NOS3, nitric oxide synthase 3, 4846

N. diseases: 706; N. variants: 39
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.400 Biomarker disease BEFREE We found that both aberrant expression and dysfunction of eNOS are closely related to AS development, and some new treatment strategies aimed at eNOS have been proposed, including upregulation of eNOS expression and inhibition of eNOS uncoupling. 30937466 2019
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.400 AlteredExpression disease BEFREE Our findings demonstrate that RSV has an effect of activating eNOS expression, contributing to the prevention of dyslipidemia-induced endothelial dysfunction and atherosclerosis. 30856465 2019
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.400 AlteredExpression disease BEFREE This suggests that eNOS deficiency may elevate aggrecan expression, which promotes apoptosis in VSMC, thereby contributing to atherosclerosis progression. 30638179 2019
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.400 GeneticVariation disease BEFREE The NOS3 G894T polymorphic variant also correlated with atherosclerosis, an association probably mediated by the traditional risk factors for CVD. 29948131 2018
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.400 PosttranslationalModification disease BEFREE All‑trans retinoic acid reduces endothelin‑1 expression and increases endothelial nitric oxide synthase phosphorylation in rabbits with atherosclerosis. 29207193 2018
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.400 Biomarker disease BEFREE Thus, we investigated whether PDCD5 regulates protein kinase B (PKB/AKT)-endothelial nitric oxide synthase (eNOS)-dependent signal transduction in the endothelium and affects atherosclerosis. 29588416 2018
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.400 AlteredExpression disease BEFREE To test whether the absence of NO may aggravate atherosclerosis through EMMPRIN activation, double NOS3/apoE knockout (KO) mice expressed high levels of EMMPRIN in carotid plaques, suggesting that targeting extracellular matrix degradation may represent a new mechanism by which endothelial NO prevents atherosclerosis. 30347750 2018
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.400 Biomarker disease BEFREE Endothelial dysfunction, which is caused by endothelial nitric oxide synthase (eNOS) uncoupling, is an initial step in atherosclerosis. 29136955 2018
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.400 Biomarker disease BEFREE Thus, the aim of our study was to use iTRAQ-based quantitative proteomics to investigate the changes in protein expression in the mitochondrial and cytosolic fractions isolated from the liver of the double (apolipoprotein E (apoE) and eNOS) knockout (apoE/eNOS-DKO) mice as compared to apoE KO mice (apoE<sup>-/-</sup> ) - an animal model of atherosclerosis and hepatic steatosis. 29485188 2018
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.400 Biomarker disease BEFREE Taken together, OJS has a protective effect on vascular inflammation via eNOS coupling-mediated NO production and might be a potential therapeutic agent for both early and advanced atherosclerosis. 30200674 2018
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.400 GeneticVariation disease BEFREE In the present study, we analyzed the G894T polymorphism of the eNOS gene in groups of individuals diagnosed with atherosclerosis and in a control group. 28481400 2017
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.400 AlteredExpression disease BEFREE ApoE<sup>-/-</sup> mice had significantly more atherosclerosis in the aortic root together with increased aortic ROS production, body mass, plasma triglyceride (TG) and total cholesterol (TC) concentration, decreased aortic eNOS expression, and plasma NO concentration. 28177681 2017
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.400 Biomarker disease BEFREE These articles described the effects of ESWT on angiogenesis, arteriogenesis, vasculogenesis, endothelial nitric oxide synthase, lower limb micro/macrocirculation, and atherosclerosis. 28688873 2017
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.400 Biomarker disease BEFREE In conclusion, XMJ recouples eNOS to prevent the growth of atherosclerosis in rats. 28252100 2017
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.400 Biomarker disease BEFREE The aim of this study is to evaluate the relationship of miR-21, nitric oxide (NOx) and endothelial nitric oxide synthase (eNOS) with subclinical atherosclerosis in carotid arteries by measuring carotid intima media thickness (CIMT) in patients with hypertension and healthy controls. 26114349 2015
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.400 GeneticVariation disease BEFREE We suggest that eNOS intron 4 gene polymorphism is related to endothelial dysfunction and subclinical atherosclerosis and could be a possible genetic marker for prediction of increased susceptibility to cardiovascular complications. 25699607 2015
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.400 Biomarker disease BEFREE Endothelial nitric oxide synthase deficiency (eNOS(-/-)) results in moderate hypertension and the development of nodular glomerulosclerosis and hyaline arteriosclerosis in streptozotocin-induced diabetic C57BL/6J mice. 25034792 2014
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.400 GeneticVariation disease BEFREE Genetic polymorphism of the endothelial nitric oxide synthase (eNOS) affects the pathogenesis of atherosclerosis and associated with premature coronary artery disease (PCAD). 23269619 2013
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.400 GeneticVariation disease BEFREE Interaction between the NOS3 gene and obesity as a determinant of risk of type 2 diabetes: the Atherosclerosis Risk in Communities study. 24278136 2013
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.400 AlteredExpression disease BEFREE Progranulin efficiently inhibited LPS-mediated pro-inflammatory signaling in endothelial cells through activation of the Akt/eNOS pathway and attenuation of the NF-κB pathway, suggesting its protective roles in vascular endothelium against inflammatory reaction underlying atherosclerosis. 24098801 2013
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.400 GeneticVariation disease BEFREE The allelic variation (Asp298) of the eNOS gene polymorphism makes individuals vulnerable to the impact of weight on the development of atherosclerosis. 22450868 2012
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.400 Biomarker disease BEFREE Our results highlight NOS1 as a susceptibility factor for stroke, but do not corroborate previous NOS3 association findings with stroke risk. nNOS is known to play a major role in atherosclerosis development and in blood flow regulation, and it is plausible that its influence in stroke may be mediated through these two main clinical risk factors. 22153699 2012
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.400 Biomarker disease BEFREE Mainly expressed in the vascular endothelium, the endothelial NOS isoform (eNOS) plays an important role in the regulation of vascular reactivity and in the development and progression of atherosclerosis. 21308339 2011
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.400 GeneticVariation disease BEFREE We hypothesized a possible mechanism for atherosclerosis in which interleukin-6 (IL-6) might affect the endothelial nitric oxide synthase (eNOS)-caveolin-1 interaction and result in decreased nitric oxide bioavailability in the setting of low-grade inflammation. 20375905 2010
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.400 GeneticVariation disease BEFREE We investigated associations between the NOS3 rs1799983" genes_norm="4846">Glu298Asp SNP (rs1799983) and hypertension, as well as the interaction between NOS3 genotypes and dietary fat intake using data from baseline examination in white and African American participants in the Atherosclerosis Risk in Community (ARIC) study. 19960019 2010