Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 AlteredExpression disease BEFREE P<i>ostmortem</i> DLPFC expression data analysis showed decreased expression levels of NURR1 and ERR1 in patients with SCZ. 31811028 2020
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker disease BEFREE These findings should stimulate future studies to probe the ligandability and druggability of Nurr1 for both endogenous and synthetic ligands, which could lead to new therapeutics for Nurr1-related diseases, including Parkinson's disease and schizophrenia. 30416039 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 GeneticVariation disease BEFREE NURR1 alterations have been linked to DA-associated brain disorders, such as Parkinson's disease and schizophrenia. 31455763 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker disease BEFREE In parallel, NURR1 has been also linked to dopamine-associated brain disorders, such as Parkinson's disease (PD) and schizophrenia, since it is involved in the development and in the maintenance of midbrain dopaminergic neurons (mDA). 31574937 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 AlteredExpression disease BEFREE We detected decreased expression of RARG and NR4A2 mRNAs in females with schizophrenia (p<0.05). 27992436 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 GeneticVariation disease BEFREE The results failed to reveal significant link between NR4A2 polymorphism and SZ risk. 25982322 2015
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker disease BEFREE Our aim was to evaluate the influence of NR4A2 gene in the performance of schizophrenia (SZ) patients and healthy subjects on a sustained attention task. 22294735 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker disease PSYGENET Our findings thus suggest that heterozygous constitutive deletion of Nurr1 results in a restricted phenotype characteristic of schizophrenia symptomatology, which primarily relates to motor activity, sensorimotor gating and responsiveness to the psychomimetic drug MK-801. 21545404 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker disease PSYGENET The nuclear receptor Nurr1 functions to regulate dopamine neurotransmission, as Nurr1-null heterozygous (+/-) mice have alterations in dopamine function and, when raised in isolation immediately after weaning, have disruptions in sensorimotor gaiting, a behavior altered in schizophrenia and modulated by dopamine neurotransmission. 18655117 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker disease PSYGENET This suggests that the Nurr1 mutant mouse may be a potential animal model for studies on some of the behavioral and molecular mechanisms underlying schizophrenia. 17457314 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker disease MGD This suggests that the Nurr1 mutant mouse may be a potential animal model for studies on some of the behavioral and molecular mechanisms underlying schizophrenia. 17457314 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker disease PSYGENET These data show a deficient prefrontal NGFI-B and Nurr1 expression in schizophrenia and bipolar disorder. 16631355 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 AlteredExpression disease BEFREE These data show a deficient prefrontal NGFI-B and Nurr1 expression in schizophrenia and bipolar disorder. 16631355 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker disease BEFREE We conclude that structural variants in the RAR/RXR and NURR1 genes do not play a major role in the etiology of schizophrenia. 15635645 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker disease PSYGENET Evidence by others support this hypothesis (1) mapping of the NR4A2 gene to chromosome 2q22-23, a region with suggestive linkage to schizophrenia and (2) identification of mutations in patients with schizophrenia (c.366-369delTAC, c.308A > G, c.-469delG), manic depression (c.289A > G), and familial Parkinson's disease (c.-291delT, c.-245T > G). 15211629 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 GeneticVariation disease BEFREE Evidence by others support this hypothesis (1) mapping of the NR4A2 gene to chromosome 2q22-23, a region with suggestive linkage to schizophrenia and (2) identification of mutations in patients with schizophrenia (c.366-369delTAC, c.308A > G, c.-469delG), manic depression (c.289A > G), and familial Parkinson's disease (c.-291delT, c.-245T > G). 15211629 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 GeneticVariation disease LHGDN Evidence by others support this hypothesis (1) mapping of the NR4A2 gene to chromosome 2q22-23, a region with suggestive linkage to schizophrenia and (2) identification of mutations in patients with schizophrenia (c.366-369delTAC, c.308A > G, c.-469delG), manic depression (c.289A > G), and familial Parkinson's disease (c.-291delT, c.-245T > G). 15211629 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker disease BEFREE We conclude that the identified polymorphic sites in the human NURR1 are unlikely to be involved in conferring susceptibility for SZ or PD in our patient material. 12815740 2003
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 GeneticVariation disease BEFREE These data do not support the notion that the NR4A2 gene plays a major role in risk for schizophrenia among Japanese individuals. 12627459 2003
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 GeneticVariation disease LHGDN NURR1 promoter polymorphisms: Parkinson's disease, schizophrenia, and personality traits. 12815740 2003
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 GeneticVariation disease BEFREE The result suggests that the c.-469delG and possibly other variants of the NR4A2 gene may be of relevance to the complex factors involved in the pathogenesis of schizophrenia. 11803525 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 GeneticVariation disease LHGDN The result suggests that the c.-469delG and possibly other variants of the NR4A2 gene may be of relevance to the complex factors involved in the pathogenesis of schizophrenia. 11803525 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 GeneticVariation disease BEFREE NURR1 mutations in cases of schizophrenia and manic-depressive disorder. 11121187 2000
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 GeneticVariation disease BEFREE Further analysis of the polymorphism of the human Nurr1 gene may reveal the association with diseases characterized by changes of the DA system, such as Parkinson's disease and schizophrenia. 10216261 1999
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.340 AlteredExpression disease BEFREE NR4A2 expression in epithelials consecutively increased from adenoma, adjacent mucosa to CRC (P(trend)<0.001). 23809767 2013