NOS3, nitric oxide synthase 3, 4846

N. diseases: 706; N. variants: 39
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension
0.600 GeneticVariation disease BEFREE Our study suggests a strong association of G894 T eNOS polymorphism with susceptibility to EH in Morocco. 30053839 2018
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension
0.600 AlteredExpression disease BEFREE Collectively, these data indicate that HCMV may contribute to EH development in the Kazakh Chinese by increasing TNF-α and 8-OHDG levels, suppressing eNOS and renin, and manipulating <i>HSD3B2</i> and <i>ACE</i> methylation. 29752343 2018
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension
0.600 GeneticVariation disease BEFREE This study aims to investigate the association between these three polymorphisms in the NOS3 gene and EH in Sudanese patients. 29132319 2017
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension
0.600 GeneticVariation disease BEFREE We examined whether the NOS3 tagSNPs rs3918226, rs3918188, and rs743506, and their haplotypes, affect the antihypertensive responses to enalapril in 101 patients with essential hypertension. 27060232 2016
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension
0.600 GeneticVariation disease BEFREE The aim of the present study was to assess the potential impact of obesity, and angiotensin-converting enzyme (ACE) I/D polymorphism and endothelial nitric oxide synthase gene (NOS3) 4a/4b, G894T and -T786C variants on the essential hypertension. 26579574 2015
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension
0.600 GeneticVariation disease BEFREE Abstract Background: The G894T (rs1799983) polymorphism in endothelial nitric oxide synthase (eNOS/NOS3) gene has been implicated in susceptibility to essential hypertension (EH) in some studies, but no clear consensus has been reached in the Chinese population. 24846690 2015
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension
0.600 GeneticVariation disease BEFREE The eNOS T allele is not more prevalent among hypertensive children than among healthy ones, but it is associated with early vascular damage in children with PH, independent of metabolic abnormalities. 26227630 2015
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension
0.600 GeneticVariation disease BEFREE Essential hypertension patients were genotyped for 11 polymorphisms of essential hypertension susceptibility genes including ADD1 (rs4961), GNB3 (rs5443, rs16932941), NOS3 (rs1799983, rs2070744), ACE (rs5186), AGTR1 (rs5186), AGT (rs699, rs4762), MR (rs5534), and TGFB1 (rs1800471). 26335431 2015
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension
0.600 GeneticVariation disease BEFREE These findings suggest that polymorphism of rs1800780 (A→G) in the eNOS gene may be one of the most important genetic factors associated with essential hypertension susceptibility, and those who have haplotype TGA may be at risk to develop essential hypertension. 24292621 2014
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension
0.600 GeneticVariation disease BEFREE Polymorphisms of rs1799983 (G>T) and rs1800780 (A>G) of the eNOS gene associated with susceptibility to essential hypertension in the Chinese Hui ethnic population. 23613274 2013
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension
0.600 GeneticVariation disease BEFREE These results suggest that the eNOS polymorphism is one of the factors contributing to the predisposition for essential hypertension in the Han population in southwestern China. 21968727 2011
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension
0.600 GeneticVariation disease BEFREE Endothelial nitric oxide synthase gene polymorphisms and essential hypertension in Han Chinese. 20882485 2010
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension
0.600 GeneticVariation disease BEFREE The purpose of the present study was to determine whether three common variants in NOS3 (the eNOS gene) are associated with the risk of LVH [LV (left ventricular) hypertrophy] in patients with essential hypertension. 19132956 2009
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension
0.600 GeneticVariation disease BEFREE Here, we investigated the role of the -922A/G, -786T/C, 4b/4a, and 894G/T polymorphisms of the NOS3 and NO(x) levels in 800 consecutive unrelated subjects comprising 455 patients of essential hypertension and 345 controls. 18325347 2008
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension
0.600 GeneticVariation disease BEFREE Our objective was to investigate the association of eNOS gene polymorphism with essential hypertension in a south Indian population. 18582449 2008
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension
0.600 GeneticVariation disease BEFREE Several reports suggested association between the T allele of the endothelial nitric oxide synthase gene polymorphism (eNOS) Glu298Asp (G --> T at nucleotide 894, exon 7) with essential hypertension (EHT).Findings, however are not uniform. 17935708 2008
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension
0.600 GeneticVariation disease BEFREE The present study suggested an association between a G894T polymorphism of eNOS gene and EH in Hani and Yi minority groups of China. 18164968 2008
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension
0.600 GeneticVariation disease BEFREE The results suggest that eNOS4 gene polymorphisms are unlikely to be the major genetic susceptibility factors for essential hypertension in the Xinjiang Kazakh population. 17492127 2007
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension
0.600 GeneticVariation disease BEFREE In conclusion, the present study in a population of Pakistani adult Pathans does not support the association of the eNOS gene G894T polymorphism to essential hypertension. 16765468 2007
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension
0.600 GeneticVariation disease BEFREE Endothelial nitric oxide synthase (eNOS) gene polymorphisms are associated with coronary artery disease, but their linkage with primary hypertension is controversial. 17024134 2006
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension
0.600 GeneticVariation disease BEFREE The study results suggest that the three eNOS gene polymorphisms are unlikely to be major genetic susceptibility factors for essential hypertension in the northern Han Chinese population. 16834924 2006
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension
0.600 Biomarker disease MGD Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms. 16024729 2005
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension
0.600 Biomarker disease MGD Premature death and age-related cardiac dysfunction in male eNOS-knockout mice. 15350840 2004
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension
0.600 GeneticVariation disease BEFREE Peroxisome proliferator-activated receptor-gamma2-Pro12Ala and endothelial nitric oxide synthase-4a/bgene polymorphisms are associated with essential hypertension. 12923396 2003
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension
0.600 GeneticVariation disease BEFREE Evidence for the involvement of eNOS single nucleotide polymorphisms in the development of essential hypertension is limited, though the eNOS Glu298Asp polymorphism appears to influence the blood pressure response to exercise. 12530931 2003