NOTCH1, notch receptor 1, 4851

N. diseases: 693; N. variants: 64
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Squamous cell carcinoma of esophagus
0.390 Biomarker disease BEFREE GASC1 promoted stemness in ESCC cells via NOTCH1 promoter demethylation. 31031809 2019
Squamous cell carcinoma of esophagus
0.390 AlteredExpression disease BEFREE Notch1 is downregulated in esophageal squamous cell carcinoma (p < 0.00001), Notch1 expression at high levels was detected in GC (p = 0.02) and CRC (p < 0.001), and no significant difference exists between PC and normal tissue (p = 0.76). 30043645 2018
Squamous cell carcinoma of esophagus
0.390 Biomarker disease BEFREE Taken together, the findings suggest that increased Notch 1 may contribute to the development and aggressiveness of esophageal SCC. 29137934 2018
Squamous cell carcinoma of esophagus
0.390 AlteredExpression disease BEFREE Moreover, Notch1 is activated in a small subset of SCC cells at the invasive tumor front and predicts for poor prognosis of esophageal SCC, shedding light upon the tumor promoting oncogenic aspect of Notch1 in SCC. 29170450 2017
Squamous cell carcinoma of esophagus
0.390 GeneticVariation disease BEFREE We identified statistically significant mutual exclusivity between mutations in NOTCH1 and PIK3CA in ESCC samples. 26528858 2016
Squamous cell carcinoma of esophagus
0.390 GeneticVariation disease BEFREE Although the cancer-associated genes TP53, PIK3CA, CDKN2A and their pathways showed no significant difference between stage I and stage III tumors, we identified and validated a prevalence of mutations in NOTCH1 and in the NOTCH pathway that indicate that they are involved in the preclinical and early stages of ESCC. 26759717 2016
Squamous cell carcinoma of esophagus
0.390 GeneticVariation disease BEFREE Another three genes, NFE2L2, PTCH1 and NOTCH1, are mutated in ESCC only. 24724606 2014
Squamous cell carcinoma of esophagus
0.390 Biomarker disease CTD_human Genetic landscape of esophageal squamous cell carcinoma. 25151357 2014
Squamous cell carcinoma of esophagus
0.390 AlteredExpression disease BEFREE We conclude that Notch1 expression is associated with cell aggressiveness and 5-FU drug resistance in human esophageal squamous cell carcinoma cell lines in vitro and is significantly associated with a poor survival in human esophageal squamous cell carcinomas. 23409141 2013
Squamous cell carcinoma of esophagus
0.390 AlteredExpression disease BEFREE Chi-square tests revealed that NF-κB and Notch1 expression in ESCC tissues were significant associated with lymph node metastasis, LVD, podoplanin, and VEGF-C expression. 21939555 2011