|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
NGF deficiency is one of the reasons for reduced β-cells survival in diabetes.
|
31385776 |
2020 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have previously shown that diabetes causes an imbalance of nerve growth factor (NGF) isoforms resulting in accumulation of its precursor proNGF and upregulation of the p75 neurotrophin receptor (p75<sup>NTR</sup>), with consequent increases in the activation of Ras homologue gene family, member A (RhoA).
|
31073629 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pre-emptive gene therapy with NGF prevented bone marrow denervation, contrasting with the inhibitory effect of diabetes on the mobilisation of NK1R-expressing stem cells, and restored blood flow recovery from limb ischaemia.
|
31016359 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Impact of intranasal application of nerve growth factor on the olfactory epithelium in rats with chemically induced diabetes.
|
29693500 |
2018 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Vildagliptin treatment also reversed diabetes-induced decreases in phosphorylated (p)-protein kinase B (Akt) and p-glycogen synthase kinase 3β (GSK3β), brain-derived neurotrophic factor and nerve growth factor expression levels.
|
29805536 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
NGF is involved in psychological processes and may be the possible therapeutical agent for diabetes, cancer and cardiovascular diseases, which will be described in the article.
|
30030957 |
2018 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Increased gene expression level of GLP-1 receptor and NGF may underlie the beneficial action of exenatide in STZ/NA-induced diabetes.
|
29091313 |
2018 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The course of diabetes should be much longer and there is not a precise analysis of the quantitative relation between the NGF expression in the dorsal horn/DRG and hyperalgesia/allodynia.
|
28535564 |
2017 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
After having established that diabetes reduces cardiac NGF mRNA expression, we tested NGF gene therapies with adeno-associated viral vectors (AAVs) for the capacity to protect the diabetic mouse heart.
|
22187379 |
2012 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the present study, serum, pancreas islets and spleen mononuclear cells from NOD mice treated with monosialic ganglioside GM1 (100 mg/kg/day) and the group control which received saline solution were isolated to investigate the proinflammatory cytokines (IL-1beta, IFN-gamma, IL-12, TNF-alpha), NGF and its high-affinity receptor TrkA, peri-islet Schwann cells components (GFAP, S100-beta) expression and the relationship with diabetes onset and morphological aspects.
|
18329889 |
2008 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the causal role of peroxynitrite and the impact of tyrosine nitration on diabetes-induced retinal neurodegeneration and NGF survival signaling have not been elucidated.
|
18285558 |
2008 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study was conducted to (i) assess the statement of NGF system components in diabetic wounds and (ii) evaluate whether NGF supplementation could prevent impairment of wound neoangiogenesis by diabetes.
|
15164170 |
2004 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Diabetes-induced deficits in retrograde transport of nerve growth factor and sciatic-nerve levels of calcitonin gene-related product and neuropeptide Y were also ameliorated by treatment with the sonic hedgehog-IgG fusion protein, as was thermal hypoalgesia in the paw.
|
12588889 |
2003 |