|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
P2RX7 variants implying an increased pore activity were more common in bipolar disorder, in females but not in males.
|
30445384 |
2019 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Bipolar disorder and 1513A>C P2RX7 polymorphism frequency.
|
30521946 |
2019 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Comprehensive investigation of the P2X7R Gln460Arg missense mutation (rs2230912), which has been associated with major depression and bipolar disorder, has substantially contributed to validate P2X7R as a potential genetic risk factor.
|
30093269 |
2018 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that heterozygosity for the wild-type P2X7R and its mood disorder-associated variant P2X7R-Gln460Arg represents a genetic risk factor, which is potentially able to convey susceptibility to mood disorders.<b>SIGNIFICANCE STATEMENT</b> Depression and bipolar disorder are the most common mood disorders.
|
29079688 |
2017 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Sleep deprivation increased P2RX7 expression in healthy persons and the putatively low-activity P2RX7 rs2230912 allele A variant was associated with rapid cycling in bipolar disorder.
|
22952630 |
2012 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
There is an association between specific symptoms of bipolar disorder and the P2RX7 gene.
|
22017219 |
2012 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Although genetic findings were not always consistently replicated, several studies demonstrated that single nucleotide polymorphisms (SNPs) in the human P2X7 gene (P2RX7) show significant association with major depressive disorder and bipolar disorder.
|
23269209 |
2012 |
|
Bipolar Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
P2RX7: expression responds to sleep deprivation and associates with rapid cycling in bipolar disorder type 1.
|
22952630 |
2012 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
There is an association between specific symptoms of bipolar disorder and the P2RX7 gene.
|
22017219 |
2012 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Recent linkage studies have associated a polymorphism of the gene coding for the P2X7 receptor (P2X7R) with both major depressive disorder and bipolar disorder.
|
21664437 |
2011 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
We analyzed 62 genotyped variants within the selected genes (BDNF, NTRK2, SLC6A4, TPH2, P2RX7, DAOA, COMT, DISC1, and MAOA) against the presence of mood disorder, and in post-hoc analyses, specifically against bipolar disorder or major depressive disorder.
|
21438144 |
2011 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The P2RX7 gene (coding for P2X7 purinergic receptor) has been suggested as a novel candidate gene for major depressive disorder (MDD) and bipolar disorder (BPD).
|
18543274 |
2009 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The gene P2RX7 is located in this chromosomal region and has been recently reported as a susceptibility gene for bipolar disorder and unipolar depression.
|
19160446 |
2009 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The purinergic receptor gene P2RX(7) is located in a major linkage hotspot for schizophrenia and bipolar disorders, 12q21-33.
|
18614336 |
2008 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recent linkage studies have shown that the P2X7 gene is associated with major depression and bipolar disorder.
|
17558618 |
2007 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently, the immune-related gene encoding purinergic receptor P2X, ligand-gated ion channel, 7 (P2RX7) has been genetically associated with major depressive disorder and bipolar disorder.
|
17963976 |
2007 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A non-synonymous coding SNP in the P2RX7 gene (rs2230912), previously found to be associated with bipolar disorder, was significantly associated (P=0.0019) with MDD.
|
16822851 |
2006 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder.
|
16673375 |
2006 |