|
Alcohol Use Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Three μ-opioid receptor gene (OPRM1) variants and two κ-opioid receptor gene (OPRK1) variants were examined in 314 male patients with AUD and 324 male controls.
|
31004399 |
2020 |
|
Alcohol Use Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
This single molecule localization microscopy technique was employed to quantitatively characterize the effects of pharmacologically relevant concentrations of ethanol and naltrexone (an opioid receptor antagonist and medication used to treat alcohol use disorders) on the lateral nano-organization of mu and kappa opioid receptors (MOR and KOR, respectively).
|
30418735 |
2019 |
|
Alcohol Use Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
We characterized the effects of the mu opioid peptide (MOP) receptor agonist buprenorphine and the buprenorphine analog (2S)-2-[(5R,6R,7R,14S)-N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6 methoxymorphinan-7-yl]-3,3-dimethylpentan-2-ol (BU08028), which stimulates MOP and NOP receptors, in a translational nonhuman primate model of AUD.
|
30970376 |
2019 |
|
Alcohol Use Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Some studies show that AUD patients carrying the G-allele of the OPRM1 variant c.118A>G respond better to naltrexone, resulting in reduced relapse rates compared to carriers of the AA genotype.
|
30384381 |
2018 |
|
Alcohol Use Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A functional polymorphism of the mu-opioid receptor gene (OPRM1 rs1799971" genes_norm="4988">A118G, rs1799971) may alter the risk of developing AUD.
|
29497164 |
2018 |
|
Alcohol Use Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
An association between AUD and a coding single nucleotide polymorphism (SNP) (rs1799971 encoding an rs1799971" genes_norm="4988">Asn40Asp amino acid substitution, rs1799971" genes_norm="4988">A118G) within the µ-opioid receptor 1 gene (OPRM1) has been reported.
|
25836994 |
2015 |
|
Alcohol Use Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The association between the OPRM1 A118G (rs1799971" genes_norm="4988">Asn40Asp, rs1799971) polymorphism and alcohol use disorders and alcohol consumption was analyzed using three different population-based samples: (a) a Finnish cohort study, Health 2000, with 503 participants having a DSM-IV diagnosis for alcohol dependence and/or alcohol abuse and 506 age- and sex-matched controls; (b) a Finnish cohort study, FINRISK (n = 2360) and (c) the Helsinki Birth Cohort Study (n = 1384).
|
23729673 |
2014 |
|
Alcohol Use Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study provides initial evidence that the association between the A118G SNP of the OPRM1 gene and risk of AUDs is moderated by modifiable factors.
|
23136901 |
2013 |
|
Alcohol Use Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study examined the interplay between the influence of peers who promote alcohol use and μ-opioid receptor M1 (OPRM1) genetic variation in the intergenerational transmission of alcohol use disorder (AUD) symptoms while separating the "traitlike" components of AUD symptoms from their age-specific manifestations at three ages from emerging adulthood (17-23 years) to adulthood (29-40 years).
|
22781865 |
2012 |
|
Alcohol Use Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Adolescents (n = 187; mean age = 15.4 years; 47.6% female) were genotyped for A118G (rs1799971), a single-nucleotide polymorphism (SNP) of the OPRM1 gene, and assessed for alcohol use disorder (AUD) diagnoses and other psychopathology.
|
19860800 |
2010 |
|
Alcohol Use Disorder
|
0.400 |
Biomarker
|
disease |
CTD_human |
Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans.
|
12815747 |
2003 |