NOS3, nitric oxide synthase 3, 4846

N. diseases: 706; N. variants: 39
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction
0.600 GeneticVariation disease BEFREE Several studies have focused on the impaired role of endothelial nitric oxide synthase (NOS3) gene polymorphism and its association to erectile dysfunction (ED). 30977424 2019
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction
0.600 GeneticVariation disease BEFREE We performed a meta-analysis of published studies investigating the association between ED and three eNOS polymorphisms, intron 4 VNTR, G894T and T786C in humans. 29654965 2018
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction
0.600 GeneticVariation disease BEFREE Our meta-analysis showed that the two single nucleotide polymorphisms in eNOS gene, G894T and T-786C, are strongly associated with the risk of erectile dysfunction. 26908069 2018
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction
0.600 AlteredExpression disease BEFREE Downregulation of the expression of the P2Y1, P2Y2, P2Y4, and P2Y6 receptors that reduces the ratio of phosphorylated eNOS/eNOS and eNOS activity may be one of the important mechanisms of erectile dysfunction caused by low androgen status. 29596864 2018
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction
0.600 Therapeutic disease RGD TNF-α antagonism with etanercept enhances penile NOS expression, cavernosal reactivity, and testosterone levels in aged rats. 29260891 2018
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction
0.600 Biomarker disease BEFREE Inflammatory and vascular parameters including myeloperoxidase (MPO), cyclooxygenase2 (COX2), endothelial nitric oxide synthase (eNOS), malondialdehyde (MDA), superoxide dismutase (SOD), reactive oxygen species (ROS), and cytokines in treated and untreated ED rats were measured. 30484894 2018
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction
0.600 AlteredExpression disease BEFREE In contrast, chronic alcohol administration changed the ultrastructures of the CC and suppressed eNOS expression, thereby leading to erectile dysfunction. 28064474 2017
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction
0.600 AlteredExpression disease BEFREE These findings support that UCMS decreases penile constitutive NOS expression via TNF-α, which may contribute to the development of ED. 27904147 2017
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction
0.600 Biomarker disease BEFREE The oxidative stress biochemical markers were attenuated, while eNOS and SOD<sub>EX</sub> mRNA expression were restored in atorvastatin and sildenafil groups, which were found to be involved in ED pathogenesis. 28295458 2017
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction
0.600 GeneticVariation disease BEFREE The distributions of alleles (G894T, P < .005; T-786C, P < .015), genotypes (G894T, P < 0.015; T-786C, P < .010), and haplotypes (G894T/T-786C, P < .015) of the NOS3 polymorphisms were significantly different between patients with ED and controls. 28268155 2017
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction
0.600 AlteredExpression disease BEFREE Electromagnetic cylinder ESWT device resulted in increased VEGF, nNOS, and eNOS expression; reduced smooth muscle atrophy; and increased endothelial cell regeneration in a DM-associated ED model. 29164834 2017
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction
0.600 AlteredExpression disease BEFREE The decrease in the expression of endothelial NOS and NOS activity in penile cavernous tissue caused by systemic inflammatory and oxidative stress status induced by exposure to PM<sub>2.5</sub> may be one of the important risk factors of erectile dysfunction. 27592525 2017
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction
0.600 AlteredExpression disease BEFREE The diabetic control group showed higher cGMP production level transcription and protein levels of eNOS and DKK3 and lower production levels of AGEs and miR-328 than the diabetic ED and diabetic ED+NC groups. 28599252 2017
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction
0.600 GeneticVariation disease BEFREE However, an association between eNOS G894T polymorphism and ED risk is uncertain and should be updated. 25726156 2015
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction
0.600 GeneticVariation disease BEFREE We performed a meta-analysis to estimate the association between eNOS polymorphisms and ED risk. 25940782 2015
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction
0.600 GeneticVariation disease BEFREE We studied 118 patients; 63 patients had ED secondary to radical prostatectomy (PED) and 55 had organic, clinical ED. eNOS genotypes for three eNOS polymorphisms (T(-786)C, rs2070744; a variable number of tandem repeats (VNTR) in intron 4; and rs1799983" genes_norm="4846">Glu298Asp, rs1799983) were determined, and eNOS haplotypes were estimated using PHASE 2.1. 22064666 2013
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction
0.600 GeneticVariation disease BEFREE The eNOS 894T allele carriers are at greater risk for both MtS and ED, suggesting that eNOS G894T gene polymorphism might play an implication as a common genetic susceptibility factor to develop both disorders. 22304542 2012
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction
0.600 GeneticVariation disease BEFREE Neither of the eNOS polymorphisms, G894T or T-786C, was significantly associated with sexual or erectile dysfunction. 21749219 2011
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction
0.600 GeneticVariation disease BEFREE To evaluate a potential association between the G894T polymorphism in the eNOS gene and ED complaints in a population-based sample in São Paulo, Brazil. 19968769 2010
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction
0.600 Biomarker disease RGD In addition, ED was associated with decreased eNOS protein expression at both ages. 20807325 2010
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction
0.600 GeneticVariation disease BEFREE Five genetic models and a generalized odds ratio (OR(G) ) were used to estimate the association between eNOS G894T and variable number of 27-bp tandem repeats in intron 4 (4 VNTR) and the risk of ED. 20722785 2010
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction
0.600 GeneticVariation disease BEFREE The CC genotype of T-786C polymorphism in the promoter of eNOS gene is associated with increased risk of ED in Turkish population. 19800665 2010
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction
0.600 GeneticVariation disease BEFREE The purpose of this study was to determine the relationship between erectile dysfunction (ED), coronary artery disease (CAD), and T(-786)C and intron 4 a/b endothelial nitric oxide synthase (eNOS) polymorphisms in 419 patients with suspected or known CAD referred for coronary angiography. 19466514 2009
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction
0.600 GeneticVariation disease BEFREE However, there has been no report investigating the eNOS G894T genetic susceptibility factor for both ED and BPH/LUTS. 19515207 2009
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction
0.600 GeneticVariation disease BEFREE eNOS gene intron 4 VNTR and exon 7-G894T polymorphisms in Turkish men with erectile dysfunction: a case control study. 19473288 2009