OAS1, 2'-5'-oligoadenylate synthetase 1, 4938

N. diseases: 72; N. variants: 11
Disease: Sjogren's Syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.030 GeneticVariation disease BEFREE Publisher Correction: A functional variant in the OAS1 gene is associated with Sjögren's syndrome complicated with HBV infection. 30429517 2018
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.030 GeneticVariation disease BEFREE A functional variant in the OAS1 gene is associated with Sjögren's syndrome complicated with HBV infection. 29242559 2017
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.030 GeneticVariation disease BEFREE Our results establish OAS1 as a risk locus for SS and support a potential role for defective viral clearance due to altered IFN response as a genetic pathophysiological basis of this complex autoimmune disease. 28640813 2017