Leukemia, T-Cell
|
0.400 |
Biomarker
|
disease |
BEFREE |
USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia.
|
30224337 |
2019 |
Leukemia, T-Cell
|
0.400 |
Biomarker
|
disease |
BEFREE |
We previously showed that the protein inhibitor of activated STAT-like coactivator Zmiz1 is a context-dependent cofactor of Notch1 in T-cell leukemia.
|
30076146 |
2018 |
Leukemia, T-Cell
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results suggest that targeting JAG1 can block Notch1 activation in HTLV-I-transformed cells and represents a new target for immunotherapy in ATL patients.
|
30231940 |
2018 |
Leukemia, T-Cell
|
0.400 |
Biomarker
|
disease |
BEFREE |
DEPTOR is a direct NOTCH1 target that promotes cell proliferation and survival in T-cell leukemia.
|
27593934 |
2017 |
Leukemia, T-Cell
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have previously described the presence of Notch1 activating mutations and constitutive Notch1 signaling in patients with acute ATL.
|
27247421 |
2016 |
Leukemia, T-Cell
|
0.400 |
Biomarker
|
disease |
CTD_human |
Developmental exposure to 2,3,7,8 tetrachlorodibenzo-p-dioxin attenuates later-life Notch1-mediated T cell development and leukemogenesis.
|
25585350 |
2015 |
Leukemia, T-Cell
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species.
|
23086478 |
2012 |
Leukemia, T-Cell
|
0.400 |
Biomarker
|
disease |
BEFREE |
Hes1 expression and CYLD repression are essential events downstream of Notch1 in T-cell leukemia.
|
21389783 |
2011 |
Leukemia, T-Cell
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data suggest that activated Notch may be important to ATL pathogenesis and reveal Notch1 as a target for therapeutic intervention in ATL patients.
|
20823234 |
2010 |
Leukemia, T-Cell
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The pathological implications of these findings are demonstrated by the regulation of IL-7Ralpha expression downstream of Notch1 in T cell leukemias.
|
19349467 |
2009 |
Leukemia, T-Cell
|
0.400 |
Biomarker
|
disease |
LHGDN |
In order to study the molecular mechanisms by which altered Notch signaling induces leukemia, a zebrafish model of human NOTCH1-induced T-cell leukemia was generated.
|
17252014 |
2007 |
Leukemia, T-Cell
|
0.400 |
Biomarker
|
disease |
BEFREE |
In order to study the molecular mechanisms by which altered Notch signaling induces leukemia, a zebrafish model of human NOTCH1-induced T-cell leukemia was generated.
|
17252014 |
2007 |
Leukemia, T-Cell
|
0.400 |
Biomarker
|
disease |
BEFREE |
The Notch1/c-Myc pathway in T cell leukemia.
|
17404512 |
2007 |
Leukemia, T-Cell
|
0.400 |
Biomarker
|
disease |
BEFREE |
Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.
|
17173050 |
2007 |
Leukemia, T-Cell
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.
|
17873882 |
2007 |
Leukemia, T-Cell
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although NOTCH1 mutation occurs infrequently in mature T-cell leukemia/lymphoma, NOTCH1 may be involved in leukemogenesis associated with various forms of T-cell leukemia/lymphoma rather than only with T-ALL.
|
17483057 |
2007 |
Leukemia, T-Cell
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.
|
17873882 |
2007 |
Leukemia, T-Cell
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Structurally distinct ligand-binding or ligand-independent Notch1 mutants are leukemogenic but affect thymocyte development, apoptosis, and metastasis differently.
|
16887975 |
2006 |
Leukemia, T-Cell
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Using gene expression profiling and chromatin immunoprecipitation, we identified c-myc as a novel, direct, and critical Notch1 target gene in T-cell leukemia. c-myc mRNA levels are increased in primary mouse T-cell tumors that harbor Notch1 mutations, and Notch1 inhibition decreases c-myc mRNA levels and inhibits leukemic cell growth.
|
16954387 |
2006 |