Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
P2X7 receptors are important in the regulation of inflammatory responses and immune responses to intracellular pathogens such as Mycobacterium tuberculosis and Toxoplasma gondii.
|
30824738 |
2019 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We made a minireview on the association of many candidate genes with TB based on recent research studies systematically, such as the human leukocyte antigen (HLA) gene, the solute carrier family 11 member 1 (SLC11A1) gene system, the vitamin D receptor (VDR) gene, the mannan-binding lectin (MBL) gene, the nitric oxide synthase 2A (NOS2A) gene, the speckled 110 (SP110) gene, and the P2X7 receptor (P2X7) gene.
|
31485302 |
2019 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
P2X7 receptor polymorphisms and susceptibility to tuberculosis in a North Indian Punjabi population.
|
29991397 |
2018 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate whether the presence of P2X7 receptor in BM-derived cells contributes to TB severity, we generated chimeric mice by adoptive transfer of hematopoietic cells from C57BL/6 or P2X7<sup>-/-</sup> mice into CD45.1 irradiated mice.
|
28450867 |
2017 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We demonstrated that genetic variations of the P2X7 gene might be involved in the risk and prognosis of human tuberculosis.
|
28495473 |
2017 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of IFN-γ and P2X7 Receptor Gene Polymorphisms in Susceptibility to Tuberculosis Among Iranian Patients.
|
27020872 |
2016 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data evidence the novel association between polymorphisms in NLRP3-inflammasome encoding genes and active pulmonary TB, and replicated the association between P2X7 and TB observed in other populations.
|
27101784 |
2016 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Single Nucleotide Polymorphisms in P2X7 Gene Are Associated with Serum Immunoglobulin G Responses to Mycobacterium tuberculosis in Tuberculosis Patients.
|
26798189 |
2015 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus several preclinical studies demonstrate the involvement of the P2X7 receptor (P2X7R) in the control of Mycobacterium tuberculosis (MTB) infection.
|
26314826 |
2015 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate whether the innate immune response to damage signals could contribute to the development of pulmonary necrotic lesions in severe forms of tuberculosis, disease progression was examined in C57BL/6 and P2X7R-/- mice that were intratracheally infected with highly virulent mycobacterial strains (Mycobacterium tuberculosis strain 1471 of the Beijing genotype family and Mycobacterium bovis strain MP287/03).
|
24991816 |
2014 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The effect of P2X7 receptor 1513 polymorphism on susceptibility to tuberculosis: A meta-analysis.
|
24650918 |
2014 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Systematic assessment was performed for the published studies related with the association between the P2X7 1513 A>C polymorphism and TB risk retrieved from PubMed (Medline), EMBASE search.
|
23947898 |
2013 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A significant association of 762T/C and 1513A/C polymorphisms with TB in the P2X7 gene was found in our study population.
|
22137490 |
2012 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we investigate whether the P2X7 receptor plays a role in increasing susceptibility to tuberculosis in Tunisia.
|
21635566 |
2011 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms at the 1513 locus had a statistically significant association with P2X7 variants and tuberculosis susceptibility, while the -762 locus allele variants were not significantly associated with P2X7 variants and tuberculosis susceptibility.
|
20846359 |
2010 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of P2X7 receptor +1513 (A-->C) polymorphism with tuberculosis in a Punjabi population.
|
20819262 |
2010 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Several important candidate genes like human leucocyte antigen/alleles and non-human leucocyte antigen genes, such as cytokines and their receptors, chemokines and their receptors, pattern recognition receptors (including toll-like receptors, mannose binding lectin and the dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin), solute carrier family 11A member 1 (formerly known as natural resistance-associated macrophage protein 1) and purinergic P2X7 receptor gene polymorphisms, have been associated with differential susceptibility to TB in various ethnic populations.
|
20199642 |
2010 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, our analysis of P2X7 showed that the 1513A-->C and -762T-->C polymorphisms did not appear to be associated with the susceptibility of the Chinese Han population to tuberculosis.
|
19076224 |
2009 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Thus, our analysis of P2X7 showed that the 1513A-->C and -762T-->C polymorphisms did not appear to be associated with the susceptibility of the Chinese Han population to tuberculosis.
|
19076224 |
2009 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, analysis of the P2X(7) receptor gene in the Russian Slavic population showed that the 1513C allele, acting dominantly, is a possible risk factor for clinical TB, whereas the -762 P2RX7 polymorphism did not appear to be associated with human susceptibility to TB.
|
18436590 |
2008 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To determine if polymorphisms in P2X7 are associated with increased risk of TB, the prevalence of four polymorphisms was assessed in individuals from Southeast Asia, where the majority of patients with TB in our study originate.
|
17095747 |
2007 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Five single-nucleotide polymorphisms (SNPs) previously identified in a putative 1.8-kb promoter region upstream of P2RX7 exon 1 were screened for associations with clinical tuberculosis.
|
12404161 |
2002 |