Unipolar Depression
|
0.340 |
Biomarker
|
disease |
BEFREE |
Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase B (TrkB), have emerged as key regulators of brain plasticity and represent disease-modifying targets for several brain disorders, including Alzheimer's disease and major depressive disorder.
|
28831019 |
2017 |
Unipolar Depression
|
0.340 |
Biomarker
|
disease |
PSYGENET |
The role of BDNF, NTRK2 gene and their interaction in development of treatment-resistant depression: data from multicenter, prospective, longitudinal clinic practice.
|
23137999 |
2013 |
Unipolar Depression
|
0.340 |
Biomarker
|
disease |
PSYGENET |
Brain-derived neurotrophic factor signaling and subgenual anterior cingulate cortex dysfunction in major depressive disorder.
|
23128924 |
2012 |
Unipolar Depression
|
0.340 |
Biomarker
|
disease |
PSYGENET |
The aim of this study was to examine whether the NTRK2 and BDNF polymorphisms impact brain white matter connections in major depressive disorder and whether they may also have an interactive effect with environmental stress in the form of early life adversity.
|
22609366 |
2012 |
Unipolar Depression
|
0.340 |
Biomarker
|
disease |
PSYGENET |
We analyzed 62 genotyped variants within the selected genes (BDNF, NTRK2, SLC6A4, TPH2, P2RX7, DAOA, COMT, DISC1, and MAOA) against the presence of mood disorder, and in post-hoc analyses, specifically against bipolar disorder or major depressive disorder.
|
21438144 |
2011 |
Unipolar Depression
|
0.340 |
Biomarker
|
disease |
PSYGENET |
Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans.
|
19844206 |
2009 |
Unipolar Depression
|
0.340 |
Biomarker
|
disease |
BEFREE |
Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans.
|
19844206 |
2009 |
Unipolar Depression
|
0.340 |
Biomarker
|
disease |
BEFREE |
Moreover, five (Htr2a, Ntrk3, Crhr1, Ntrk2 and Crh) of the genes classically related to human major depression were differentially expressed in at least one of these models.
|
18363858 |
2008 |
Unipolar Depression
|
0.340 |
Biomarker
|
disease |
BEFREE |
We tested for association of NTRK2 with COMD in two independent samples: (a) a case-control sample matched on ethnicity and gender, consisting of 120 cases who met DSM III/IV criteria for major depressive or dysthymic disorder before age 14 or bipolar I/II before the age of 18, and controls, and (b) a family based control sample of 113 families collected in Hungary, identified by a proband between the age of 7 and 14 who met DSM IV criteria for major depressive disorder or bipolar I/II disorder.
|
15389758 |
2005 |