NPY, neuropeptide Y, 4852

N. diseases: 381; N. variants: 12
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE NPY is involved in various neurological processes and neuropsychiatric disorders, including fear learning and anxiety disorders. 31708112 2020
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 AlteredExpression group BEFREE However, genetic mouse models in combination with novel neuron-controlling chemogenetic and optogenetic technologies have also uncovered additional functions for this Arc NPY population that go beyond the simple food intake stimulatory action and link these NPY neurons to the control of energy expenditure, thermogenesis, physical activity, food-seeking behavior, and anxiety. 31089694 2019
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE Two weeks after SPS, intranasal NPY at 300 µg/rat, but not 150 µg which was effective after one week, reversed SPS triggered elevated anxiety. 30878321 2019
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 AlteredExpression group BEFREE Decrease in NPY and PV expression in the hippocampus may explain the possible mechanism of hyperandrogenization induced anxiety. 31281833 2019
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE Although NPY has potent anxiolytic actions within the BLA, selective activation of BLA NPY Y<sub>2</sub> receptors (Y<sub>2</sub>Rs) acutely increases anxiety by an unknown mechanism. 30971438 2019
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE We analyzed the modulation of calcitonin gene-related peptide (CGRP; exerting anxiogenic effects in BNST), neuropeptide Y (NPY; exerting mainly anxiolytic effects), and microglia activation (neuroinflammation marker, thought to increase anxiety). 31114482 2019
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE Our findings support the conclusion that alterations in both hippocampal NPY and MC4R expression are involved in anxiety level changes in rats, while their quantitative relationship (NPY/MC4R ratio) is even more valuable in the estimation of anxiety regulation than individual alterations for both NPY and MC4R expression in the hippocampus. 30863280 2019
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE However, the role of GABA release from NPY+ interneurons in adolescent anxiety is unclear. 30024942 2018
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE Neuropeptide Y (NPY) receptors belong to the G-protein-coupled receptor superfamily and have important roles in food intake, anxiety and cancer biology <sup>1,2</sup> . 29670288 2018
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE In this review, we present an overview of findings with regard to the NPY system in relation to anxiety and stress, acute as well as chronic; furthermore we discuss post-traumatic stress disorder and, in part depression. 28824541 2017
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE Several reports have demonstrated that neuropeptide Y (NPY) is involved in food intake, epilepsy, circadian rhythms, drug seeking, pain and anxiety, and other physiological or pathological conditions. 29042065 2017
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE By demonstrating that NPY release modulates hippocampal synaptic plasticity and is impaired by predator scent stress, our results provide a novel mechanism by which stress-induced anxiety alters circuit function. 28053027 2017
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 AlteredExpression group BEFREE Increased melanocortin and decreased neuropeptide Y activity due to changes in histone acetylation in emotional brain circuitry may play a role in adolescent intermittent ethanol-induced anxiety phenotypes in adulthood. 28575455 2017
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE Substantial preclinical evidence supports the role of NPY in the modulation of stress response and in the regulation of anxiety in animal models. 27913193 2017
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE Galanin (GAL) and neuropeptide Y (NPY) are neuropeptides involved in behaviors associated with anxiety. 24841617 2015
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 AlteredExpression group BEFREE However, alterations in anxiety- and depression-regulating genes were present in the hypothalamus of BACHD mice including reduced mRNA expression of neuropeptide Y, tachykinin receptor 3 and vesicular monoamine transporter type 2 as well as increased expression of cocaine and amphetamine regulated transcript. 23697793 2013
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE NPY has recently gained much attention as an endogenous antiepileptic and antidepressant agent, as drugs with antiepileptic and/or mood-stabilizing properties may exert their action by increasing NPY concentrations, which in turn can reduce anxiety and depression levels, dampen seizures or increase seizure threshold. 23994577 2013
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE This differential genetic modulation of NPY stress response was suppressed in the SD group, who showed no stress-related increases in NPY and higher heart rate and greater anxiety, regardless of diplotype. 21917383 2012
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 GeneticVariation group BEFREE In conclusion, we provide further support for involvement of mainly GAD1, but also NPY in determining predisposition to anxiety disorders. 22328461 2012
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE CCK interacts with several anxiety-relevant neurotransmitters such as the serotonergic, GABA-ergic and noradrenergic system as well as with endocannabinoids, NPY and NPS. 22553078 2012
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE NPY has been attributed a central role in anxiety-like behavior, fear, nociception, and reward in rodents. 22938859 2012
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE Neuropeptide Y (NPY) has been found to play a role in the pathomechanism of both anxiety and depression. 19854625 2010
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 AlteredExpression group BEFREE A recent study found NPY expression to be inversely correlated with trait anxiety. 20037921 2010
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 AlteredExpression group BEFREE There is extensive evidence, from both clinical cases and rodent models, for reduced levels of the widely expressed neuropeptide Y (NPY) in anxiety and depressive disorders. 19264362 2009
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 AlteredExpression group BEFREE Here we show that the claims of Zhou et al. that neuropeptide Y (NPY) diplotype-predicted expression is correlated with trait anxiety (neuroticism) is not replicated in a data set consisting of phenotypically extreme individuals drawn from a large (n = 88,142) non-clinical population. 19340021 2009