Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.300 GeneticVariation disease BEFREE NURR1 alterations have been linked to DA-associated brain disorders, such as Parkinson's disease and schizophrenia. 31455763 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.300 Biomarker disease BEFREE Bis-indole derivatives including 1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane (DIM-C-pPhCl) and substituted quinolines such as chloroquine (CQ) and amodiaquine (AQ) are nuclear receptor 4A2 (NR4A2, Nurr1) ligands, and they exhibit anti-inflammatory activities in mouse and rat models of Parkinson's disease, respectively. 31102570 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.300 Biomarker disease BEFREE Altogether, the enhancement of tyrosine hydroxylase in naïve dopaminergic cells and the protective effects in a cellular model of Parkinson's disease suggest that full-length Nurr1 fusion protein may contribute to the development of a novel concept of protein-based therapy. 30121937 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.300 Biomarker disease BEFREE In parallel, NURR1 has been also linked to dopamine-associated brain disorders, such as Parkinson's disease (PD) and schizophrenia, since it is involved in the development and in the maintenance of midbrain dopaminergic neurons (mDA). 31574937 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.300 Biomarker disease BEFREE These findings should stimulate future studies to probe the ligandability and druggability of Nurr1 for both endogenous and synthetic ligands, which could lead to new therapeutics for Nurr1-related diseases, including Parkinson's disease and schizophrenia. 30416039 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.300 Biomarker disease BEFREE The orphan nuclear receptor Nurr1 (also known as NR4A2) is critical for the development and maintenance of midbrain dopaminergic neurons, and is associated with Parkinson's disease. 30515963 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.300 Biomarker disease BEFREE In conclusion, the present study suggests that ABZ exerts a neuroprotective effect in a rotenone-induced PD model associated with HIF-1α and Nurr1 activation and thus may be a viable candidate for treating PD. 31408200 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.300 AlteredExpression disease BEFREE Minocycline Protects against Rotenone-Induced Neurotoxicity Correlating with Upregulation of Nurr1 in a Parkinson's Disease Rat Model. 30949504 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.300 AlteredExpression disease BEFREE Since decrease in Nurr1 function either due to diminished expression or rare mutation is associated with Parkinson's disease (PD), upregulation of Nurr1 may be beneficial for PD. 31127527 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.300 Biomarker disease BEFREE Here, we investigated the protective effects of CP on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP-) induced PD in mice and explored the underlying mechanisms of action, focusing on Nurr1. 31772707 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.300 Biomarker disease BEFREE Furthermore, peripheral Nurr1 was significantly decreased in PD compared with HC (56%, p < 0.001) and NDC (58%, p < 0.001). 30817108 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.300 Biomarker disease BEFREE These findings suggest avenues for developing synthetic Nurr1 ligands to ameliorate the symptoms and progression of Parkinson's disease. 30853418 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.300 Biomarker disease BEFREE Development of a novel NURR1/NOT agonist from hit to lead and candidate for the potential treatment of Parkinson's disease. 30773432 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.300 Biomarker disease BEFREE The nuclear receptor Nurr1 (NR4A2) has been identified as a potential target for the treatment of Parkinson's disease. 30582418 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.300 AlteredExpression disease BEFREE Ectopic NR4A2 expression has been reported to be related with familial Parkinson disease, and through dual luciferase we found that NR4A2 is a target gene of microRNA-183 (miR-183). 30191980 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.300 Biomarker disease BEFREE Neuroprotective effect of olfactory ensheathing cells co-transfected with Nurr1 and Ngn2 in both in vitro and in vivo models of Parkinson's disease. 29291419 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.300 Biomarker disease BEFREE Taken together, these data suggest that C-DIM12 is an activator of Nurr1 that suppresses glial activation and neuronal loss in vivo after treatment with MPTP, and that this receptor could be an efficacious target for disease modification in individuals with Parkinson's disease and related disorders. 29626009 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.300 AlteredExpression disease BEFREE Graphical Abstract In the rat rotenone model of Parkinson's disease (PD), Nurr1 expression was downregulated, GSK-3β was activated, and autophagic flux was inhibited. 29429051 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.300 Biomarker disease BEFREE The delivery of PLs-GDNF + Nurr1-MBs into the brains using magnetic resonance imaging (MRI)-guided focused ultrasound may be more efficacious for the treatment of PD than the single treatment. 29240240 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.300 AlteredExpression disease BEFREE These phenomena provided a new theoretical and experimental foundation for the transplantation of Nurr1-overexpressed NSCs as a potential treatment of PD. 29450981 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.300 AlteredExpression disease BEFREE In a rat model of Parkinson's disease (PD), cografting NPCs with midbrain-derived astrocytes engineered to overexpress the transcription factors Nurr1 and Foxa2 promotes maturation and survival of the graft, resulting in therapeutic improvement. 29227287 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.300 Biomarker disease BEFREE Taken together, these findings suggest that intrastriatal transplantation of lentiviral vector mediated Nurr1 gene-modified MSCs has notable therapeutic effect for PD rats. 30018702 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.300 Biomarker disease BEFREE Modulatory Role of Nurr1 Activation and Thrombin Inhibition in the Neuroprotective Effects of Dabigatran Etexilate in Rotenone-Induced Parkinson's Disease in Rats. 28585189 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.300 Biomarker disease BEFREE Nuclear receptor related 1 (NURR1) is an essential protein for maintenance of dopaminergic neurons in adult midbrain of which deficiency leads to Parkinson's disease. 28452458 2017
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.300 Biomarker disease BEFREE Nurr1 is a member of the nuclear receptor 4 family of orphan nuclear receptors that is decreased in inflammatory responses and leads to neurons death in Parkinson's disease. 29209166 2017