Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.700 GeneticVariation group BEFREE We hereby investigated the association of common variants in ATP2B1 gene with LAS in asymptomatic Chinese hypertension patients. 29902063 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.700 GeneticVariation group BEFREE Recently STK39 rs3754777, ATP2B1 rs2681472 and rs17249754 have been associated with BP variation and hypertension. 31242870 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.700 GeneticVariation group GWASCAT Structural equation modeling for hypertension and type 2 diabetes based on multiple SNPs and multiple phenotypes. 31513605 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.700 GeneticVariation group GWASCAT Interethnic analyses of blood pressure loci in populations of East Asian and European descent. 30487518 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.700 Biomarker group BEFREE We reported previously that mice lacking ATP2B1 in vascular smooth muscle cells (VSMC ATP2B1 KO mice) exhibited high blood pressure and increased intracellular calcium concentration. 29046519 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.700 Biomarker group BEFREE We previously reported that systemic heterozygous ATP2B1-null (ATP2B1<sup>+/-</sup>) mice exhibited hypertension due to impaired endothelial nitric oxide synthase (eNOS) activity and decreased nitric oxide (NO) production. 29950683 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.700 GeneticVariation group BEFREE Our findings demonstrate that the hypertension-susceptibility variants in PLCE1 and ATP2B1 confer a protective effect on risk of developing anthracycline-related cardiotoxicity, and functional analyses suggest that these genes are influenced by exposure to anthracyclines. 28851949 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.700 Biomarker group BEFREE Genomewide association studies have linked ATP2B1, the gene for the plasma membrane calcium ATPase 1 (PMCA1), to blood pressure (BP) and hypertension. 28795531 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.700 GeneticVariation group BEFREE In conclusion, people with the major allele of ATP2B1 rs17249754 are susceptible to hypertension especially in low intake of Ca and high ratio of Na and K. 28934190 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.700 GeneticVariation group GWASCAT Interaction between Single Nucleotide Polymorphism and Urinary Sodium, Potassium, and Sodium-Potassium Ratio on the Risk of Hypertension in Korean Adults. 28273873 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.700 GeneticVariation group BEFREE Crossover analysis and stratified analysis indicated that BMI has a major effect on the development of hypertension, while ATP2B1 variants have a minor effect. 26933664 2016
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.700 GeneticVariation group BEFREE We confirmed that the ATP2B1 rs17249754 polymorphism had significant association with hypertension. 27149052 2016
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.700 GeneticVariation group GWASCAT Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension. 25249183 2015
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.700 GeneticVariation group BEFREE The present study confirmed the significant association of ATP2B1 rs17249754 with risk of hypertension among Chinese children, but failed to replicate the association of CSK rs1378942, MTHFR rs1801133, CYP17A1 rs1004467, STK39 rs3754777 and FGF5 rs16998073 with BP/risk of hypertension. 23759979 2014
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.700 GeneticVariation group BEFREE Five gene variants, rs11066280 (C12orf51), rs12229654 and rs3782889 (MYL2), rs2072134 (OAS3), rs2093395 (TREML2), and rs17249754 (ATP2B1), were found to be associated with hypertension mostly in men (P = 4.76 × 10(-14) to 4.46 × 10(-7) in the joint analysis); three SNPs (rs11066280, rs12229654, and rs3782889) remained significant after Bonferroni correction in an independent population. 24142389 2014
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.700 GeneticVariation group BEFREE We also observed a significant association of 4 SNPs and the GRS with hypertension (ATP2B1 rs17249754: P = 0.02; CSK rs1378942: P = 0.02; CYP17A1 rs1004467: P = 0.02; MTHFR rs1801133: P = 0.03; GRS: P = 0.0004). 23591986 2013
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.700 GeneticVariation group BEFREE Besides chr9p21 and COL4A1, known loci for CHD, these included SNPs having reported genome-wide association study association with hypertension (e.g., ATP2B1). 23727086 2013
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.700 GeneticVariation group BEFREE We validated the association of the ATP2B1 gene and susceptibility to hypertension, BP traits and cf-PWV in Chinese population. 23079715 2013
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.700 Biomarker group BEFREE Moreover, vascular smooth muscle cell ATP2B1 knockout mice exhibited high blood pressure in radio telemetry-based experiments. 23324996 2013
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.700 GeneticVariation group BEFREE Ex vivo mRNA expression analysis in umbilical artery smooth muscle cells indicated that reduced expression of this gene associated with the risk allele may be an underlying mechanism relating the ATP2B1 variant to hypertension. 22476231 2012
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.700 GeneticVariation group BEFREE In this study, a meta-analysis was performed to assess the association of the ATP2B1 rs2681472 polymorphism with hypertension risk in East Asians. 22229515 2012
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.700 GeneticVariation group BEFREE Polymorphisms on the COMT, ATP2B1, CYP11A1 and the CSK genes were confirmed to be associated with hypertension and blood pressure (BP). 21633377 2012
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.700 GeneticVariation group BEFREE Four loci-ATP2B1 (ATPase, Ca(++) transporting, plasma membrane 1), CSK (c-src tyrosine kinase), CYP17A1 (cytochrome P450 17A1) and PLEKHA7 (pleckstrin homology domain-containing family A member 7)-were associated with blood pressure and hypertension in the Korean population. 20414254 2010
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.700 GeneticVariation group BEFREE An additional hypertension case-control study confirmed that rs17249754 (in ATP2B1) increases hypertension risk in both the KARE and Health2 (meta-analysis, P-value=4.25 x 10(-9)) cohorts. 19960030 2010
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.700 Biomarker group BEFREE Significant associations were replicated for 7 loci-CASZ1, MTHFR, ITGA9, FGF5, CYP17A1-CNNM2, ATP2B1, and CSK-ULK3-with any or all of these 3 traits: systolic blood pressure (P=1.4x10(-14) to 0.05), diastolic blood pressure (P=1.9x10(-12) to 0.05), and hypertension (P=2.0x10(-14) to 0.006; odds ratio, 1.10 to 1.29). 20479155 2010