Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Brain-derived neurotropic factor (BDNF), a neurotrophic factor, plays important regulatory roles in depression by its high-affinity tropomysin-related kinase B (TrkB) receptor.
|
31660632 |
2020 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Brain derived neurotrophic factor (BDNF) and signaling through its tropomyosin-related tyrosine kinase B (TrkB) receptor, represents one of the most promising therapeutic targets for treating depression.
|
30931847 |
2019 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
To investigate the expression of brain-derived neurotrophic factor(BDNF) and tyrosine kinase B (TrkB) protein in the hippocampus of model rats of comorbid epilepsy and depression.
|
30741614 |
2019 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, the interaction between the BDNF/TRKB system and RAS in depression has not been investigated before.
|
29550391 |
2018 |
Mental Depression
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Meanwhile, viral-mediated overexpression of truncated trkB in the ventral hippocampus reduced local ERK42/44 phosphorylation and was sufficient to induce habit-based and depression-like behaviors.
|
29186135 |
2017 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Several nominally significant gene-based associations were detected, but only DICER1 associated with suicidal behavior in both samples, while only the associations of NTRK2 in the depression sample reached family wise and experiment wise significance.
|
26921221 |
2016 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
We report that BDNF and selective tyrosine kinase receptor B (TrkB) agonist 7,8-dihydroxyflavone (DHF) activated the TrkB receptor to facilitate two forms of eCB-mediated synaptic depression, depolarization-induced suppression of inhibition (DSI), and long-term depression (I-LTD) of IPSCs in ventral tegmental area dopamine neurons in mouse midbrain slices.
|
25762688 |
2015 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Polymorphisms of the brain-derived neurotrophic factor (BDNF) have been investigated as candidate genes for post-stroke depression (PSD), and its receptor, neurotrophic tyrosine kinase receptor B (TrkB), has been associated with depression.
|
26641254 |
2015 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
An interactive effect was found between NTRK2 and depression diagnosis maximally affecting the cingulum.
|
22609366 |
2012 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
An interactive effect was found between NTRK2 and depression diagnosis maximally affecting the cingulum.
|
22609366 |
2012 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Genetic variation associated with reduced function in the CREB1-BDNF-NTRK2 pathway has multiple, sometimes opposing, influences on risk mechanisms of depression, but almost all the SNPs studied amplified the effect of childhood adversity.
|
21215389 |
2011 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
RGD |
[Effects of chaihu shugan powder on the behavior and expressions of BDNF and TrkB in the hippocampus, amygdala, and the frontal lobe in rat model of depression].
|
22097208 |
2011 |
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association of nine polymorphisms throughout the CREB1-BDNF-NTRK2 pathway with lifetime depression, rumination, current depression severity, negative life events, and sad face emotion processing in a three-level design.
|
21215389 |
2011 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
The results suggest that the BDNF and NTRK2 genes may contribute to the risk of geriatric depression independently and in an interactive manner.
|
20014955 |
2009 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
This study examines the main effects of single loci and multilocus interactions to test the hypothesis that the BDNF and NTRK2 genes may contribute to the etiology of geriatric depression independently and/or through complex interactions.
|
20014955 |
2009 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
After controlling for age, gender and baseline 21-item Hamilton Depression Rating Scale (HAM-D21) score, as well as correcting for multiple testing, the relative reduction of HAM-D21 score remained significantly associated with two NTRK2-coding SNPs (rs2289657 and rs56142442) and the haplotype CAG at rs2289658 (splice site), rs2289657 and rs2289656.
|
19844206 |
2009 |