|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.640 |
GeneticVariation
|
disease |
BEFREE |
We hypothesized that variants in the hOGG1 gene are associated with risk of renal cell carcinoma (RCC).
|
21166493 |
2011 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.640 |
GeneticVariation
|
disease |
BEFREE |
Loss of heterozygosity at the 8-oxoG-DNA glycosylase (OGG1) allele is found in human kidney clear cell carcinoma identifying loss of OGG1 function as a possible contributor to tumorigenesis in the kidney.
|
19265534 |
2009 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.640 |
Biomarker
|
disease |
BEFREE |
It is concluded that deletion of hOGG1 gene occurs commonly in PRCC and CC-RCC but not in renal cortical PA. Further studies are warranted to further explore the exact roles of hOGG1 gene in the development and progression of RCC.
|
18477212 |
2008 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.640 |
AlteredExpression
|
disease |
BEFREE |
We investigated, by an immunohistochemical staining method, the expression of hOGG1 protein in 40 cases of CC-RCC, using archival formalin-fixed tissue.
|
14663360 |
2003 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.640 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.640 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.640 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Renal Cell Carcinoma
|
0.620 |
GeneticVariation
|
disease |
BEFREE |
We hypothesized that variants in the hOGG1 gene are associated with risk of renal cell carcinoma (RCC).
|
21166493 |
2011 |
|
Renal Cell Carcinoma
|
0.620 |
Biomarker
|
disease |
RGD |
In addition, the predominant expression of OGG1 in the cortex and its decreased expression and activity in the Eker rat may account for the predominant cortical localization of renal cell carcinoma.
|
18218111 |
2008 |
|
Renal Cell Carcinoma
|
0.620 |
AlteredExpression
|
disease |
LHGDN |
Concomitant loss of mitochondria and the DNA repair protein hOGG1 in clear cell carcinoma of the kidney.
|
14663360 |
2003 |
|
Renal Cell Carcinoma
|
0.620 |
Biomarker
|
disease |
HPO |
|
|
|
|
Renal Cell Carcinoma
|
0.620 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Malignant neoplasm of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Using the multifactor dimensionality reduction method, we found a model of gene-gene interactions associated with the risk of lung cancer: NBS1 (rs1805794)-XRCC1 (rs25487)-hOGG1 (rs1052133)-XPG (rs17655).
|
31584889 |
2019 |
|
Malignant neoplasm of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
OGG1 presented a high risk towards lung cancer (CG: OR = 2.44, p = 0.0003; CG + GG: OR = 1.88, p = 0.0093).
|
29209987 |
2019 |
|
Malignant neoplasm of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Thus, analysis of the mechanism by which OGG1 modulates gene expression helps discern between beneficial and detrimental effects of oxidant stress, exposes a missing functional link as a marker, and yields a novel target for lung cancer.
|
30240635 |
2019 |
|
Malignant neoplasm of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To analyze the relationship of GSTT1, GSTM1, XRCC1 (rs25487), ERCC1 (rs11615, rs3212986), ERCC2 (rs13181), XRCC3 (rs861539), OGG1 (rs1052133), and Alpha-1-Antitrypsin mutations (AAT) with the risk of lung cancer in never-smokers, and ascertain if there is an effect modification between these polymorphisms and residential radon exposure.
|
31446980 |
2019 |
|
Malignant neoplasm of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Importantly, it can be applied for the detection of enzyme kinetic parameters, the screening of hOGG1 inhibitors, and the quantification of hOGG1 activity in even 1 single lung cancer cell, providing a new approach for biomedical research and clinical diagnosis.
|
30460848 |
2018 |
|
Malignant neoplasm of prostate
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results support the hypotheses that those who develop PC have significantly higher level of genomic instability which is further increased in those who carry G allele of the hOGG1 (C1245G) polymorphism..
|
30264500 |
2018 |
|
Malignant neoplasm of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we investigated the polymorphisms of the following selected members of the base and nucleotide excision repair genes: XPC (Lys939Gln), XPD (Lys751Gln), XRCC1(Arg399Gln), and hOGG1(Ser326Ser), and the risk they present toward the development of lung cancer, with emphasis on the effect of chromium exposure.
|
25300687 |
2015 |
|
Malignant neoplasm of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
The hOGG1 and NTH1 genes act in the DNA BER repair pathway and their involvement in lung cancer pathogenesis has been analyzed in several populations.
|
26400813 |
2015 |
|
Malignant neoplasm of prostate
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Less common alleles of rs11913319 in TXNRD2 and rs125701 in OGG1 were associated with an increased risk of high-grade prostate cancer.
|
25284284 |
2015 |
|
Malignant neoplasm of prostate
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we suggest that the hOGG1 C1245G polymorphism might be potentially associated with Pca risk in different ethnicities and countries, especially among Asians.
|
25907663 |
2015 |
|
Malignant neoplasm of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis revealed that there was little correlation between the hOGG1 Ser326Cys polymorphism and the risk of lung cancer.
|
24435978 |
2014 |
|
Malignant neoplasm of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Despite some limitations, this meta-analysis provides solid evidence that hOGG1 Ser326Cys polymorphism may contribute to lung cancer risk, particularly for Asian populations, never smokers, and more-cigarette takers.
|
24085357 |
2014 |
|
Malignant neoplasm of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data showed that the hOGG1 Ser326Cys polymorphism contributed to the risk of lung cancer.
|
23971971 |
2013 |