Heart failure
|
0.600 |
Therapeutic
|
disease |
RGD |
Increasing the expression of GTP cyclohydrolase 1, the rate-limiting enzyme in the de novo biosynthesis of tetrahydrobiopterin, exercise training couples endothelial nitric oxide synthase, reduces oxidative stress, and increases nitric oxide bioavailability and sensitivity in coronary arteries of heart failure rats.
|
29351461 |
2018 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Increasing the expression of GTP cyclohydrolase 1, the rate-limiting enzyme in the de novo biosynthesis of tetrahydrobiopterin, exercise training couples endothelial nitric oxide synthase, reduces oxidative stress, and increases nitric oxide bioavailability and sensitivity in coronary arteries of heart failure rats.
|
29351461 |
2018 |
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The mRNA expressions of Cav1.2, Nav1.5, Kir2.1, KvLQT1, phosphoinositide 3-kinase, AKT, and endothelial nitric oxide synthase in HF-RDN were significantly higher compared with HF.
|
29358197 |
2018 |
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Heart failure and endothelial nitric oxide synthase G894T gene polymorphism frequency variations within ancestries.
|
28554876 |
2018 |
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
NOS3 -786 C/T rs2070744 polymorphism in DCM may serve as a marker for more rapid progression of heart failure.
|
27448535 |
2016 |
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Endothelial nitric oxide synthase (eNOS) Glu298Asp single nucleotide polymorphism (SNP) genotype has been associated with a worse phenotype amongst patients with established heart failure and in patients with progression of their renal disease.
|
25612295 |
2015 |
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Homozygosity for the G allele of the eNOS G894T polymorphism was associated with worse survival in systolic HF patients, especially in those treated with nitrates.
|
25917853 |
2015 |
Heart failure
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Thus, increased VCAM-1 and PAI-1, and decreased eNOS phosphorylation through the TLR4/NFκB/p38 pathway, may be associated with atrial thrombogenesis in the heart failure mice model.
|
23754516 |
2014 |
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Expression of constitutive NOS isoforms in heart exhibits wide variability in HF patients, but this variability was not related to aetiology, disease severity, concomitant pathologies or drug regimes.
|
23770231 |
2013 |
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Previous studies have analyzed the role of the genetic polymorphism of endothelial nitric oxide synthase on heart failure prognosis.
|
23949326 |
2013 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our findings suggest the possible implication of NOS3 gene in the disease phenotype, wherein NOS3 may be synergistically functioning in DCM associated heart failure via the excessive production of NO in cardiomyocytes resulting in decreased myocardial contractility and systolic dysfunction, a common feature of DCM phenotype.
|
23923002 |
2013 |
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This prospective study was designed to analyze the impact of three eNOS polymorphisms (T-786C, VNTR4a/b and Glu298Asp) and their haplotypes on the susceptibility and clinical outcomes in HF outpatients with systolic dysfunction.
|
22290017 |
2012 |
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
After myocardial infarction, up-regulation of myocardial nNOS attenuates adverse remodeling and prevents arrhythmias whereas uncoupled eNOS activity in murine models of left ventricular pressure overload accelerates the progress towards heart failure.
|
21945464 |
2012 |
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
For NOS3 -922 A>G (rs1800779), a higher HR was found in minor allele carriers for heart failure (AA = 1.00, AG+GG = 1.10 (CI = 1.00-1.21), P = 0.046).
|
22470539 |
2012 |
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
After controlling for demographics, functional status, and treatment adherence, polymorphisms in ADRB1, ADRB2 and eNOS are associated with healthcare outcomes in heart failure patients.
|
22543981 |
2012 |
Heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure.
|
20304815 |
2010 |
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Endothelial nitric oxide synthase Glu298Asp gene polymorphism in a multi-ethnical population with heart failure and controls.
|
20079452 |
2010 |
Heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
Isoproterenol-induced heart failure in the rat is associated with nitric oxide-dependent functional alterations of cardiac function.
|
19168511 |
2009 |
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Endothelial nitric oxide synthase (NOS3) polymorphisms in African Americans with heart failure: results from the A-HeFT trial.
|
19327620 |
2009 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Despite the fact that women were older than men (72.3 vs. 69.5 years, p = 0.001) at recruitment, poor long-term survival was not sex-related, but instead predicted by age (p < 0.0001), cardiac failure (p = 0.004), smoking (p = 0.017), diabetes (p = 0.049), and variation in the eNOS gene locus (p = 0.033).
|
18648197 |
2008 |
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We conclude that heart failure down-regulates both eNOS activity and expression in cardiac tissue from patients with LVEF <35%.
|
15334196 |
2004 |