Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker disease BEFREE Identification of a novel tyrosine kinase receptor-like molecule in neuroblastomas. 1281989 1992
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker disease BEFREE Immunohistochemical detection of high-affinity nerve growth factor receptor in neuroblastoma. 7576942 1995
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker disease BEFREE Thus, the restoration of the NGF-induced differentiation pathway by exogenous TRK-A presents a system of NGF-responsive human cultured cells and focuses attention on the trk-A protein and its function or malfunction in neuroblastoma. 7669728 1995
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE A neuroblastoma is a common pediatric tumor derived from the neural crest, and the majority of favorable neuroblastomas express a high level of TRK-A mRNA. 8264643 1994
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE Of the 80 neuroblastomas, 65 (81%) expressed gp140TRK-A RNA. 8433391 1993
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE In addition, we tested two primary neuroblastomas that expressed TRK for responsiveness to nerve growth factor. 8441429 1993
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker disease BEFREE Expression of mRNA for the trk protooncogene, encoding a tyrosine kinase receptor essential for functional NGF signal transduction, and mRNA for the low affinity NGF receptor (LNGFR) was examined in 45 neuroblastomas and 3 benign ganglioneuromas using Northern blot analysis. 8481906 1993
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE trk A gene expression in neuroblastoma. The clinical significance of an immunohistochemical study. 8625212 1995
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker disease BEFREE Indeed, there is increasing evidence that TRK genes play an important role in the biology and clinical behavior of neuroblastomas, tumors of the peripheral nervous system. 9049830 1997
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE A total of 108 tumours were classified as neuroblastoma or ganglioneuroblastoma; 74 expressed TRKA protein, which strongly correlated with low stage, absence of N-MYC amplification, age (<1 year), CD44 expression and favourable clinical outcome. 9099963 1997
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 PosttranslationalModification disease BEFREE Northern blotting and nuclear run-on analyses demonstrated that transcription is a primary determinant of both cell-specific and variable expression of the TrkA gene in neuroblastoma cell lines that express it to different degrees. 9417044 1998
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE Correlation of MYCN amplification, Trk-A and CD44 expression with clinical stage in 250 patients with neuroblastoma. 9516861 1997
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE One hundred six NBs detected clinically (clinical NBs) were classified according to immunohistochemical expression of the Ha-ras and trk A genes. 9781958 1998
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker disease BEFREE Prognostic value of TrkA protein detection by monoclonal antibody 5C3 in neuroblastoma. 9816308 1996
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 GeneticVariation disease BEFREE We report the first evidence of TrkA polymorphism and point mutations in neuroblastoma. 10200344 1999
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE Expression level of trkA tyrosine kinase receptor for nerve growth factor is a major prognostic determinant of neuroblastoma, suggesting that defective trkA-mediated signaling is responsible for the tumorigenesis of this childhood malignancy. 10462038 1999
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker disease BEFREE The MP-N-TS cell line should be useful for clarifying the TRK-A and TRK-B signaling pathways responsible for the different prognoses in patients with NB. 11223544 2001
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE In neuroblastoma (NB), expression of the TrkA receptor is correlated with good prognosis while N-myc amplification is correlated with poor prognosis. 14691455 2004
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease LHGDN In neuroblastoma (NB), expression of the TrkA receptor is correlated with good prognosis while N-myc amplification is correlated with poor prognosis. 14691455 2004
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE Neurotrophins (NTs) bind to two different classes of cell surface receptors, Trk receptor tyrosine kinases and p75NTR, both of which are expressed by neuroblastoma cells. 15015775 2004
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE We suggest that the transcriptional program of neuroblastoma cells is modulated by Trk-receptor expression and basal activation rather than by ligand-induced activation. 15637590 2005
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 GeneticVariation disease BEFREE Significantly lower levels of DNCL1 (PIN; P(c)(corrected) = 0.0054) and NTRK1 (TrkA; P(c) = 0.039) were found in NB tumours with unfavourable biology. 15737569 2005
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker disease BEFREE Because the Shc family proteins (ShcA, ShcB, and ShcC) are adaptors for various receptors, including Trk receptors, and are regulators of neuronal cell development, we speculated that they may play a role in neuroblastoma. 15867224 2005
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression disease BEFREE Because another marker of poor prognosis in neuroblastoma tumors is high expression of brain-derived neurotrophic factor (BDNF) and its tyrosine kinase receptor, TrkB, we sought to evaluate the involvement of BDNF and TrkB in the regulation of VEGF expression. 16618748 2006
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker disease CTD_human Expression of the high-affinity nerve growth factor (NGF) TrkA receptor in NB is correlated with good prognosis, while MYCN amplification is associated with advanced stages of disease. 16989911 2006