|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggest that in MDD, immune activation is associated with a simultaneous activation of dynorphin/KOR and β-endorphin/MOR signaling and that these opioid systems may participate in the pathophysiology of depression by a) exerting immune regulatory activities attenuating the primary immune response; and b) modulating reward responses and mood as well as emotional and behavioral responses to stress.
|
31753054 |
2020 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
The kappa opioid receptor (KOR) is a drug target for diseases involving mood and reward, such as depression and addiction.
|
31313902 |
2019 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
The kappa opioid receptor (KOR) is involved in depression, alcoholism, and drug abuse.
|
30726092 |
2019 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the last years several molecules, able to interact with KOR, have been the focus of basic research for their therapeutic potential in the field of chronic pain, as well as in depression, autoimmune disorders and neurological diseases.
|
30666905 |
2019 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
The κ-opioid receptor (KOR) has been implicated in depression, addictions, and other central nervous system disorders and, thus, is an important target for drug development.
|
28747521 |
2018 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
There is growing evidence that kappa opioid receptor (KOR) antagonists could be a useful class of therapeutics for treating depression and anxiety.
|
29491835 |
2018 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mesyl Salvinorin B (MSB) is a potent selective kappa opioid receptor (KOP-r) agonist that has potential for development as an anti-psychostimulant agent with fewer side-effects (e.g., sedation, depression and dysphoria) than classic KOP-r agonists.
|
28263712 |
2017 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Ghr administration on the expression of hypothalamic genes related to depression and mood (delta opioid receptor (DOR), mu opioid receptor (MOR) and kappa opioid receptor (KOR), lutropin-choriogonadotropic hormone receptor (LHCGR), serotonin transporter (SERT), interleukin 1 beta (IL-1b), vasopressin (AVP) and corticotrophin releasing hormone (CRH)) in OB animals, as well as changes in plasma levels of AVP, CRH and adenocorticotropic hormone (ACTH).
|
25286107 |
2015 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Novel κ-opioid receptor agonist MB-1C-OH produces potent analgesia with less depression and sedation.
|
25816912 |
2015 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Roles of nucleus accumbens CREB and dynorphin in dysregulation of motivation.
|
23293139 |
2013 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although elevated levels of transcriptionally active CREB appear to attenuate DA transmission by increasing expression of the endogenous κ opioid receptor (KOR) ligand dynorphin, increased dynorphin transmission may ultimately have undesirable effects that contribute to drug withdrawal states as well as comorbid psychiatric illnesses such as depression.
|
23293139 |
2013 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
We genotyped 23 single nucleotide polymorphisms (SNPs) in the PDYN and OPRK1 genes in 816 alcohol-dependent subjects and investigated their association with: (1) negative craving measured by a subscale of the Inventory of Drug Taking Situations; (2) a self-reported history of depression; (3) the intensity of depressive symptoms measured by the Beck Depression Inventory-II.
|
23101464 |
2013 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
We genotyped 23 single nucleotide polymorphisms (SNPs) in the PDYN and OPRK1 genes in 816 alcohol-dependent subjects and investigated their association with: (1) negative craving measured by a subscale of the Inventory of Drug Taking Situations; (2) a self-reported history of depression; (3) the intensity of depressive symptoms measured by the Beck Depression Inventory-II.
|
23101464 |
2013 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Previous research showing increased kappa-opioid receptor (KOR) gene expression in the brains of WKY rats, combined with studies implicating the KOR in animal models of depression and anxiety, suggests that alterations in the KOR system could have a role in the WKY behavioral phenotype.
|
19924112 |
2010 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
kappa-opioid receptor antagonists such as nor-Binaltorphimine (nor-BNI) have been shown to produce antidepressant-like behavioral effects in animal models of depression.
|
17601558 |
2007 |