Schizophrenia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
P<i>ostmortem</i> DLPFC expression data analysis showed decreased expression levels of NURR1 and ERR1 in patients with SCZ.
|
31811028 |
2020 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
These findings should stimulate future studies to probe the ligandability and druggability of Nurr1 for both endogenous and synthetic ligands, which could lead to new therapeutics for Nurr1-related diseases, including Parkinson's disease and schizophrenia.
|
30416039 |
2019 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
NURR1 alterations have been linked to DA-associated brain disorders, such as Parkinson's disease and schizophrenia.
|
31455763 |
2019 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
In parallel, NURR1 has been also linked to dopamine-associated brain disorders, such as Parkinson's disease (PD) and schizophrenia, since it is involved in the development and in the maintenance of midbrain dopaminergic neurons (mDA).
|
31574937 |
2019 |
Schizophrenia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We detected decreased expression of RARG and NR4A2 mRNAs in females with schizophrenia (p<0.05).
|
27992436 |
2016 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The results failed to reveal significant link between NR4A2 polymorphism and SZ risk.
|
25982322 |
2015 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our aim was to evaluate the influence of NR4A2 gene in the performance of schizophrenia (SZ) patients and healthy subjects on a sustained attention task.
|
22294735 |
2013 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Our findings thus suggest that heterozygous constitutive deletion of Nurr1 results in a restricted phenotype characteristic of schizophrenia symptomatology, which primarily relates to motor activity, sensorimotor gating and responsiveness to the psychomimetic drug MK-801.
|
21545404 |
2011 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
PSYGENET |
The nuclear receptor Nurr1 functions to regulate dopamine neurotransmission, as Nurr1-null heterozygous (+/-) mice have alterations in dopamine function and, when raised in isolation immediately after weaning, have disruptions in sensorimotor gaiting, a behavior altered in schizophrenia and modulated by dopamine neurotransmission.
|
18655117 |
2008 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
PSYGENET |
This suggests that the Nurr1 mutant mouse may be a potential animal model for studies on some of the behavioral and molecular mechanisms underlying schizophrenia.
|
17457314 |
2007 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
MGD |
This suggests that the Nurr1 mutant mouse may be a potential animal model for studies on some of the behavioral and molecular mechanisms underlying schizophrenia.
|
17457314 |
2007 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
PSYGENET |
These data show a deficient prefrontal NGFI-B and Nurr1 expression in schizophrenia and bipolar disorder.
|
16631355 |
2006 |
Schizophrenia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These data show a deficient prefrontal NGFI-B and Nurr1 expression in schizophrenia and bipolar disorder.
|
16631355 |
2006 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
We conclude that structural variants in the RAR/RXR and NURR1 genes do not play a major role in the etiology of schizophrenia.
|
15635645 |
2005 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Evidence by others support this hypothesis (1) mapping of the NR4A2 gene to chromosome 2q22-23, a region with suggestive linkage to schizophrenia and (2) identification of mutations in patients with schizophrenia (c.366-369delTAC, c.308A > G, c.-469delG), manic depression (c.289A > G), and familial Parkinson's disease (c.-291delT, c.-245T > G).
|
15211629 |
2004 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Evidence by others support this hypothesis (1) mapping of the NR4A2 gene to chromosome 2q22-23, a region with suggestive linkage to schizophrenia and (2) identification of mutations in patients with schizophrenia (c.366-369delTAC, c.308A > G, c.-469delG), manic depression (c.289A > G), and familial Parkinson's disease (c.-291delT, c.-245T > G).
|
15211629 |
2004 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Evidence by others support this hypothesis (1) mapping of the NR4A2 gene to chromosome 2q22-23, a region with suggestive linkage to schizophrenia and (2) identification of mutations in patients with schizophrenia (c.366-369delTAC, c.308A > G, c.-469delG), manic depression (c.289A > G), and familial Parkinson's disease (c.-291delT, c.-245T > G).
|
15211629 |
2004 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
We conclude that the identified polymorphic sites in the human NURR1 are unlikely to be involved in conferring susceptibility for SZ or PD in our patient material.
|
12815740 |
2003 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These data do not support the notion that the NR4A2 gene plays a major role in risk for schizophrenia among Japanese individuals.
|
12627459 |
2003 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
NURR1 promoter polymorphisms: Parkinson's disease, schizophrenia, and personality traits.
|
12815740 |
2003 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The result suggests that the c.-469delG and possibly other variants of the NR4A2 gene may be of relevance to the complex factors involved in the pathogenesis of schizophrenia.
|
11803525 |
2001 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
The result suggests that the c.-469delG and possibly other variants of the NR4A2 gene may be of relevance to the complex factors involved in the pathogenesis of schizophrenia.
|
11803525 |
2001 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
NURR1 mutations in cases of schizophrenia and manic-depressive disorder.
|
11121187 |
2000 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Further analysis of the polymorphism of the human Nurr1 gene may reveal the association with diseases characterized by changes of the DA system, such as Parkinson's disease and schizophrenia.
|
10216261 |
1999 |
Colorectal Carcinoma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
NR4A2 expression in epithelials consecutively increased from adenoma, adjacent mucosa to CRC (P(trend)<0.001).
|
23809767 |
2013 |