|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Patients with both CCAD and diffuse sinonasal polyps had an allergy prevalence approaching that of CCAD and an asthma prevalence approaching CRSwNP NOS.
|
31600866 |
2020 |
|
Asthma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Immunostaining revealed expression of iNOS proteins mainly in epithelial cells in the airways, while it was mainly expressed in macrophages in the alveolar region in the snBA group.
|
30667100 |
2019 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In vivo investigation showed that γ-GC reduced sepsis lethality and attenuated systemic inflammatory responses in mice, as well as inhibited lipopolysaccharide (LPS)-stimulated production of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), high-mobility group box 1 (HMGB1), and nitric oxide (NO) and the expression of inducible NO synthase and cyclooxygenase 2 in RAW264.7 cells.
|
30326393 |
2019 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
This review focusses on the role of arginase, NOS and ADMA in co-morbidities of asthma and COPD and speculates on their possible connection.
|
29729549 |
2018 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Also, treatment with EGb761 inhibited hypertension-induced decrease in endothelial nitric oxide synthase (eNOS) protein expression and increase in the protein expressions of inducible NO synthase (iNOS), TNF-α, IL-6 and IL-1B in the kidney tissues.
|
29351002 |
2018 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study clearly highlights the NOS2-dependent and -independent responses in this mouse model of peritonitis induced sepsis.
|
29309892 |
2018 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Pretreatment with ZSCLE (100, 200, and 300 mg/kg) restored the normal heart rate (HR); decreased the elevated levels of malondialdehyde; the activity of myeloperoxidase, nitric oxide (NO), and inducible NO synthase; and the expression of nuclear factor kappa B (NF-κB), but increased the content of glutathione and antioxidant enzyme activities in mice with sepsis.
|
29549730 |
2018 |
|
Asthma
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
In exploratory analyses, V levels were associated with lower methylation of the proinflammatory NOS2A-CpG<sup>+5099</sup> among asthmatic overweight or obese children but not nonasthmatics.
|
28424066 |
2017 |
|
Asthma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
There were no differences, however, in iNOS mRNA levels in total BAL cells in uncontrolled as compared to controlled asthma.
|
27647044 |
2017 |
|
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Nanoparticles harboring iNOS plasmids (constitutively active cytomegalovirus [CMV]-driven or transcriptionally regulated human osteocalcin [hOC]-driven) evoked iNOS protein expression and nitrite accumulation and impaired clonogenicity in the highly aggressive MDA-MB-231 human breast cancer model.
|
28325291 |
2017 |
|
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
The elucidation of these and other NO-driven pathways implicates NOS2 as a key driver of breast cancer disease progression and provides a new perspective in the identification of novel targets that may be therapeutically beneficial in the treatment of estrogen receptor-negative disease.Antioxid.Redox Signal.26, 1044-1058.
|
27464521 |
2017 |
|
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
NOS inhibitors and RNA editing modulators may offer novel treatment options for metaplastic breast cancer.
|
28040796 |
2017 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Also, EGb761 inhibited hypertension with hypercholesterolemia-induced decrease in endothelial nitric oxide synthase (eNOS) protein expression and increase in the protein expressions of inducible NO synthase (iNOS), TNF-α, IL-6 and IL-1β in the kidney tissues.
|
28915536 |
2017 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Sepsis increased NOS2 expression in the heart, increased plasma nitrite + nitrate levels, and reduced isoproterenol-induced isolated ventricle contraction, whole heart tension development, and β-adrenergic receptor density.
|
28526706 |
2017 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
NOS isoform activation is related to liver failure during sepsis, but the mechanisms driving mitochondrial impairment remain unclear.
|
28110436 |
2017 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the association of iNOS promoter gene polymorphisms and FeNO levels in Japanese asthmatics before the introduction of asthma treatment.
|
27021121 |
2016 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our study suggests that the amount of iNOS and NO are critical determinants in the modulation of AHR by selective iNOS inhibitors and renews the potential of iNOS as a therapeutic target for asthma.
|
27524861 |
2016 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
TLR4/MyD88/NF-κB signaling and PPAR-γ within the paraventricular nucleus are involved in the effects of telmisartan in hypertension.
|
27292124 |
2016 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
However, haplotype analysis of rs2779249 and rs2297518 revealed that individuals having haplotype H3 which combines both A alleles (CA-GA, 19.7% of individuals) was more commonly found in the hypertensive group than in the normotensive group (OR = 2.01; CI = 1.29-3.12; P = 0.002).In conclusion, there was a significant association between iNOS genetic variant (rs2779249) and hypertension in the genetically homogenous Finnish population.
|
26579803 |
2015 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In a cohort of 5912 adults 25-75 years of age, we investigated the relationship between NOS2 haplotypes and FENO, and effect modification by asthma.
|
24729625 |
2014 |
|
Asthma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
BNP stimulated the release of acetylcholine (210.7 ± 11.1%) from BEAS-2B cells that in turn increased MYPT1 and iNOS gene/protein expression and enhanced NO levels in asthmatic ASM supernatant (35.0 ± 13.0%).
|
24074453 |
2014 |
|
Malignant neoplasm of breast
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We evaluated dietary factors associated with oxidative balance, DDIT4 (one SNP), FLT1 (35 SNPs), HIF1A (four SNPs), KDR (19 SNPs), MPO (one SNP), NOS2A (15 SNPs), TEK (40 SNPs) and VEGFA (eight SNPs) and breast cancer risk among Hispanic (2,111 cases and 2,597 controls) and non-Hispanic white (1,481 cases and 1,586 controls) women in the Breast Cancer Health Disparities Study.
|
23832257 |
2014 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We aimed to comprehensively investigate which NOS gene variants are most strongly associated with coronary heart disease (CHD) and hypertension, using a set of tagging SNPs with good coverage across the 3 genes.
|
24713495 |
2014 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Analysis of oxidative stress enzymes and structural and functional proteins on human aortic tissue from different aortopathies.
|
25101153 |
2014 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Sepsis independently associated with HF, increased NOx, peripheral neutrophils, and fibrinogen levels, decreased prothrombin and the presence of the NOS3 (E298D) and NOS2A (exon 22) SNPs.
|
25239655 |
2014 |