NGF, nerve growth factor, 4803

N. diseases: 616; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.360 Biomarker disease BEFREE These results demonstrate neuroinflammation, as well as negative regulation of neurotrophic factors (GDNF and NGF), may be involved in aminochrome-induced neurodegeneration, and they contribute to a better understanding of PD pathogenesis. 29588162 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.360 AlteredExpression disease BEFREE The aim of the present study was to investigate whether PACA could increase NGF levels against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) neurotoxicity in a mouse PD model. 28321769 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.360 Biomarker disease BEFREE Synthetic peptides that can act as NGF receptor agonists (NGF mimetics) are known to attenuate neurodegenerative pathologies in experimental models of Alzheimer's disease and Parkinson's disease; however, the existence of plant-based NGF mimetics is uncertain. 29955238 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.360 Biomarker disease BEFREE The glial cell line-derived neurotrophic factor (GDNF), one of the most potent useful neurotrophic factors for the treatment of Parkinson's disease (PD), is firstly synthesized as the proform (proGDNF) like other neurotrophin NGF, BDNF, and NT3. 23934644 2014
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.360 GeneticVariation disease BEFREE Genetic studies have identified numerous factors linking β-adrenergic blockade to Parkinson's disease (PD), including human leukocyte antigen genes, the renin-angiotensin system, poly(adenosine diphosphate-ribose) polymerase 1, nerve growth factor, vascular endothelial growth factor, and the reduced form of nicotinamide adenine dinucleotide phosphate. 23695225 2013
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.360 AlteredExpression disease BEFREE IGF-I and IGF-II resistance was present in DLB but not PD frontal cortex, and associated with reduced expression of Hu, nerve growth factor, and Trk neurotrophin receptors, and increased levels of glial fibrillary acidic protein, alpha-synuclein, dopamine-beta-hydroxylase, 4-hydroxy-2-nonenal (HNE), and ubiquitin immunoreactivity. 19276553 2009
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.360 Biomarker disease CTD_human IGF-I and IGF-II resistance was present in DLB but not PD frontal cortex, and associated with reduced expression of Hu, nerve growth factor, and Trk neurotrophin receptors, and increased levels of glial fibrillary acidic protein, alpha-synuclein, dopamine-beta-hydroxylase, 4-hydroxy-2-nonenal (HNE), and ubiquitin immunoreactivity. 19276553 2009