NPY, neuropeptide Y, 4852

N. diseases: 381; N. variants: 12
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.720 Biomarker disease BEFREE When taken together with observations of potential genetic linkage between the NPY system and the human alcohol abuse disorders, NPY represents a promising target for treating problematic alcohol and drug use, and in protecting individuals from relapse during abstinence. 29056151 2017
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.720 Biomarker disease PSYGENET Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. 20554694 2010
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.720 Biomarker disease CTD_human Search for biological correlates of depression and mechanisms of action of antidepressant treatment modalities. Do neuropeptides play a role? 17572454 2007
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.720 Biomarker disease RGD Effect of polymorphism on expression of the neuropeptide Y gene in inbred alcohol-preferring and -nonpreferring rats. 15749341 2005
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.720 Biomarker disease PSYGENET Therefore, decreased function of CREB in the central nucleus of the amygdala might regulate anxiety and alcohol intake via decreased expression of NPY, and might provide a common link between anxiety and alcohol abuse disorders. 12967770 2003
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.720 AlteredExpression disease BEFREE Therefore, decreased function of CREB in the central nucleus of the amygdala might regulate anxiety and alcohol intake via decreased expression of NPY, and might provide a common link between anxiety and alcohol abuse disorders. 12967770 2003
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 AlteredExpression disease BEFREE Clinical specimens from patients with prostate cancer with higher score of depression revealed higher CD68<sup>+</sup> TAM infiltration and stronger NPY and IL6 expression. 30504424 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE Neuropeptide Y is a peptide neuromodulator with protective roles including anxiolytic and antidepressant-like effects in animal models of depression and post-traumatic stress disorder. 31082535 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE All these results suggest that NPY and Y2R in the mPFC are involved in the pathophysiology of depression and NPY plays an antidepressant role in the mPFC mainly via Y2R, which suppresses the NLRP3 signaling pathway, in LPS-induced depression model rats. 31736656 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE All these results suggest that NPY and Y2R in the mPFC are involved in the pathophysiology of depression and NPY plays an antidepressant role in the mPFC mainly via Y2R, which suppresses the NLRP3 signaling pathway, in LPS-induced depression model rats. 31736656 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 AlteredExpression disease BEFREE Clinical specimens from patients with prostate cancer with higher score of depression revealed higher CD68<sup>+</sup> TAM infiltration and stronger NPY and IL6 expression. 30504424 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE Neuropeptide Y is a peptide neuromodulator with protective roles including anxiolytic and antidepressant-like effects in animal models of depression and post-traumatic stress disorder. 31082535 2019
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker disease BEFREE Numerous studies have indicated that the neuropeptides including ghrelin, neurotensin, pituitary adenylate cyclase-activating polypeptide (PACAP), neuropeptide Y, substance P and orexin are closely related to the pathophysiology of Alzheimer's disease. 30687008 2018
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker disease BEFREE Copper Binding Induces Nitration of NPY under Nitrative Stress: Complicating the Role of NPY in Alzheimer's Disease. 30079723 2018
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 AlteredExpression disease BEFREE Somatostatin (SOM) and Neuropeptide Y (NPY) are two neuropeptides which are expressed in GABAergic interneurons with different fates in AD the former only being markedly affected. 30327597 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE In addition to this decrease in depression-like behavior, brain-derived neurotrophic factor (BDNF) and neuropeptide Y (NPY) release increased in the hippocampus in response to MAI treatment, but estradiol levels did not recover. 29643431 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 AlteredExpression disease BEFREE At t<sub>1</sub>, increased mean levels of NPY in CSF significantly correlated with impaired performance in most ISR scores (ISR total p = .018, depression p = .035, anxiety p = .008, nutrition disorder p = .047, supplementary items p = .038) and in several psychological SF-36 items (vitality p = .019, general mental health p = .001, mental component summary p = .025). 30213237 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE In addition to this decrease in depression-like behavior, brain-derived neurotrophic factor (BDNF) and neuropeptide Y (NPY) release increased in the hippocampus in response to MAI treatment, but estradiol levels did not recover. 29643431 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 AlteredExpression disease BEFREE At t<sub>1</sub>, increased mean levels of NPY in CSF significantly correlated with impaired performance in most ISR scores (ISR total p = .018, depression p = .035, anxiety p = .008, nutrition disorder p = .047, supplementary items p = .038) and in several psychological SF-36 items (vitality p = .019, general mental health p = .001, mental component summary p = .025). 30213237 2018
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.600 Biomarker disease BEFREE Neuropeptide Y in Alcohol Addiction and Affective Disorders. 28824541 2017
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker disease BEFREE Recently, it has been shown that NPY protects cells against neurotoxic damage from β-amyloid peptides (Aβ) in Alzheimer's disease (AD). 28737807 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE Both NPY and CGRP were higher in PD patients with comorbid depression compared to MDD patients. 28659833 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE In this review, we present an overview of findings with regard to the NPY system in relation to anxiety and stress, acute as well as chronic; furthermore we discuss post-traumatic stress disorder and, in part depression. 28824541 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 AlteredExpression disease BEFREE Furthermore, the behavioral indicators of depression showed strong correlations with the serum levels and the hippocampal content of NPY. 28582442 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE In this review, we present an overview of findings with regard to the NPY system in relation to anxiety and stress, acute as well as chronic; furthermore we discuss post-traumatic stress disorder and, in part depression. 28824541 2017