Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression group BEFREE Downregulation of TrkA protein expression by miRNA‑92a promotes the proliferation and migration of human neuroblastoma cells. 24839961 2015
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression group BEFREE Expression of NTRK1/TrkA affects immunogenicity of neuroblastoma cells. 23400852 2013
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression group BEFREE In particular with the high-risk factors such as age of patient >1 year, MYCN amplification and low TRKA expression, the decreased expression of KLF4 was significantly associated with an unfavorable NB outcome. 23045286 2013
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression group BEFREE Exon-level expression analyses identify MYCN and NTRK1 as major determinants of alternative exon usage and robustly predict primary neuroblastoma outcome. 23047593 2012
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker group BEFREE The anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor that is involved in the pathogenesis of different types of human cancers, including neuroblastoma (NB). 21829174 2012
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression group BEFREE Gene expression of TRK neurotrophin receptors in advanced neuroblastomas in Singapore--a pilot study. 21728718 2012
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression group BEFREE High expression of NTRK1 is strongly associated with favorable risk factors and outcome in a large, representative population of NB patients. 21990266 2012
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker group BEFREE By directly connecting MYCN to the repression of TRKA and p75NTR, our findings establish a key pathway of clinical pathogenicity and aggressiveness in neuroblastoma. 21123453 2011
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 GeneticVariation group BEFREE c.1810C>T polymorphism of NTRK1 gene is associated with reduced survival in neuroblastoma patients. 20003389 2010
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression group BEFREE Trk-A, p75NRT, and GRP78 overexpression are favorable prognostic factors in pediatric neuroblastoma, whereas Trk-B is associated with a poorer prognosis in these tumors. 19386345 2009
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression group BEFREE Expression of Trk receptors is an important prognostic factor in neuroblastoma (NB) and other cancers. 19363525 2009
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression group BEFREE Here, we used the SH-SY5Y human neuroblastoma cell line ectopically expressing either TrkA or TrkB as a model system to analyze the impact of Trk receptor expression on NHEJ-mediated DSB repair. 18678285 2008
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression group BEFREE The expression of KIT, PDGFRbeta, and FLT3 mRNA was associated with NB in patients under 1 year (P < 0.02) and TRKA expression (P < 0.001). 17941064 2008
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression group BEFREE Expression of Trk receptors has been implicated in the pathogenesis and prognosis of embryonal tumors, including neuroblastoma, nephroblastoma, and medulloblastoma. 17973327 2008
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker group CTD_human Expression of the high-affinity nerve growth factor (NGF) TrkA receptor in NB is correlated with good prognosis, while MYCN amplification is associated with advanced stages of disease. 16989911 2007
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker group BEFREE Furthermore, MIZ-1 expression was positively correlated with the expression of favorable neuroblastoma genes (EFNB2, EFNB3, EPHB6, and NTRK1) in the human neuroblastoma xenograft therapeutic models. 17947461 2007
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression group BEFREE Because another marker of poor prognosis in neuroblastoma tumors is high expression of brain-derived neurotrophic factor (BDNF) and its tyrosine kinase receptor, TrkB, we sought to evaluate the involvement of BDNF and TrkB in the regulation of VEGF expression. 16618748 2006
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker group BEFREE Because the Shc family proteins (ShcA, ShcB, and ShcC) are adaptors for various receptors, including Trk receptors, and are regulators of neuronal cell development, we speculated that they may play a role in neuroblastoma. 15867224 2005
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression group BEFREE We suggest that the transcriptional program of neuroblastoma cells is modulated by Trk-receptor expression and basal activation rather than by ligand-induced activation. 15637590 2005
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 GeneticVariation group BEFREE Significantly lower levels of DNCL1 (PIN; P(c)(corrected) = 0.0054) and NTRK1 (TrkA; P(c) = 0.039) were found in NB tumours with unfavourable biology. 15737569 2005
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression group LHGDN Nerve growth factor decreases N-myc levels in TRKA-infected neuroblastoma cells and decreases cell proliferation via a MAPK path. 14691455 2004
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression group BEFREE Neurotrophin effects on neuroblastoma cells: correlation with trk and p75NTR expression and influence of Trk receptor bodies. 15015775 2004
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression group BEFREE In neuroblastoma (NB), expression of the TrkA receptor is correlated with good prognosis while N-myc amplification is correlated with poor prognosis. 14691455 2004
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker group BEFREE In the present study, we examined the effect of nerve growth factor (NGF) on IFN-gamma-induced TrkA protein to clarify the relationship between TrkA and cell differentiation of NB. 10842245 2000
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 GeneticVariation group BEFREE Detection of DNA polymorphisms and point mutations of high-affinity nerve growth factor receptor (TrkA) in human neuroblastoma. 10200344 1999