If the gut microbiota differences among AD and PDD-NOS and HC children are one of the concomitant causes or the consequence of autism, they may have implications regarding specific diagnostic test, and/or for treatment and prevention.
Approximately three-fourths of the children with SLOS (71-86% depending on the evaluation method) had an ASD, about 50% diagnosed with Autistic Disorder and the rest with PDD NOS.
Given the relatively high yield of genetic diagnoses in this population, we believe that children with PDD-NOS or AD should have a detailed evaluation by a clinical geneticist or pediatrician trained in dysmorphology.