NOS2, nitric oxide synthase 2, 4843

N. diseases: 783; N. variants: 28
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.360 AlteredExpression disease BEFREE Increased mineralocorticoid activity accounts for increased NO production, iNOS gene and protein expression but does not explain the increased basal reactive oxygen species production and decreased markers of alternative activation in “heart failure” macrophages. 24486397 2014
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.360 Biomarker disease BEFREE In anesthetized rats, AdACE2 treatment attenuated the responses of renal sympathetic nerve activity (RSNA), mean arterial pressure, and heart rate to the NOS inhibitor N-monomethyl-L-arginine in rats with CHF (RSNA: 28 ± 3% vs. 16 ± 3%, P < 0.05) compared with CHF + AdEGFP group. 21963832 2011
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.360 Biomarker disease CTD_human NOS inhibition by L-NAME increased basal frequency and attenuated the positive chronotropic effect of beta-adrenergic stimulation in the HF group (P<0.05). 19168511 2009
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.360 AlteredExpression disease BEFREE Inducible NO synthase is expressed in human skeletal muscle and its gene expression is increased in patients with severe heart failure. 9768718 1998
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.360 AlteredExpression disease BEFREE However, data on myocardial NOS expression in heart failure are conflicting. 9809923 1998
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.360 AlteredExpression disease BEFREE Because autoimmune myocarditis can develop in animals lacking IRF-1, these mice will be useful to elucidate the link between iNOS expression in inflammatory heart disease and the development of dilated cardiomyopathy and heart failure. 9244230 1997
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.360 Biomarker disease BEFREE Western blot analysis with the same primary antibody showed a specific positive band for iNOS protein in the heart failure specimens; minimal iNOS protein expression was seen in donor heart samples. 8653828 1996