Coronary Artery Vasospasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results indicated that female sex, diabetes, and mutation in -786T/C eNOS gene correlate with ACh-provoked myocardial ischemia in patients with coronary spasm.
|
26656861 |
2015 |
Coronary Artery Vasospasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Three polymorphisms, Paraoxonase 1 (PON1) Q192R (C/G), endothelial nitric oxide synthase (eNOS) E298D (G/T) and eNOS T-786C have been suggested to be potentially associated with coronary artery spasm in Japanese patients.
|
21287574 |
2011 |
Coronary Artery Vasospasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Because the endothelial nitric oxide synthase (eNOS) T-786C polymorphism is associated with reduced nitric oxide production and coronary artery spasm in Japanese patients, we speculated that it might be reversibly associated with Prinzmetal's variant angina in white Americans.
|
20211321 |
2010 |
Coronary Artery Vasospasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Several polymorphisms in the eNOS gene have been described, some of them being linked with the increased risk of cardiovascular disease, coronary heart disease (CHD), and coronary spasm.
|
19505886 |
2009 |
Coronary Artery Vasospasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Studies have shown a link between single-nucleotide polymorphisms (SNPs) in the endothelial nitric oxide synthase (eNOS) gene and the incidence of coronary spasm and aneurysms.
|
18319732 |
2008 |
Coronary Artery Vasospasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We previously found a -786T/C polymorphism in the 5'-flanking region of the endothelial nitric oxide synthase (eNOS) gene and reported that this polymorphism is associated with coronary spasm.
|
18075462 |
2007 |
Coronary Artery Vasospasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The eNOS -786C allele is an independent risk factor for readmission due to a recurrent attack of coronary spasm in patients with coronary spasm, even if the patients have taken calcium channel blockers and/or nitrate.
|
17622934 |
2007 |
Coronary Artery Vasospasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Logistic multiple regression analysis identified the a/a or a/b genotype in intron 4 of ecNOS (NOS4a: p=0.0431, odds ratio (OR) 2.43) and diabetes mellitus (p=0.0060, OR 4.88) as significant predictors of coronary spasm.
|
16565556 |
2006 |
Coronary Artery Vasospasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The Glu298Asp polymorphism in the eNOS gene is a definite risk factor for coronary spasm, especially for diffuse coronary spasm.
|
12826928 |
2003 |
Coronary Artery Vasospasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To the authors' knowledge, she represents the first case of life-threatening coronary spasms in childhood associated with mutations in the endothelial nitric oxide synthase gene.
|
12678200 |
2003 |
Coronary Artery Vasospasm
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Synergistic interaction of T-786-->C polymorphism in the endothelial nitric oxide synthase gene and smoking for an enhanced risk for coronary spasm.
|
14583681 |
2003 |
Coronary Artery Vasospasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recent reports have suggested that the Glu298Asp polymorphism in exon 7 of the endothelial nitric oxide synthase gene is associated with coronary spasm and acute myocardial infarction.
|
12243851 |
2002 |
Coronary Artery Vasospasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently, endothelial nitric oxide synthase (eNOS) gene polymorphisms were reported to be associated with hypertension or coronary spasm.
|
11677358 |
2001 |
Coronary Artery Vasospasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic risk factors for coronary artery spasm: significance of endothelial nitric oxide synthase gene T-786-->C and missense Glu298Asp variants.
|
10979242 |
2000 |
Coronary Artery Vasospasm
|
0.400 |
Biomarker
|
disease |
CTD_human |
Taken together, these findings strongly suggest that the T-786-->C mutation in the eNOS gene reduces the endothelial NO synthesis and predisposes the patients with the mutation to coronary spasm.
|
10359729 |
1999 |
Coronary Artery Vasospasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Taken together, these findings strongly suggest that the T-786-->C mutation in the eNOS gene reduces the endothelial NO synthesis and predisposes the patients with the mutation to coronary spasm.
|
10359729 |
1999 |
Coronary Artery Vasospasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently, we reported that a missense Glu298Asp variant in exon 7 of the eNOS gene is a possible genetic factor involved in the pathogenesis of coronary spasm.
|
9626827 |
1998 |
Coronary Artery Vasospasm
|
0.400 |
Biomarker
|
disease |
CTD_human |
After initial screening in the entire 26 coding regions of the eNOS gene, we found a missense Glu298Asp variant in exon 7 in patients with coronary spasm.
|
9737779 |
1998 |
Coronary Artery Vasospasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently a point mutation of guanine to thymine at nucleotide position 1917 in the endothelial nitric oxide synthase (eNOS) gene has been reported to be associated with coronary artery spasm.
|
9740620 |
1998 |
Coronary Artery Vasospasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese.
|
9737779 |
1998 |