OPRM1, opioid receptor mu 1, 4988

N. diseases: 370; N. variants: 42
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker disease BEFREE Further modification of this pendant resulted in retention of KOR agonism and the addition of mu opioid receptor (MOR) partial agonism, a bifunctional profile with potential to be used in the treatment of cocaine addiction. 31199621 2019
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker disease BEFREE Previous studies suggested that simultaneous activation of nociceptin opioid (NOP) and mu opioid (MOP) receptors could be a successful strategy to treat cocaine addiction, but the paucity of molecules co-activating both receptors with comparable potency has hampered this line of research. 29180970 2017
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker disease PSYGENET Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence. 22882391 2013
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker disease BEFREE Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence. 22882391 2013
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker disease CTD_human Increased brain mOR binding in frontal and temporal cortical regions is a significant independent predictor of time to relapse to cocaine use, suggesting an important role for the brain endogenous opioid system in cocaine addiction. 18762918 2008
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker disease CTD_human An antisense oligodeoxynucleotide to the mu opioid receptor attenuates cocaine-induced behavioral sensitization and reward in mice. 16893609 2006
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 GeneticVariation disease BEFREE Studies of polymorphisms in the mu opioid receptor gene, which encodes the receptor target of some endogenous opioids, heroin, morphine, and synthetic opioids, have contributed substantially to knowledge of genetic influences on opiate and cocaine addiction. 15734726 2005
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker disease PSYGENET Studies of polymorphisms in the mu opioid receptor gene, which encodes the receptor target of some endogenous opioids, heroin, morphine, and synthetic opioids, have contributed substantially to knowledge of genetic influences on opiate and cocaine addiction. 15734726 2005
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker disease CTD_human Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans. 12815747 2003
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker disease PSYGENET Using the human mu opioid receptor gene (OPRM1) as a model system, we have combined these approaches to test a potential role of OPRM1 in substance (heroin/cocaine) dependence. 11092766 2000
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker disease BEFREE Using the human mu opioid receptor gene (OPRM1) as a model system, we have combined these approaches to test a potential role of OPRM1 in substance (heroin/cocaine) dependence. 11092766 2000