P2RX7, purinergic receptor P2X 7, 5027

N. diseases: 337; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker disease BEFREE Microglia-mediated neuroinflammation accompanies many central nervous system (CNS) diseases, including multiple sclerosis (MS), and is strongly dependent on the purinergic P2X7 receptor. 30209761 2019
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 AlteredExpression disease BEFREE In the neuroinflammatory foci of MS there is increased expression of a purinergic receptor, P2X7R. 30908981 2019
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker disease BEFREE In this review, we will summarize recent findings highlighting the potential of P2X4 and P2X7 as therapeutic targets for MS. 31015145 2019
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker disease BEFREE Purinergic receptor P2Y<sub>12</sub> (P2Y<sub>12</sub> ), a G protein-coupled purinergic receptor, is widely distributed in nervous system and involved in the progression of neurological diseases such as multiple sclerosis and neuropathic pain. 29341465 2019
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 AlteredExpression disease BEFREE In particular, ionotropic purinergic receptors P2X4 and P2X7 and metabotropic receptor P2Y12 are differently expressed along the disease and their activation or blockage modifies the course of texperimental autoimmune encephalomyelitis (EAE), the dominant animal model of MS. 30500565 2019
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker disease BEFREE Recently, numerous evidences further suggested the significance of P2X7R in the pathogenesis of autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), inflammatory bowel disease (IBD), multiple sclerosis (MS), etc. 31181327 2019
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker disease BEFREE Our study nominates rare genetic variants in P2RX4 and P2RX7 as major genetic contributors to disease, further supporting a role for these purinergic receptors in MS and the disruption of transmembrane cation channels leading to impairment of phagocytosis as the pathological mechanisms of disease. 28326637 2017
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker disease BEFREE Our results suggest that inhibition of P2X7R on monocytes and up-regulation in astrocytes might contribute to sustain inflammatory mechanisms in MS. By acquiring further knowledge about P2X7R dynamics and identifying P2X7R as a potential marker for the disease, we expect to gain insights into the molecular pathways of MS. 29187851 2017
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 AlteredExpression disease BEFREE In the current study, we further characterized its binding profile and determined whether [C]GSK1482160 can detect changes in P2X7R expression in a rodent model of multiple sclerosis. 28338530 2017
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation disease BEFREE Analysis shows Arg307Gln always occurred with 270His suggesting a single 307Gln-270His haplotype that confers dominant negative effects on P2X7 function and protection against MS. 26188005 2015
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation disease BEFREE Here, we have explored the putative association of functionally relevant single nucleotide polymorphisms of the P2X7 receptor gene with multiple sclerosis. 21906809 2011
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker disease CTD_human P2X(7) receptor blockade prevents ATP excitotoxicity in oligodendrocytes and ameliorates experimental autoimmune encephalomyelitis. 17728465 2007