|
Neuroblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Significantly lower levels of DNCL1 (PIN; P(c)(corrected) = 0.0054) and NTRK1 (TrkA; P(c) = 0.039) were found in NB tumours with unfavourable biology.
|
15737569 |
2005 |
|
Neuroblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Moreover, pathogenic <i>KIF1B</i>β mutations identified in neuroblastoma impair TRKA transport.
|
28637693 |
2017 |
|
Neuroblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We report the first evidence of TrkA polymorphism and point mutations in neuroblastoma.
|
10200344 |
1999 |
|
Neuroblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
NTRK1 c.1810C>T polymorphism appears to be a new independent prognostic factor of poor outcome in neuroblastoma, especially in children under 18 months of age with no MYCN amplification.
|
20003389 |
2009 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Immunohistochemical detection of high-affinity nerve growth factor receptor in neuroblastoma.
|
7576942 |
1995 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The MP-N-TS cell line should be useful for clarifying the TRK-A and TRK-B signaling pathways responsible for the different prognoses in patients with NB.
|
11223544 |
2001 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Indeed, there is increasing evidence that TRK genes play an important role in the biology and clinical behavior of neuroblastomas, tumors of the peripheral nervous system.
|
9049830 |
1997 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor that is involved in the pathogenesis of different types of human cancers, including neuroblastoma (NB).
|
21829174 |
2011 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, MIZ-1 expression was positively correlated with the expression of favorable neuroblastoma genes (EFNB2, EFNB3, EPHB6, and NTRK1) in the human neuroblastoma xenograft therapeutic models.
|
17947461 |
2007 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Because the Shc family proteins (ShcA, ShcB, and ShcC) are adaptors for various receptors, including Trk receptors, and are regulators of neuronal cell development, we speculated that they may play a role in neuroblastoma.
|
15867224 |
2005 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The treatment of NB cells with metformin or MIBG resulted in an increased expression of genes encoding biomarkers for favorable outcome in NB [(ephrin (EFN)B2, EFNB3, EPH receptor B6 (EPHB6), neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), CD44 and Myc-interacting zinc finger protein (MIZ-1)] and tumor suppressor genes [(early growth response 1 (EGR1), EPH receptor A2 (EPHA2), growth arrest and DNA-damage-inducible, beta (GADD45B), neuregulin 1 (NRG1), TP53 apoptosis effector (PERP) and sel-1 suppressor of lin-12-like (C. elegans) (SEL1L)].
|
24190252 |
2014 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We analyzed the expression of the following genes in 814 NBs using quantitative real-time reverse transcriptase polymerase chain reaction (RT-PCR): NTRK1, NTRK2, NTRK3, P75/NGFR, nerve growth factor (NGF), BDNF, IGFR1, and EGFR.
|
21990266 |
2012 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recently, we highlighted that the ganglioside GM1 promotes neuroblastoma cells differentiation by activating the TrkA receptor through the formation of a TrkA-GM1 oligosaccharide complex at the cell surface.
|
30776097 |
2019 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Identification of a novel tyrosine kinase receptor-like molecule in neuroblastomas.
|
1281989 |
1992 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The over-expressions of brain-derived neurotrophic factor (BDNF) and its tyrosine kinase receptor TrkB have been reported to induce chemo-resistance in neuroblastoma (NB) cells.
|
29959561 |
2018 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, the restoration of the NGF-induced differentiation pathway by exogenous TRK-A presents a system of NGF-responsive human cultured cells and focuses attention on the trk-A protein and its function or malfunction in neuroblastoma.
|
7669728 |
1995 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Prognostic value of TrkA protein detection by monoclonal antibody 5C3 in neuroblastoma.
|
9816308 |
1996 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Expression of the high-affinity nerve growth factor (NGF) TrkA receptor in NB is correlated with good prognosis, while MYCN amplification is associated with advanced stages of disease.
|
16989911 |
2006 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
By directly connecting MYCN to the repression of TRKA and p75NTR, our findings establish a key pathway of clinical pathogenicity and aggressiveness in neuroblastoma.
|
21123453 |
2011 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expression of mRNA for the trk protooncogene, encoding a tyrosine kinase receptor essential for functional NGF signal transduction, and mRNA for the low affinity NGF receptor (LNGFR) was examined in 45 neuroblastomas and 3 benign ganglioneuromas using Northern blot analysis.
|
8481906 |
1993 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Entrectinib's activity against both ALK and TRK proteins suggests a possible role in NB treatment, and it is currently under investigation in both pediatric and adult oncology patients.
|
30425456 |
2018 |
|
Neuroblastoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Northern blotting and nuclear run-on analyses demonstrated that transcription is a primary determinant of both cell-specific and variable expression of the TrkA gene in neuroblastoma cell lines that express it to different degrees.
|
9417044 |
1998 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The predictive value of NTRK1-pY674/pY675 together with wild-type TP53 and low PTPN6 expression could contribute to neuroblastoma patient prognosis.
|
30594749 |
2019 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Neurotrophins (NTs) bind to two different classes of cell surface receptors, Trk receptor tyrosine kinases and p75NTR, both of which are expressed by neuroblastoma cells.
|
15015775 |
2004 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of NTRK1/TrkA affects immunogenicity of neuroblastoma cells.
|
23400852 |
2013 |