NOS2, nitric oxide synthase 2, 4843

N. diseases: 783; N. variants: 28
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE In vivo investigation showed that γ-GC reduced sepsis lethality and attenuated systemic inflammatory responses in mice, as well as inhibited lipopolysaccharide (LPS)-stimulated production of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), high-mobility group box 1 (HMGB1), and nitric oxide (NO) and the expression of inducible NO synthase and cyclooxygenase 2 in RAW264.7 cells. 30326393 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE This study clearly highlights the NOS2-dependent and -independent responses in this mouse model of peritonitis induced sepsis. 29309892 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE Pretreatment with ZSCLE (100, 200, and 300 mg/kg) restored the normal heart rate (HR); decreased the elevated levels of malondialdehyde; the activity of myeloperoxidase, nitric oxide (NO), and inducible NO synthase; and the expression of nuclear factor kappa B (NF-κB), but increased the content of glutathione and antioxidant enzyme activities in mice with sepsis. 29549730 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE Sepsis increased NOS2 expression in the heart, increased plasma nitrite + nitrate levels, and reduced isoproterenol-induced isolated ventricle contraction, whole heart tension development, and β-adrenergic receptor density. 28526706 2017
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE NOS isoform activation is related to liver failure during sepsis, but the mechanisms driving mitochondrial impairment remain unclear. 28110436 2017
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 GeneticVariation disease BEFREE Sepsis independently associated with HF, increased NOx, peripheral neutrophils, and fibrinogen levels, decreased prothrombin and the presence of the NOS3 (E298D) and NOS2A (exon 22) SNPs. 25239655 2014
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 GeneticVariation disease BEFREE In this study, we assessed whether SNPs within NOS2 gene were associated with severity of sepsis in Chinese populations. 23192595 2013
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease CTD_human Essential role of nitric oxide in sepsis-induced impairment of endothelium-derived hyperpolarizing factor-mediated relaxation in rat pulmonary artery. 20035746 2010
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease CTD_human Down-regulation of CXCR2 on neutrophils in severe sepsis is mediated by inducible nitric oxide synthase-derived nitric oxide. 17138957 2007
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE Little is known about transcriptional regulation of the human iNOS gene in vivo under basal conditions or in sepsis. 15507544 2005
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE For instance, NO potentiates the hepatic oxidative injury in warm ischemia/reperfusion, while iNOS expression protects against hepatic apoptotic cell death seen in models of sepsis and hepatitis. 14527083 2003
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE These results suggest that TXA2 has a protective role against the development of vascular hyporesponsiveness via its inhibitory action on the iNOS-NO system under pathological conditions such as sepsis. 14557367 2003