NGF, nerve growth factor, 4803

N. diseases: 616; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002768
Disease: Congenital Pain Insensitivity
Congenital Pain Insensitivity
0.320 GeneticVariation disease BEFREE Recent studies have revealed that mutations in the NGFB gene-encoding NGF protein also cause congenital insensitivity to pain. 22882139 2012
CUI: C0002768
Disease: Congenital Pain Insensitivity
Congenital Pain Insensitivity
0.320 Biomarker disease BEFREE There is evidence that the nociceptive (and sympathetic) axons die because nerve growth factor is not being produced by the target tissues; patients with congenital insensitivity to pain have mutations in the NTRK1 gene, the gene responsible for producing the TrkA receptor, but there is also evidence for mutations in the SCN9A gene, which codes for a specific subunit of the voltage-gated sodium channel. 19593630 2009
CUI: C0002768
Disease: Congenital Pain Insensitivity
Congenital Pain Insensitivity
0.320 GermlineCausalMutation disease ORPHANET A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception. 14976160 2004