NGF, nerve growth factor, 4803

N. diseases: 616; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.070 Biomarker disease BEFREE We also find that Bmf co-operates with other important BH3-only proteins such as Bim and Puma in neuron death induced by or NGF deprivation. 29499358 2018
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.070 Biomarker disease BEFREE Alzheimer's disease (AD) models were established by injecting Aβ(1-42) into the rat hippocampus and the effects of learning and memory were observed by a Morris water maze test, immunohistological alterations, and correlative indicators covering nerve growth (brain-derived neurotrophic factor, glial-cell-derived trophic factor, and nerve growth factor), interleukin 1β, tumor necrosis factor, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA), glial fibrillary acidic protein (GFAP), and microglial CD11b in AD rats. 29714500 2018
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.070 Biomarker disease BEFREE Minocycline also reversed the increase in the levels of Brain-derived neurotrophic factor (BDNF) in the hippocampus caused by (1-42), and reduced Nerve Growth Factor (NGF) increases in the total cortex. 28336494 2017
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.070 Biomarker disease BEFREE Finally, we recapitulate our recent in-vitro evidence for the involvement of neurotrophin nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in the neuroprotective effect elicited by NPY in AD neuron-like models (neuroblastoma cells or primary cultures exposed to toxic concentrations of 's pathogenic fragment 25-35), and propose a putative mechanism based on NPY-induced inhibition of voltage-dependent Ca(2+) influx in pre- and post-synaptic neurons. 25026432 2014
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.070 Biomarker disease BEFREE In this study, we observed whether NGF can affect cholinergic neurons to change amyloid-β precursor protein (APP) metabolism process and reduce amyloidosis in AD brains. 24813062 2014
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.070 AlteredExpression disease BEFREE In conclusion, MEM treatment activated the NGF/TrkA signaling, and inhibited the p75(NTR) signaling in APP/PS1 mice to ameliorate the behavioral deficits and amyloidosis, indicating that NGF signaling was a new potential target of MEM treatment for AD therapy. 24846616 2014
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.070 Biomarker disease BEFREE To determine the occurrence of key inflammatory markers and to look for signs of nerve growth factor (NGF) dysmetabolism at preplaque and postplaque stages in tg models of AD-like amyloid pathology and in human AD brains. 22261363 2012