Neuroblastoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Expression of the high-affinity nerve growth factor (NGF) TrkA receptor in NB is correlated with good prognosis, while MYCN amplification is associated with advanced stages of disease.
|
16989911 |
2006 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Because another marker of poor prognosis in neuroblastoma tumors is high expression of brain-derived neurotrophic factor (BDNF) and its tyrosine kinase receptor, TrkB, we sought to evaluate the involvement of BDNF and TrkB in the regulation of VEGF expression.
|
16618748 |
2006 |
Neuroblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Significantly lower levels of DNCL1 (PIN; P(c)(corrected) = 0.0054) and NTRK1 (TrkA; P(c) = 0.039) were found in NB tumours with unfavourable biology.
|
15737569 |
2005 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Because the Shc family proteins (ShcA, ShcB, and ShcC) are adaptors for various receptors, including Trk receptors, and are regulators of neuronal cell development, we speculated that they may play a role in neuroblastoma.
|
15867224 |
2005 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We suggest that the transcriptional program of neuroblastoma cells is modulated by Trk-receptor expression and basal activation rather than by ligand-induced activation.
|
15637590 |
2005 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Neurotrophins (NTs) bind to two different classes of cell surface receptors, Trk receptor tyrosine kinases and p75NTR, both of which are expressed by neuroblastoma cells.
|
15015775 |
2004 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In neuroblastoma (NB), expression of the TrkA receptor is correlated with good prognosis while N-myc amplification is correlated with poor prognosis.
|
14691455 |
2004 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
In neuroblastoma (NB), expression of the TrkA receptor is correlated with good prognosis while N-myc amplification is correlated with poor prognosis.
|
14691455 |
2004 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The MP-N-TS cell line should be useful for clarifying the TRK-A and TRK-B signaling pathways responsible for the different prognoses in patients with NB.
|
11223544 |
2001 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression level of trkA tyrosine kinase receptor for nerve growth factor is a major prognostic determinant of neuroblastoma, suggesting that defective trkA-mediated signaling is responsible for the tumorigenesis of this childhood malignancy.
|
10462038 |
1999 |
Neuroblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We report the first evidence of TrkA polymorphism and point mutations in neuroblastoma.
|
10200344 |
1999 |
Neuroblastoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Northern blotting and nuclear run-on analyses demonstrated that transcription is a primary determinant of both cell-specific and variable expression of the TrkA gene in neuroblastoma cell lines that express it to different degrees.
|
9417044 |
1998 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
One hundred six NBs detected clinically (clinical NBs) were classified according to immunohistochemical expression of the Ha-ras and trk A genes.
|
9781958 |
1998 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Indeed, there is increasing evidence that TRK genes play an important role in the biology and clinical behavior of neuroblastomas, tumors of the peripheral nervous system.
|
9049830 |
1997 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Correlation of MYCN amplification, Trk-A and CD44 expression with clinical stage in 250 patients with neuroblastoma.
|
9516861 |
1997 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A total of 108 tumours were classified as neuroblastoma or ganglioneuroblastoma; 74 expressed TRKA protein, which strongly correlated with low stage, absence of N-MYC amplification, age (<1 year), CD44 expression and favourable clinical outcome.
|
9099963 |
1997 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Prognostic value of TrkA protein detection by monoclonal antibody 5C3 in neuroblastoma.
|
9816308 |
1996 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Immunohistochemical detection of high-affinity nerve growth factor receptor in neuroblastoma.
|
7576942 |
1995 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, the restoration of the NGF-induced differentiation pathway by exogenous TRK-A presents a system of NGF-responsive human cultured cells and focuses attention on the trk-A protein and its function or malfunction in neuroblastoma.
|
7669728 |
1995 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
trk A gene expression in neuroblastoma. The clinical significance of an immunohistochemical study.
|
8625212 |
1995 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A neuroblastoma is a common pediatric tumor derived from the neural crest, and the majority of favorable neuroblastomas express a high level of TRK-A mRNA.
|
8264643 |
1994 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, we tested two primary neuroblastomas that expressed TRK for responsiveness to nerve growth factor.
|
8441429 |
1993 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Of the 80 neuroblastomas, 65 (81%) expressed gp140TRK-A RNA.
|
8433391 |
1993 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expression of mRNA for the trk protooncogene, encoding a tyrosine kinase receptor essential for functional NGF signal transduction, and mRNA for the low affinity NGF receptor (LNGFR) was examined in 45 neuroblastomas and 3 benign ganglioneuromas using Northern blot analysis.
|
8481906 |
1993 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Identification of a novel tyrosine kinase receptor-like molecule in neuroblastomas.
|
1281989 |
1992 |