Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The findings suggested that a common NPPA SNPs rs5063 was associated with serum ANP levels and ANP was prospectively associated with hypertension in the Chinese Han population.
|
31341238 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
The natriuretic peptide (NP) family (including ANP (atrial natriuretic peptide), BNP (brain natriuretic peptide), and CNP (C-type natriuretic peptide)), the NP receptors (NPRA, NPRB, and NPRC), and the related protease convertases (furin, corin, and PCSK6) constitute the NP system and represent relevant protective mechanisms toward the development of hypertension and associated conditions, such as atherosclerosis, stroke, myocardial infarction, heart failure, and renal injury.
|
30781751 |
2019 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
This study examined the SNPs AGT rs699 (Met235Thr), ADD1 rs4961 (rs4961" genes_norm="118">Gly460Trp), NPPA rs5063 (Val32Met), GPX1 rs1050450 (Pro198Leu), and AGTR1 rs5186 (A1166C) in relation to hypertension and salt sensitivity.
|
27480094 |
2017 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
In whites, the minor G allele of the atrial natriuretic peptide (ANP) genetic variant rs5068 is associated with higher circulating levels of ANP and B-type natriuretic peptide (BNP), lower risk of hypertension, higher high-density lipoprotein (HDL) cholesterol plasma levels, and lower prevalence of obesity and metabolic syndrome.
|
29253899 |
2017 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
As a risk factor, ANP gene polymorphisms may affect hypertension.
|
27413750 |
2016 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Variants in the human NPPA gene, encoding the ANP precursor, are associated with hypertension, stroke, coronary artery disease, heart failure (HF) and obesity.
|
26074089 |
2015 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Among others, the 2238T>C exon 3 variant has been associated with endothelial cell damage and dysfunction and with an increased risk of acute cardiovascular events, a frameshift mutation within exon 3 has been related to increased risk of atrial fibrillation, and ANP gene variants have been linked to increased risk of hypertension in different ethnic groups.
|
24611929 |
2014 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Quercetin inhibits left ventricular hypertrophy in spontaneously hypertensive rats and inhibits angiotensin II-induced H9C2 cells hypertrophy by enhancing PPAR-γ expression and suppressing AP-1 activity.
|
24039778 |
2013 |
Hypertensive disease
|
0.600 |
Therapeutic
|
group |
CTD_human |
Quercetin inhibits left ventricular hypertrophy in spontaneously hypertensive rats and inhibits angiotensin II-induced H9C2 cells hypertrophy by enhancing PPAR-γ expression and suppressing AP-1 activity.
|
24039778 |
2013 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Clinical trials have documented the benefits and risks of the use of synthetic ANP (Anaritide) and BNP (Nesiritide) for treating heart failure, renal failure, and hypertension.
|
20433683 |
2011 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Minor alleles of NPPA rs5068, rs5065 and rs198358 were associated with less history of hypertension; minor alleles of NPPA rs5068 and rs198358 was also associated with higher circulating natriuretic peptide levels (p=0.003 to p=0.04).
|
21276798 |
2011 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
In L-NAME treated rats, relative to Ad.Null or saline administration, Ad.CMV-hAM-4F2 (i) reduced augmented cardiomyocyte membrane protein oxidation and mRNA expression of pro-oxidant (p22phox) and anti-oxidant (SOD-3, GPx) genes; (ii) attenuated increased cardiomyocyte width and mRNA expression of hypertrophic (sk-alpha-actin) and cardio-endocrine (ANP) genes; (iii) did not attenuate hypertension.
|
20798523 |
2010 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Our studies suggested that ANP gene promoter polymorphism is associated with left ventricular hypertrophy in hypertension.
|
20137368 |
2010 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Two common single nucleotide polymorphisms (SNPs) in NPPA, rs5063 and rs5065, result in amino acid changes of the primary peptide and have been previously implicated in conditions associated with AF, including stroke and hypertension.
|
20543198 |
2010 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
RGD |
Ventricular function and natriuretic peptides in sequentially combined models of hypertension.
|
20139323 |
2010 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
NPPA gene polymorphisms may have a role in BP progression and incident hypertension.
|
19330901 |
2009 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
In mice, lack of corin prevents the conversion of pro-ANP to ANP and causes salt-sensitive hypertension.
|
18716601 |
2009 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
This report provides a comprehensive review of studies exploring NPPA polymorphisms in relation to hypertension and hypertension-related outcomes.
|
19146799 |
2009 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Common genetic variants at the NPPA-NPPB locus found to be associated with circulating natriuretic peptide concentrations contribute to interindividual variation in blood pressure and hypertension.
|
19219041 |
2009 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Common genetic variants at the NPPA-NPPB locus found to be associated with circulating natriuretic peptide concentrations contribute to interindividual variation in blood pressure and hypertension.
|
19219041 |
2009 |
Hypertensive disease
|
0.600 |
Therapeutic
|
group |
CTD_human |
Common genetic variants at the NPPA-NPPB locus found to be associated with circulating natriuretic peptide concentrations contribute to interindividual variation in blood pressure and hypertension.
|
19219041 |
2009 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
LHGDN |
In conclusion, our findings indicate that the -A2843G polymorphism in the ANP gene promoter might be a genetic risk factor for the development of LVH in patients with hypertension.
|
17672826 |
2008 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
In conclusion, our findings indicate that the -A2843G polymorphism in the ANP gene promoter might be a genetic risk factor for the development of LVH in patients with hypertension.
|
17672826 |
2008 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Pharmacogenetic association of the NPPA T2238C genetic variant with cardiovascular disease outcomes in patients with hypertension.
|
18212314 |
2008 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
LHGDN |
In this cohort, the ANP gene variant was associated with early blood pressure increase and predisposition to develop hypertension.
|
17525707 |
2007 |