Parkinson Disease
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
NURR1 alterations have been linked to DA-associated brain disorders, such as Parkinson's disease and schizophrenia.
|
31455763 |
2019 |
Parkinson Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Bis-indole derivatives including 1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane (DIM-C-pPhCl) and substituted quinolines such as chloroquine (CQ) and amodiaquine (AQ) are nuclear receptor 4A2 (NR4A2, Nurr1) ligands, and they exhibit anti-inflammatory activities in mouse and rat models of Parkinson's disease, respectively.
|
31102570 |
2019 |
Parkinson Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Altogether, the enhancement of tyrosine hydroxylase in naïve dopaminergic cells and the protective effects in a cellular model of Parkinson's disease suggest that full-length Nurr1 fusion protein may contribute to the development of a novel concept of protein-based therapy.
|
30121937 |
2019 |
Parkinson Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
In parallel, NURR1 has been also linked to dopamine-associated brain disorders, such as Parkinson's disease (PD) and schizophrenia, since it is involved in the development and in the maintenance of midbrain dopaminergic neurons (mDA).
|
31574937 |
2019 |
Parkinson Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
These findings should stimulate future studies to probe the ligandability and druggability of Nurr1 for both endogenous and synthetic ligands, which could lead to new therapeutics for Nurr1-related diseases, including Parkinson's disease and schizophrenia.
|
30416039 |
2019 |
Parkinson Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
The orphan nuclear receptor Nurr1 (also known as NR4A2) is critical for the development and maintenance of midbrain dopaminergic neurons, and is associated with Parkinson's disease.
|
30515963 |
2019 |
Parkinson Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
In conclusion, the present study suggests that ABZ exerts a neuroprotective effect in a rotenone-induced PD model associated with HIF-1α and Nurr1 activation and thus may be a viable candidate for treating PD.
|
31408200 |
2019 |
Parkinson Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Minocycline Protects against Rotenone-Induced Neurotoxicity Correlating with Upregulation of Nurr1 in a Parkinson's Disease Rat Model.
|
30949504 |
2019 |
Parkinson Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Since decrease in Nurr1 function either due to diminished expression or rare mutation is associated with Parkinson's disease (PD), upregulation of Nurr1 may be beneficial for PD.
|
31127527 |
2019 |
Parkinson Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Here, we investigated the protective effects of CP on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP-) induced PD in mice and explored the underlying mechanisms of action, focusing on Nurr1.
|
31772707 |
2019 |
Parkinson Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Furthermore, peripheral Nurr1 was significantly decreased in PD compared with HC (56%, p < 0.001) and NDC (58%, p < 0.001).
|
30817108 |
2019 |
Parkinson Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
These findings suggest avenues for developing synthetic Nurr1 ligands to ameliorate the symptoms and progression of Parkinson's disease.
|
30853418 |
2019 |
Parkinson Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Development of a novel NURR1/NOT agonist from hit to lead and candidate for the potential treatment of Parkinson's disease.
|
30773432 |
2019 |
Parkinson Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
The nuclear receptor Nurr1 (NR4A2) has been identified as a potential target for the treatment of Parkinson's disease.
|
30582418 |
2019 |
Parkinson Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Ectopic NR4A2 expression has been reported to be related with familial Parkinson disease, and through dual luciferase we found that NR4A2 is a target gene of microRNA-183 (miR-183).
|
30191980 |
2019 |
Parkinson Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Neuroprotective effect of olfactory ensheathing cells co-transfected with Nurr1 and Ngn2 in both in vitro and in vivo models of Parkinson's disease.
|
29291419 |
2018 |
Parkinson Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Taken together, these data suggest that C-DIM12 is an activator of Nurr1 that suppresses glial activation and neuronal loss in vivo after treatment with MPTP, and that this receptor could be an efficacious target for disease modification in individuals with Parkinson's disease and related disorders.
|
29626009 |
2018 |
Parkinson Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Graphical Abstract In the rat rotenone model of Parkinson's disease (PD), Nurr1 expression was downregulated, GSK-3β was activated, and autophagic flux was inhibited.
|
29429051 |
2018 |
Parkinson Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
The delivery of PLs-GDNF + Nurr1-MBs into the brains using magnetic resonance imaging (MRI)-guided focused ultrasound may be more efficacious for the treatment of PD than the single treatment.
|
29240240 |
2018 |
Parkinson Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
These phenomena provided a new theoretical and experimental foundation for the transplantation of Nurr1-overexpressed NSCs as a potential treatment of PD.
|
29450981 |
2018 |
Parkinson Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In a rat model of Parkinson's disease (PD), cografting NPCs with midbrain-derived astrocytes engineered to overexpress the transcription factors Nurr1 and Foxa2 promotes maturation and survival of the graft, resulting in therapeutic improvement.
|
29227287 |
2018 |
Parkinson Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings suggest that intrastriatal transplantation of lentiviral vector mediated Nurr1 gene-modified MSCs has notable therapeutic effect for PD rats.
|
30018702 |
2018 |
Parkinson Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Modulatory Role of Nurr1 Activation and Thrombin Inhibition in the Neuroprotective Effects of Dabigatran Etexilate in Rotenone-Induced Parkinson's Disease in Rats.
|
28585189 |
2018 |
Parkinson Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Nuclear receptor related 1 (NURR1) is an essential protein for maintenance of dopaminergic neurons in adult midbrain of which deficiency leads to Parkinson's disease.
|
28452458 |
2017 |
Parkinson Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Nurr1 is a member of the nuclear receptor 4 family of orphan nuclear receptors that is decreased in inflammatory responses and leads to neurons death in Parkinson's disease.
|
29209166 |
2017 |