Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.380 GeneticVariation disease BEFREE In 624 patients currently experiencing an MDE in the context of Major Depressive Disorder (MDD) (METADAP study), we assessed the association between 8 TRKB genetic polymorphisms (rs1778933, rs1187352, rs2289658, rs2289657, rs2289656, rs3824519, rs56142442 and rs1439050) and acute (previous month) or past (older than one month) SA. 30308049 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.380 Biomarker disease BEFREE Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase B (TrkB), have emerged as key regulators of brain plasticity and represent disease-modifying targets for several brain disorders, including Alzheimer's disease and major depressive disorder. 28831019 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.380 Biomarker disease BEFREE Here, we measured serum levels of tPA, plasminogen activator inhibitor-1 (PAI-1), BDNF, precursor-BDNF (proBDNF), tropomyosin-related kinase B (TrkB) and neurotrophin receptor p75 (p75NTR) in patients with paranoid schizophrenia (SZ, n = 34), MDD (n = 30), bipolar mania (BM, n = 30), bipolar depression (BD, n = 22), panic disorder (PD, n = 30), and healthy controls (HCs, n = 30) by Enzyme-linked immunosorbent assay kits. 28761093 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.380 Biomarker disease PSYGENET These results suggest that the interactions of BDNF (rs6265) with NTRK2 (rs1387923, rs2769605 and rs1565445) gene polymorphisms likely play an essential role in the development of TRD in Han Chinese MDD patients. 23137999 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.380 GeneticVariation disease BEFREE These results suggest that the interactions of BDNF (rs6265) with NTRK2 (rs1387923, rs2769605 and rs1565445) gene polymorphisms likely play an essential role in the development of TRD in Han Chinese MDD patients. 23137999 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.380 Biomarker disease PSYGENET Brain-derived neurotrophic factor signaling and subgenual anterior cingulate cortex dysfunction in major depressive disorder. 23128924 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.380 Biomarker disease PSYGENET The aim of this study was to examine whether the NTRK2 and BDNF polymorphisms impact brain white matter connections in major depressive disorder and whether they may also have an interactive effect with environmental stress in the form of early life adversity. 22609366 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.380 Biomarker disease PSYGENET We analyzed 62 genotyped variants within the selected genes (BDNF, NTRK2, SLC6A4, TPH2, P2RX7, DAOA, COMT, DISC1, and MAOA) against the presence of mood disorder, and in post-hoc analyses, specifically against bipolar disorder or major depressive disorder. 21438144 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.380 Biomarker disease BEFREE Associations of SNPs in BDNF and NTRK2 with SA and MDD. 20124106 2010
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.380 Biomarker disease PSYGENET Several SNPs or haplotypes in ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1 and NTRK2 were associated with MDD, and in ABCB1, SLC6A2 and NTRK2 with antidepressant response. 19844206 2009
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.380 Biomarker disease BEFREE Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans. 19844206 2009
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.380 Biomarker disease BEFREE Moreover, five (Htr2a, Ntrk3, Crhr1, Ntrk2 and Crh) of the genes classically related to human major depression were differentially expressed in at least one of these models. 18363858 2008
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.380 Biomarker disease BEFREE We tested for association of NTRK2 with COMD in two independent samples: (a) a case-control sample matched on ethnicity and gender, consisting of 120 cases who met DSM III/IV criteria for major depressive or dysthymic disorder before age 14 or bipolar I/II before the age of 18, and controls, and (b) a family based control sample of 113 families collected in Hungary, identified by a proband between the age of 7 and 14 who met DSM IV criteria for major depressive disorder or bipolar I/II disorder. 15389758 2005