NOTCH2, notch receptor 2, 4853

N. diseases: 384; N. variants: 30
Disease: Malignant neoplasm of urinary bladder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.340 Biomarker disease BEFREE The results of all mechanism experiments indicated that ARAP1-AS1 regulated miR-4735-3p/NOTCH2 axis in BCa by acting as a ceRNA. 30404578 2019
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.340 Biomarker disease BEFREE Studies indicating that NOTCH1 and NOTCH2 have opposite effects on the progression of bladder cancer could give rise to potential therapeutic approaches aimed at blocking or restoring the Notch pathway. 29643502 2018
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.340 Biomarker disease BEFREE We report a high rate of NOTCH2 copy number gain in bladder cancer. 26769750 2016
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.340 GeneticVariation disease BEFREE Here, we show that missense mutations in NOTCH1 and NOTCH2 found in human bladder cancers result in loss of function. 25574842 2015
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.340 CausalMutation disease CGI