NOTCH1, notch receptor 1, 4851

N. diseases: 693; N. variants: 64
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.360 Biomarker disease BEFREE NOTCH1 activates the Wnt/β-catenin signaling pathway in colon cancer. 28947978 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.360 AlteredExpression disease BEFREE Activation of Notch1 converted high-grade adenoma into low-grade adenoma in an Apcmin mouse colon cancer model and suppressed the expression of WNT target genes in human colorectal cancer cells through epigenetic modification recruiting histone methyltransferase SET domain bifurcated 1 (SETDB1). 22863622 2012
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.360 Biomarker disease BEFREE Conceivably, the modulation of Notch1-related signaling may be a promising therapy for human colon cancers. 20665495 2010
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.360 AlteredExpression disease BEFREE There is a well-documented association of matrix metalloproteinase-9 (MMP-9) and receptor Notch-1 overexpression in colon cancer. 20068187 2010
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.360 Biomarker disease CTD_human In summary, colon cancer cells may up-regulate Notch-1 as a protective mechanism in response to chemotherapy. 19147571 2009
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.360 AlteredExpression disease BEFREE We first show that the Notch-1 receptor, as well as its downstream target Hes-1, is up-regulated with colon cancer progression, similar to other genes involved in chemoresistance. 19147571 2009
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.360 AlteredExpression disease BEFREE To support this observation, colon cancer cell lines HT29 and SW620 were induced to differentiate in culture, and expression of Notch1 was investigated. 18777195 2009