Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE The predictive value of NTRK1-pY674/pY675 together with wild-type TP53 and low PTPN6 expression could contribute to neuroblastoma patient prognosis. 30594749 2019
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE Neurotrophins (NTs) bind to two different classes of cell surface receptors, Trk receptor tyrosine kinases and p75NTR, both of which are expressed by neuroblastoma cells. 15015775 2004
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 GeneticVariation disease BEFREE Significantly lower levels of DNCL1 (PIN; P(c)(corrected) = 0.0054) and NTRK1 (TrkA; P(c) = 0.039) were found in NB tumours with unfavourable biology. 15737569 2005
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker disease BEFREE Immunohistochemical detection of high-affinity nerve growth factor receptor in neuroblastoma. 7576942 1995
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE Expression of NTRK1/TrkA affects immunogenicity of neuroblastoma cells. 23400852 2013
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker disease BEFREE The MP-N-TS cell line should be useful for clarifying the TRK-A and TRK-B signaling pathways responsible for the different prognoses in patients with NB. 11223544 2001
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker disease BEFREE Indeed, there is increasing evidence that TRK genes play an important role in the biology and clinical behavior of neuroblastomas, tumors of the peripheral nervous system. 9049830 1997
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE Expression of Trk receptors has been implicated in the pathogenesis and prognosis of embryonal tumors, including neuroblastoma, nephroblastoma, and medulloblastoma. 17973327 2008
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE Collectively, these results indicate that EZH2 plays important roles in preventing the differentiation of NB cells and also that EZH2-related NTRK1 transcriptional regulation may be the key pathway for NB cell differentiation. 29507419 2018
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker disease BEFREE The anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor that is involved in the pathogenesis of different types of human cancers, including neuroblastoma (NB). 21829174 2011
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker disease BEFREE Furthermore, MIZ-1 expression was positively correlated with the expression of favorable neuroblastoma genes (EFNB2, EFNB3, EPHB6, and NTRK1) in the human neuroblastoma xenograft therapeutic models. 17947461 2007
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE Downregulation of TrkA protein expression by miRNA‑92a promotes the proliferation and migration of human neuroblastoma cells. 24839961 2014
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE The aim of the present study was to investigate the effect of As<sub>2</sub>O<sub>3</sub> on Trk expression in NB cell lines and its potential therapeutic efficacy. 29898774 2018
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE Gene expression of TRK neurotrophin receptors in advanced neuroblastomas in Singapore--a pilot study. 21728718 2011
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 PosttranslationalModification disease BEFREE Northern blotting and nuclear run-on analyses demonstrated that transcription is a primary determinant of both cell-specific and variable expression of the TrkA gene in neuroblastoma cell lines that express it to different degrees. 9417044 1998
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE In addition, we tested two primary neuroblastomas that expressed TRK for responsiveness to nerve growth factor. 8441429 1993
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker disease BEFREE Because the Shc family proteins (ShcA, ShcB, and ShcC) are adaptors for various receptors, including Trk receptors, and are regulators of neuronal cell development, we speculated that they may play a role in neuroblastoma. 15867224 2005
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE We suggest that the transcriptional program of neuroblastoma cells is modulated by Trk-receptor expression and basal activation rather than by ligand-induced activation. 15637590 2005
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker disease BEFREE The treatment of NB cells with metformin or MIBG resulted in an increased expression of genes encoding biomarkers for favorable outcome in NB [(ephrin (EFN)B2, EFNB3, EPH receptor B6 (EPHB6), neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), CD44 and Myc-interacting zinc finger protein (MIZ-1)] and tumor suppressor genes [(early growth response 1 (EGR1), EPH receptor A2 (EPHA2), growth arrest and DNA-damage-inducible, beta (GADD45B), neuregulin 1 (NRG1), TP53 apoptosis effector (PERP) and sel-1 suppressor of lin-12-like (C. elegans) (SEL1L)]. 24190252 2014
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE In particular with the high-risk factors such as age of patient >1 year, MYCN amplification and low TRKA expression, the decreased expression of KLF4 was significantly associated with an unfavorable NB outcome. 23045286 2013
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE Here, we used the SH-SY5Y human neuroblastoma cell line ectopically expressing either TrkA or TrkB as a model system to analyze the impact of Trk receptor expression on NHEJ-mediated DSB repair. 18678285 2008
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE Of the 80 neuroblastomas, 65 (81%) expressed gp140TRK-A RNA. 8433391 1993
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker disease BEFREE We analyzed the expression of the following genes in 814 NBs using quantitative real-time reverse transcriptase polymerase chain reaction (RT-PCR): NTRK1, NTRK2, NTRK3, P75/NGFR, nerve growth factor (NGF), BDNF, IGFR1, and EGFR. 21990266 2012
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE Correlation of MYCN amplification, Trk-A and CD44 expression with clinical stage in 250 patients with neuroblastoma. 9516861 1997
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE In neuroblastoma (NB), expression of the TrkA receptor is correlated with good prognosis while N-myc amplification is correlated with poor prognosis. 14691455 2004