NOS2, nitric oxide synthase 2, 4843

N. diseases: 783; N. variants: 28
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.560 AlteredExpression group BEFREE 0 or 6 h after MCAO, and assessed stroke volume and NOS2 expression in BMVECs 24 h following MCAO in rats. 30405345 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.560 Biomarker group BEFREE Animal studies have allowed important insights into the role of the nitric oxide synthase (NOS) enzymes in atherosclerosis and hypertension, as well as in stroke. 22153699 2012
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.560 Biomarker group CTD_human SO2 inhalation contributes to the development and progression of ischemic stroke in the brain. 20083630 2010
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.560 Biomarker group RGD Dynamics of neuroinflammation in the macrosphere model of arterio-arterial embolic focal ischemia: an approximation to human stroke patterns. 21171972 2010
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.560 GeneticVariation group LHGDN Long-term survival after ischemic stroke in postmenopausal women is affected by an interaction between smoking and genetic variation in nitric oxide synthases. 18648197 2008
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.560 AlteredExpression group BEFREE High LV endomyocardial NOS gene expression is observed in athlete's heart and in dilated cardiomyopathy with low diastolic LV stiffness and preserved LV stroke work. 12123766 2002
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.560 AlteredExpression group BEFREE Because of lower endomyocardial NOS gene expression in patients with higher functional class and lower LV stroke work, increased endomyocardial NOS gene expression seems to be beneficial rather than detrimental for the failing heart. 11309529 2001
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.560 AlteredExpression group BEFREE In patients with elevated LV end-diastolic pressure (>16 mm Hg), a closer correlation was observed between endomyocardial expression of NOS2 and LV stroke volume (P=0.001; r=0.74), LV ejection fraction (P=0.0007; r=0.77), and LV stroke work (r=0.82; P=0.0002). 10368118 1999