NOS3, nitric oxide synthase 3, 4846

N. diseases: 706; N. variants: 39
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.600 Biomarker disease BEFREE We demonstrated previously that offspring born to pregnant mice lacking the endothelial nitric oxide synthase (eNOS+/-) gene have hypertension (HTN) as adults and, when fed a high-fat diet (HFD), develop a metabolic syndrome (MS) phenotype. 30521799 2019
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.600 GeneticVariation disease BEFREE The finding that metabolic syndrome is associated with worse cognition only in the presence of the eNOS-786C allele may clarify extant inconsistencies in the literature. 31421598 2019
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.600 Biomarker disease RGD Vascular endothelial function masks increased sympathetic vasopressor activity in rats with metabolic syndrome. 29127233 2018
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.600 Biomarker disease BEFREE Increased <i>O</i>-GlcNAcylation of Endothelial Nitric Oxide Synthase Compromises the Anti-contractile Properties of Perivascular Adipose Tissue in Metabolic Syndrome. 29681862 2018
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.600 GeneticVariation disease BEFREE NOS3 polymorphisms were genotyped in 70 SCH patients with MetS, 190 normal weight SCH patients, 155 MetS patients, and 100 healthy controls. 29907847 2018
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.600 AlteredExpression disease BEFREE Hormone replacement therapy increases eNOS activity and normalizes some characteristics of metabolic syndrome. 28196859 2017
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.600 AlteredExpression disease BEFREE We provide evidence that the activation of eNOS by HDL is decreased in MetS patients before the appearance of diabetes mellitus and that sphingosine-1-phosphate depletion of HDL is the main factor responsible for this defect. 28360087 2017
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.600 Therapeutic disease RGD Grape pomace reduced reperfusion arrhythmias in rats with a high-fat-fructose diet. 28967023 2017
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.600 GeneticVariation disease BEFREE However, there were significant decreases in intercellular adhesion molecules 1 (ICAM1), ezrin (EZR), mitogen-activated protein kinase kinase 2 (MAP2K2), and nitric oxide synthase 3 (NOS3) gene expressions in MetS patients. 26956845 2016
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.600 GeneticVariation disease BEFREE The eNOS 894T allele and interplay between the eNOS -786C allele and MetS may predispose Koreans to IS. 24976532 2014
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.600 GeneticVariation disease BEFREE This study focused on the peripheral vasculature as a cardiovascular phenotype and the influence of atypical antipsychotics, the aberrant metabolism of nitric oxide caused by endothelial nitric oxide synthetase (eNOS) genetic variants and metabolic syndrome in a cross-sectional sample of schizophrenia subjects. 24346810 2014
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.600 GeneticVariation disease BEFREE Our findings suggest that while eNOS haplotypes are not relevant, the CC genotype for the T(786)C polymorphism is associated with MetS in obese children and adolescents. 22983816 2013
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.600 GeneticVariation disease BEFREE We investigated the role of three NOS3 polymorphisms (T-786C, intron 4b/a, and G894T) in the risk of MetS using a hospital-based case-control study. 23324585 2013
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.600 GeneticVariation disease BEFREE The eNOS 894T allele carriers are at greater risk for both MtS and ED, suggesting that eNOS G894T gene polymorphism might play an implication as a common genetic susceptibility factor to develop both disorders. 22304542 2012
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.600 GeneticVariation disease BEFREE Anthropometric, clinical and biochemical parameters as well as genotyping for 894G>T, -786T>C variants of eNOS gene by PCR-RFLP and 4a/b by direct PCR were performed in 886 Saudi Arabians (477 MetS and 409 Non-MetS). 22240891 2012
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.600 GeneticVariation disease BEFREE NOS3 Glu298Asp polymorphism interacts with virgin olive oil phenols to determine the postprandial endothelial function in patients with the metabolic syndrome. 21816783 2011
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.600 Biomarker disease CTD_human Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice. 20876122 2010
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.600 Biomarker disease BEFREE The effect of dietary fat modification for 12 weeks on metabolic indices of the MetS was determined to understand potential NOS3 gene-nutrient interactions. 20409549 2010
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.600 Biomarker disease BEFREE Polymorphisms of genes for brain-derived neurotrophic factor, methylenetetrahydrofolate reductase, tyrosine hydroxylase, and endothelial nitric oxide synthase in depression and metabolic syndrome. 20163778 2010
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.600 GeneticVariation disease BEFREE Since patients with the metabolic syndrome are known to have endothelial dysfunction, we aimed to investigate if the significance of NOS3 polymorphisms may depend on the presence of the metabolic syndrome. 19407362 2009
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.600 GeneticVariation disease BEFREE Here, we performed a case-control study analyzing the association between 894G>T endothelial nitric oxide synthase gene polymorphism (NOS3) and MS in 616 subjects. 19169496 2008
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.600 GeneticVariation disease BEFREE This study shows that, in a Chinese population, eNOS G894T polymorphism is associated with an elevated C-reactive protein level and MS. 18640391 2008
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.600 GeneticVariation disease BEFREE Our results suggest that genetic variation at the eNOS locus is associated with features of metabolic syndrome, and might represent a new genetic susceptibility component for insulin resistance, hypertriglyceridemia, and low HDL-cholesterol concentrations. 17110473 2007
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.600 GeneticVariation disease BEFREE In this work we investigated the following: i) whether CAV1 is a quantitative trait locus of clustering of atherothrombotic traits associated with MS; ii) whether CVA1 is associated with hypertension or MS in hypertensive patients; and iii) whether genetic interaction between NOS3 and CAV1 is involved in the susceptibility or protection to hypertension associated with MS. To carry out the study, we genotyped 285 randomly selected individuals and 175 hypertensive patients, all of them < or = 60 years old, with two polymorphisms of the CAV1 gene: the 22285 C>T and the 22375-22375 del AC (GenBank AF125348), and the 1132T>C polymorphism of the NOS3 gene. 16601841 2006
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.600 Biomarker disease BEFREE Therefore red wine, since it enhances eNOS function, should be considered as a potential tool for the control of metabolic syndrome. 16170835 2006