Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests a strong association of G894 T eNOS polymorphism with susceptibility to EH in Morocco.
|
30053839 |
2018 |
Essential Hypertension
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Collectively, these data indicate that HCMV may contribute to EH development in the Kazakh Chinese by increasing TNF-α and 8-OHDG levels, suppressing eNOS and renin, and manipulating <i>HSD3B2</i> and <i>ACE</i> methylation.
|
29752343 |
2018 |
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study aims to investigate the association between these three polymorphisms in the NOS3 gene and EH in Sudanese patients.
|
29132319 |
2017 |
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We examined whether the NOS3 tagSNPs rs3918226, rs3918188, and rs743506, and their haplotypes, affect the antihypertensive responses to enalapril in 101 patients with essential hypertension.
|
27060232 |
2016 |
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to assess the potential impact of obesity, and angiotensin-converting enzyme (ACE) I/D polymorphism and endothelial nitric oxide synthase gene (NOS3) 4a/4b, G894T and -T786C variants on the essential hypertension.
|
26579574 |
2015 |
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Abstract Background: The G894T (rs1799983) polymorphism in endothelial nitric oxide synthase (eNOS/NOS3) gene has been implicated in susceptibility to essential hypertension (EH) in some studies, but no clear consensus has been reached in the Chinese population.
|
24846690 |
2015 |
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The eNOS T allele is not more prevalent among hypertensive children than among healthy ones, but it is associated with early vascular damage in children with PH, independent of metabolic abnormalities.
|
26227630 |
2015 |
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Essential hypertension patients were genotyped for 11 polymorphisms of essential hypertension susceptibility genes including ADD1 (rs4961), GNB3 (rs5443, rs16932941), NOS3 (rs1799983, rs2070744), ACE (rs5186), AGTR1 (rs5186), AGT (rs699, rs4762), MR (rs5534), and TGFB1 (rs1800471).
|
26335431 |
2015 |
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that polymorphism of rs1800780 (A→G) in the eNOS gene may be one of the most important genetic factors associated with essential hypertension susceptibility, and those who have haplotype TGA may be at risk to develop essential hypertension.
|
24292621 |
2014 |
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of rs1799983 (G>T) and rs1800780 (A>G) of the eNOS gene associated with susceptibility to essential hypertension in the Chinese Hui ethnic population.
|
23613274 |
2013 |
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the eNOS polymorphism is one of the factors contributing to the predisposition for essential hypertension in the Han population in southwestern China.
|
21968727 |
2011 |
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Endothelial nitric oxide synthase gene polymorphisms and essential hypertension in Han Chinese.
|
20882485 |
2010 |
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The purpose of the present study was to determine whether three common variants in NOS3 (the eNOS gene) are associated with the risk of LVH [LV (left ventricular) hypertrophy] in patients with essential hypertension.
|
19132956 |
2009 |
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Here, we investigated the role of the -922A/G, -786T/C, 4b/4a, and 894G/T polymorphisms of the NOS3 and NO(x) levels in 800 consecutive unrelated subjects comprising 455 patients of essential hypertension and 345 controls.
|
18325347 |
2008 |
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our objective was to investigate the association of eNOS gene polymorphism with essential hypertension in a south Indian population.
|
18582449 |
2008 |
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Several reports suggested association between the T allele of the endothelial nitric oxide synthase gene polymorphism (eNOS) Glu298Asp (G --> T at nucleotide 894, exon 7) with essential hypertension (EHT).Findings, however are not uniform.
|
17935708 |
2008 |
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The present study suggested an association between a G894T polymorphism of eNOS gene and EH in Hani and Yi minority groups of China.
|
18164968 |
2008 |
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The results suggest that eNOS4 gene polymorphisms are unlikely to be the major genetic susceptibility factors for essential hypertension in the Xinjiang Kazakh population.
|
17492127 |
2007 |
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the present study in a population of Pakistani adult Pathans does not support the association of the eNOS gene G894T polymorphism to essential hypertension.
|
16765468 |
2007 |
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Endothelial nitric oxide synthase (eNOS) gene polymorphisms are associated with coronary artery disease, but their linkage with primary hypertension is controversial.
|
17024134 |
2006 |
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The study results suggest that the three eNOS gene polymorphisms are unlikely to be major genetic susceptibility factors for essential hypertension in the northern Han Chinese population.
|
16834924 |
2006 |
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms.
|
16024729 |
2005 |
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Premature death and age-related cardiac dysfunction in male eNOS-knockout mice.
|
15350840 |
2004 |
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Peroxisome proliferator-activated receptor-gamma2-Pro12Ala and endothelial nitric oxide synthase-4a/bgene polymorphisms are associated with essential hypertension.
|
12923396 |
2003 |
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Evidence for the involvement of eNOS single nucleotide polymorphisms in the development of essential hypertension is limited, though the eNOS Glu298Asp polymorphism appears to influence the blood pressure response to exercise.
|
12530931 |
2003 |