NOTCH1, notch receptor 1, 4851

N. diseases: 693; N. variants: 64
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker disease BEFREE Deubiquitylation and stabilization of Notch1 intracellular domain by ubiquitin-specific protease 8 enhance tumorigenesis in breast cancer. 31527799 2020
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker disease BEFREE Heme Oxygenase-1 Inhibits Tumor Metastasis Mediated by Notch1 Pathway in Murine Mammary Carcinoma. 30764900 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker disease BEFREE In vivo and in vitro experiments both showed that SNHG7 targeted miR-34a and promoted epithelial-to-mesenchymal transition (EMT) initiation and the Notch-1 pathway in breast cancer. 31132353 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression disease BEFREE Stable breast cancer (BC) cell lines with increased and decreased activity of Notch1 were generated using a transfection method. 31357442 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression disease BEFREE Firstly, the levels of Notch 1 were determined by western blot analysis in breast cancer cell lines, and the results revealed that the expression levels of Notch 1 were markedly higher in MDA‑MB‑231 and MCF‑7 cells, and lower in MCF‑10A cells, compared with human mammary epithelial cells. 29207146 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker disease BEFREE Quercetin‑3‑methyl ether suppresses human breast cancer stem cell formation by inhibiting the Notch1 and PI3K/Akt signaling pathways. 29956731 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker disease BEFREE We show that the miR-106b-25 cluster upregulates NOTCH1 in multiple breast cancer cell lines, representing both estrogen receptor (ER+) and triple negative breast cancer (TNBC) through direct repression of the E3 ubiquitin ligase, NEDD4L. 29662198 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression disease BEFREE Subsequently, Notch1 was identified as the functional target of miR‑449a, and the overexpression of circRNA-000911 in breast cancer elevated Notch1 expression. 29431182 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker disease BEFREE Inhibition of MEK1/2-ERK1/2 signaling in trastuzumab-resistant breast cancer cells mimics effects of Notch-1 knockdown on bulk cell proliferation and BCSC survival. 29743588 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker disease BEFREE Resistance to anti-HER2 therapy in HER2<sup>+</sup> breast cancer requires NOTCH1, and that combination of trastuzumab and a gamma secretase inhibitor (GSI) prevents tumor relapse in xenograft models.<b>Experimental Design:</b> The current study investigates mechanisms by which HER2 tyrosine kinase activity regulates NOTCH-dependent CSC survival and tumor initiation.<b>Results:</b> Lapatinib-mediated HER2 inhibition shifts the population of HER2<sup>+</sup> breast cancer cells from low membrane JAGGED1 expression to higher levels, independent of sensitivity to anti-HER2 treatment within the bulk cell population. 29895705 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression disease BEFREE Overexpression of Pofut1 and activated Notch1 may be associated with poor prognosis in breast cancer. 28709865 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker disease BEFREE OIP5 over-expression inhibited hsa-miR-139-5p expression, antagonized its functions and led to the de-repression of its endogenous target NOTCH1, which was a core oncogene in promoting breast cancer progression. 27916718 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker disease BEFREE These data suggest that the putative involvement of NOTCH1 as a tumor-promoting gene in breast cancer may depend on its lack of regulation in cancer, whereas its involvement in normal lumen formation requires activation of its expression, and subsequently, inhibition of its signaling. 28823832 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker disease BEFREE Notch1 and Notch4 have been reported as prognostic markers in human breast cancer. 28108315 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression disease BEFREE Furthermore, modulation of KRT19-mediated regulation of NUMB and NOTCH1 expression led to the repression of the cancer stem cell properties of breast cancer patient-derived CD133<sup>high</sup>/CXCR4<sup>high</sup>/ALDH1<sup>high</sup> cancer stem-like cells (CSLCs), which showed very low KRT19 and high NOTCH1 expression. 27345400 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression disease BEFREE Targeting aberrant expression of Notch-1 in ALDH<sup>+</sup> cancer stem cells in breast cancer. 27753148 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression disease BEFREE High expression of Notch-1 and its ligand Jagged-1 correlates with poor prognosis in breast cancer. 26945854 2016
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression disease BEFREE Our results showed that Notch1 messenger RNA (mRNA) high expression was correlated to worsen overall survival (OS) in PgR-negative BC patients. 26323259 2016
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 PosttranslationalModification disease BEFREE A study of the role of Notch1 and JAG1 gene methylation in development of breast cancer. 26971121 2016
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression disease BEFREE BRD4-selective knockdown suppressed Notch1 activity and impeded breast cancer migration and invasion. 27651315 2016
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker disease BEFREE To the best of our knowledge, this is the first study that introduces miR-9 and NOTCH1 correlation as an effective factor in breast cancer. 25963903 2015
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 PosttranslationalModification disease BEFREE We demonstrated that Notch1 induced phosphorylation of the signal transducer and activator of transcription 3 (STAT3) in breast cancer cells and increased the expression of p65 and interleukin (IL)-1β. 25544568 2015
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression disease BEFREE Notch-1 inhibits p53 activity in cervical and breast cancer cells. 26033683 2015
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker disease BEFREE Notch1 silencing reversed the spontaneous EMT process and inhibited the migration and invasion of breast cancer cells and the growth of xenograft breast cancers. 25645291 2015
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker disease BEFREE NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation. 25263445 2015