OPRK1, opioid receptor kappa 1, 4986

N. diseases: 156; N. variants: 12
Disease: Withdrawal Symptoms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0087169
Disease: Withdrawal Symptoms
Withdrawal Symptoms 		0.320 Biomarker phenotype BEFREE Preclinical data indicate that selective kappa opioid receptor antagonists reduce nicotine self-administration and withdrawal symptoms. 31240842 2019
CUI: C0087169
Disease: Withdrawal Symptoms
Withdrawal Symptoms 		0.320 GeneticVariation phenotype BEFREE The association of genetic polymorphisms in the κ-opioid receptor 1 gene with body weight, alcohol use, and withdrawal symptoms in patients with methadone maintenance. 24525640 2014
CUI: C0087169
Disease: Withdrawal Symptoms
Withdrawal Symptoms 		0.320 Biomarker phenotype CTD_human Effect of the selective kappa-opioid receptor antagonist JDTic on nicotine antinociception, reward, and withdrawal in the mouse. 20232057 2010
CUI: C0087169
Disease: Withdrawal Symptoms
Withdrawal Symptoms 		0.320 Biomarker phenotype CTD_human Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal. 9463367 1998