|
Central neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
The results of our study indicate that NGF protects neuroblastoma against injury triggered by Aβ25-35 via suppression of ROS-JNK/c-Jun pathway stimulation through the Nrf2/HO-1 pathway.
|
31605506 |
2019 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Notably, we identified the estrogen-NGF crosstalk, as well as a set of other NHRs, as potential prognostic markers and targets for therapeutic strategies against NB.
|
29374092 |
2018 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we investigated the regulation of TG2 transamidase activity by NGF in retinoic acid-induced differentiating mouse N2a and human SH-SY5Y neuroblastoma cells.
|
29242118 |
2018 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pretreatment with AITC significantly inhibited inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression, decreased tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), prostaglandin E2 (PGE2), and nitric oxide (NO) production in activated microglia, and increased the nerve growth factor (NGF) and neurite outgrowth in neuroblastoma cells.
|
28671636 |
2017 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We performed a time-resolved analysis of NGF-TrkA signaling in neuroblastoma cells using mass spectrometry-based quantitative proteomics.
|
25921289 |
2015 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
KIF1B is a candidate tumor-suppressor gene in neuroblastoma whose function is to mediate apoptosis when nerve growth factor becomes limiting in the developing nervous system.
|
24706657 |
2014 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, we recapitulate our recent in-vitro evidence for the involvement of neurotrophin nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in the neuroprotective effect elicited by NPY in AD neuron-like models (neuroblastoma cells or primary cultures exposed to toxic concentrations of Aβ's pathogenic fragment 25-35), and propose a putative mechanism based on NPY-induced inhibition of voltage-dependent Ca(2+) influx in pre- and post-synaptic neurons.
|
25026432 |
2014 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pheochromocytoma and neuroblastoma arise from neural crest progenitors that compete for growth factors such as nerve growth factor (NGF) during development.
|
24469107 |
2014 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data suggest that UNC5D forms a positive feedback loop with p53 and E2F1 to promote NGF dependence-mediated PCD during NB regression.
|
23778138 |
2013 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The LPCX retroviral vector was used to achieve stable transduction of NGF complementary DNA into BE(2)C neuroblastoma cells.
|
21683221 |
2011 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Forced re-expression of endogenous TRKA and p75NTR with exposure to the HDAC inhibitor TSA sensitized neuroblastoma cells to NGF-mediated apoptosis.
|
21123453 |
2011 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We isolated and characterized an HUCB-derived population of progenitors (HUCBNP), differentiated toward neuronal phenotype by human neuroblastoma-conditioning medium (CM) and nerve growth factor (NGF), which have been found to confer neuroprotection toward hypoxia-mediated neuronal injury.
|
19458627 |
2009 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In vitro differentiation of the HUCBNPs was achieved by treatment with 10% human SH-SY5Y neuroblastoma cell-conditioning media (CM) supplemented with 10 ng/ml nerve growth factor (NGF).
|
17873363 |
2007 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data suggest that CPPy can induce the differentiation of NB cell lines by facilitating NGF-induced TrkA/Ras/MAPK signal transduction, and may therefore be an effective therapeutic agent for NB.
|
17409494 |
2007 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present studies are designed to examine if huperzine A exerts its neuroprotective activity against oxidative stress damage through increasing the synthesis of NGF in SHSY5Y neuroblastoma cells.
|
16111675 |
2005 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Differences in gene expression profile among SH-SY5Y neuroblastoma subclones with different neurite outgrowth responses to nerve growth factor.
|
15992370 |
2005 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
TrkAIII exhibits neuroblastoma xenograft tumor-promoting activity associated with the induction of a more angiogenic and stress-resistant neuroblastoma phenotype and antagonises nerve growth factor/TrkAI antioncogenic signaling.
|
16556046 |
2005 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this report, we detail mechanisms by which nerve growth factor (NGF) decreases N-myc levels in TrkA-transfected NB cells and its effect on NB cell proliferation.
|
14691455 |
2004 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Both low- and high-affinity NGF receptors were expressed in perinatal neuroblast hyperplasia but not in neuroblastoma tumor tissue.
|
15314226 |
2004 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results show that c-Jun/AP-1, through up-regulation of NCAM140, plays an important role in both NGF-induced neuronal differentiation and resistance to apoptosis induced by NO in neuroblastoma cells.
|
12101231 |
2002 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of exogenous trkA in neuroblastoma cells restores their ability to differentiate in response to nerve growth factor (NGF).
|
11205744 |
2001 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have studied nerve growth factor (NGF) receptors in 63 neuroblastoma tissues.
|
10200344 |
1999 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression level of trkA tyrosine kinase receptor for nerve growth factor is a major prognostic determinant of neuroblastoma, suggesting that defective trkA-mediated signaling is responsible for the tumorigenesis of this childhood malignancy.
|
10462038 |
1999 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
SK-N-BE neuroblastoma cell clones transfected with p75(NTR) and lacking Trk neurotrophin receptors, previously reported to undergo extensive spontaneous apoptosis and to be protected by nerve growth factor (NGF) (Bunone, G., Mariotti, A., Compagni, A., Morandi, E., and Della Valle, G. (1997) Oncogene 14, 1463-1470), are shown to exhibit (i) increased levels of the pro-apoptotic lipid metabolite ceramide and (ii) high activity of caspases, the proteases of the cell death cascade.
|
10336437 |
1999 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collaborative and reciprocal effects of ciliary neurotrophic factor and nerve growth factor on the neuronal phenotype of human neuroblastoma cells.
|
9523557 |
1998 |