluated if nerve growth factor (NGF) induced hyperalgesia. 20457222 2010
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Therapeutic phenotype RGD Neural mobilization reverses behavioral and cellular changes that characterize neuropathic pain in rats. 22839415 2012
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype RGD Blockade of NGF and trk receptors inhibits increased peripheral mechanical sensitivity accompanying cystitis in rats. 18448607 2008
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype RGD Brain-derived neurotrophic factor increases in the uninjured dorsal root ganglion neurons in selective spinal nerve ligation model. 11425916 2001