Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Several studies have focused on the impaired role of endothelial nitric oxide synthase (NOS3) gene polymorphism and its association to erectile dysfunction (ED).
|
30977424 |
2019 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We performed a meta-analysis of published studies investigating the association between ED and three eNOS polymorphisms, intron 4 VNTR, G894T and T786C in humans.
|
29654965 |
2018 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis showed that the two single nucleotide polymorphisms in eNOS gene, G894T and T-786C, are strongly associated with the risk of erectile dysfunction.
|
26908069 |
2018 |
Erectile dysfunction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of the expression of the P2Y1, P2Y2, P2Y4, and P2Y6 receptors that reduces the ratio of phosphorylated eNOS/eNOS and eNOS activity may be one of the important mechanisms of erectile dysfunction caused by low androgen status.
|
29596864 |
2018 |
Erectile dysfunction
|
0.600 |
Therapeutic
|
disease |
RGD |
TNF-α antagonism with etanercept enhances penile NOS expression, cavernosal reactivity, and testosterone levels in aged rats.
|
29260891 |
2018 |
Erectile dysfunction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Inflammatory and vascular parameters including myeloperoxidase (MPO), cyclooxygenase2 (COX2), endothelial nitric oxide synthase (eNOS), malondialdehyde (MDA), superoxide dismutase (SOD), reactive oxygen species (ROS), and cytokines in treated and untreated ED rats were measured.
|
30484894 |
2018 |
Erectile dysfunction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In contrast, chronic alcohol administration changed the ultrastructures of the CC and suppressed eNOS expression, thereby leading to erectile dysfunction.
|
28064474 |
2017 |
Erectile dysfunction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These findings support that UCMS decreases penile constitutive NOS expression via TNF-α, which may contribute to the development of ED.
|
27904147 |
2017 |
Erectile dysfunction
|
0.600 |
Biomarker
|
disease |
BEFREE |
The oxidative stress biochemical markers were attenuated, while eNOS and SOD<sub>EX</sub> mRNA expression were restored in atorvastatin and sildenafil groups, which were found to be involved in ED pathogenesis.
|
28295458 |
2017 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The distributions of alleles (G894T, P < .005; T-786C, P < .015), genotypes (G894T, P < 0.015; T-786C, P < .010), and haplotypes (G894T/T-786C, P < .015) of the NOS3 polymorphisms were significantly different between patients with ED and controls.
|
28268155 |
2017 |
Erectile dysfunction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Electromagnetic cylinder ESWT device resulted in increased VEGF, nNOS, and eNOS expression; reduced smooth muscle atrophy; and increased endothelial cell regeneration in a DM-associated ED model.
|
29164834 |
2017 |
Erectile dysfunction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The decrease in the expression of endothelial NOS and NOS activity in penile cavernous tissue caused by systemic inflammatory and oxidative stress status induced by exposure to PM<sub>2.5</sub> may be one of the important risk factors of erectile dysfunction.
|
27592525 |
2017 |
Erectile dysfunction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The diabetic control group showed higher cGMP production level transcription and protein levels of eNOS and DKK3 and lower production levels of AGEs and miR-328 than the diabetic ED and diabetic ED+NC groups.
|
28599252 |
2017 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, an association between eNOS G894T polymorphism and ED risk is uncertain and should be updated.
|
25726156 |
2015 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We performed a meta-analysis to estimate the association between eNOS polymorphisms and ED risk.
|
25940782 |
2015 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We studied 118 patients; 63 patients had ED secondary to radical prostatectomy (PED) and 55 had organic, clinical ED. eNOS genotypes for three eNOS polymorphisms (T(-786)C, rs2070744; a variable number of tandem repeats (VNTR) in intron 4; and rs1799983" genes_norm="4846">Glu298Asp, rs1799983) were determined, and eNOS haplotypes were estimated using PHASE 2.1.
|
22064666 |
2013 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The eNOS 894T allele carriers are at greater risk for both MtS and ED, suggesting that eNOS G894T gene polymorphism might play an implication as a common genetic susceptibility factor to develop both disorders.
|
22304542 |
2012 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Neither of the eNOS polymorphisms, G894T or T-786C, was significantly associated with sexual or erectile dysfunction.
|
21749219 |
2011 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To evaluate a potential association between the G894T polymorphism in the eNOS gene and ED complaints in a population-based sample in São Paulo, Brazil.
|
19968769 |
2010 |
Erectile dysfunction
|
0.600 |
Biomarker
|
disease |
RGD |
In addition, ED was associated with decreased eNOS protein expression at both ages.
|
20807325 |
2010 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Five genetic models and a generalized odds ratio (OR(G) ) were used to estimate the association between eNOS G894T and variable number of 27-bp tandem repeats in intron 4 (4 VNTR) and the risk of ED.
|
20722785 |
2010 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The CC genotype of T-786C polymorphism in the promoter of eNOS gene is associated with increased risk of ED in Turkish population.
|
19800665 |
2010 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to determine the relationship between erectile dysfunction (ED), coronary artery disease (CAD), and T(-786)C and intron 4 a/b endothelial nitric oxide synthase (eNOS) polymorphisms in 419 patients with suspected or known CAD referred for coronary angiography.
|
19466514 |
2009 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, there has been no report investigating the eNOS G894T genetic susceptibility factor for both ED and BPH/LUTS.
|
19515207 |
2009 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
eNOS gene intron 4 VNTR and exon 7-G894T polymorphisms in Turkish men with erectile dysfunction: a case control study.
|
19473288 |
2009 |