Alcohol abuse
|
0.720 |
Biomarker
|
disease |
BEFREE |
When taken together with observations of potential genetic linkage between the NPY system and the human alcohol abuse disorders, NPY represents a promising target for treating problematic alcohol and drug use, and in protecting individuals from relapse during abstinence.
|
29056151 |
2017 |
Alcohol abuse
|
0.720 |
Biomarker
|
disease |
PSYGENET |
Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption.
|
20554694 |
2010 |
Alcohol abuse
|
0.720 |
Biomarker
|
disease |
CTD_human |
Search for biological correlates of depression and mechanisms of action of antidepressant treatment modalities. Do neuropeptides play a role?
|
17572454 |
2007 |
Alcohol abuse
|
0.720 |
Biomarker
|
disease |
RGD |
Effect of polymorphism on expression of the neuropeptide Y gene in inbred alcohol-preferring and -nonpreferring rats.
|
15749341 |
2005 |
Alcohol abuse
|
0.720 |
Biomarker
|
disease |
PSYGENET |
Therefore, decreased function of CREB in the central nucleus of the amygdala might regulate anxiety and alcohol intake via decreased expression of NPY, and might provide a common link between anxiety and alcohol abuse disorders.
|
12967770 |
2003 |
Alcohol abuse
|
0.720 |
AlteredExpression
|
disease |
BEFREE |
Therefore, decreased function of CREB in the central nucleus of the amygdala might regulate anxiety and alcohol intake via decreased expression of NPY, and might provide a common link between anxiety and alcohol abuse disorders.
|
12967770 |
2003 |
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Clinical specimens from patients with prostate cancer with higher score of depression revealed higher CD68<sup>+</sup> TAM infiltration and stronger NPY and IL6 expression.
|
30504424 |
2019 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Neuropeptide Y is a peptide neuromodulator with protective roles including anxiolytic and antidepressant-like effects in animal models of depression and post-traumatic stress disorder.
|
31082535 |
2019 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
All these results suggest that NPY and Y2R in the mPFC are involved in the pathophysiology of depression and NPY plays an antidepressant role in the mPFC mainly via Y2R, which suppresses the NLRP3 signaling pathway, in LPS-induced depression model rats.
|
31736656 |
2019 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
All these results suggest that NPY and Y2R in the mPFC are involved in the pathophysiology of depression and NPY plays an antidepressant role in the mPFC mainly via Y2R, which suppresses the NLRP3 signaling pathway, in LPS-induced depression model rats.
|
31736656 |
2019 |
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Clinical specimens from patients with prostate cancer with higher score of depression revealed higher CD68<sup>+</sup> TAM infiltration and stronger NPY and IL6 expression.
|
30504424 |
2019 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Neuropeptide Y is a peptide neuromodulator with protective roles including anxiolytic and antidepressant-like effects in animal models of depression and post-traumatic stress disorder.
|
31082535 |
2019 |
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Numerous studies have indicated that the neuropeptides including ghrelin, neurotensin, pituitary adenylate cyclase-activating polypeptide (PACAP), neuropeptide Y, substance P and orexin are closely related to the pathophysiology of Alzheimer's disease.
|
30687008 |
2018 |
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Copper Binding Induces Nitration of NPY under Nitrative Stress: Complicating the Role of NPY in Alzheimer's Disease.
|
30079723 |
2018 |
Alzheimer's Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Somatostatin (SOM) and Neuropeptide Y (NPY) are two neuropeptides which are expressed in GABAergic interneurons with different fates in AD the former only being markedly affected.
|
30327597 |
2018 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition to this decrease in depression-like behavior, brain-derived neurotrophic factor (BDNF) and neuropeptide Y (NPY) release increased in the hippocampus in response to MAI treatment, but estradiol levels did not recover.
|
29643431 |
2018 |
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
At t<sub>1</sub>, increased mean levels of NPY in CSF significantly correlated with impaired performance in most ISR scores (ISR total p = .018, depression p = .035, anxiety p = .008, nutrition disorder p = .047, supplementary items p = .038) and in several psychological SF-36 items (vitality p = .019, general mental health p = .001, mental component summary p = .025).
|
30213237 |
2018 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition to this decrease in depression-like behavior, brain-derived neurotrophic factor (BDNF) and neuropeptide Y (NPY) release increased in the hippocampus in response to MAI treatment, but estradiol levels did not recover.
|
29643431 |
2018 |
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
At t<sub>1</sub>, increased mean levels of NPY in CSF significantly correlated with impaired performance in most ISR scores (ISR total p = .018, depression p = .035, anxiety p = .008, nutrition disorder p = .047, supplementary items p = .038) and in several psychological SF-36 items (vitality p = .019, general mental health p = .001, mental component summary p = .025).
|
30213237 |
2018 |
Alcoholic Intoxication, Chronic
|
0.600 |
Biomarker
|
disease |
BEFREE |
Neuropeptide Y in Alcohol Addiction and Affective Disorders.
|
28824541 |
2017 |
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Recently, it has been shown that NPY protects cells against neurotoxic damage from β-amyloid peptides (Aβ) in Alzheimer's disease (AD).
|
28737807 |
2017 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Both NPY and CGRP were higher in PD patients with comorbid depression compared to MDD patients.
|
28659833 |
2017 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this review, we present an overview of findings with regard to the NPY system in relation to anxiety and stress, acute as well as chronic; furthermore we discuss post-traumatic stress disorder and, in part depression.
|
28824541 |
2017 |
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the behavioral indicators of depression showed strong correlations with the serum levels and the hippocampal content of NPY.
|
28582442 |
2017 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this review, we present an overview of findings with regard to the NPY system in relation to anxiety and stress, acute as well as chronic; furthermore we discuss post-traumatic stress disorder and, in part depression.
|
28824541 |
2017 |