|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Additionally, recent studies have linked P2RX7 gene variants with the risk of rapid cycling in clinical cohorts of patients with bipolar disorder, as well as other mood disorders.
|
30445384 |
2019 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The Gln460Arg (rs2230912) polymorphism of the P2RX7 gene has been widely studied in mood disorders, however the results are still controversial.
|
30664971 |
2019 |
|
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
We also highlight recent advances in drug discovery and development of P2X7 small molecule antagonists and P2X7 PET ligands which provide optimism that clinical tools are availableto address critical proof-of-concept experiments in mood disorders.
|
30121550 |
2018 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Various studies have investigated whether single nucleotide polymorphisms (SNPs) in the gene purinergic receptor P2X7 (P2RX7), and rs2230912 specifically, were associated with mood disorders.
|
29122639 |
2018 |
|
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
In this review, we will discuss the recent progress in understanding the role of the P2X7 receptor in the pathogenesis and development of mood disorders and in discovering CNS-penetrable P2X7 antagonists for potential uses in in vivo imaging to monitor brain inflammation and antidepressant therapeutics.
|
29453990 |
2018 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
These results indicate that heterozygosity for the wild-type P2X7R and its mood disorder-associated variant P2X7R-Gln460Arg represents a genetic risk factor, which is potentially able to convey susceptibility to mood disorders.<b>SIGNIFICANCE STATEMENT</b> Depression and bipolar disorder are the most common mood disorders.
|
29079688 |
2017 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Overall, our meta-analysis suggests that P2RX7 gene rs2230912 polymorphism may not contribute to the risk of developing mood disorders using a case-control design.
|
24533115 |
2014 |
|
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
Overall, our meta-analysis suggests that P2RX7 gene rs2230912 polymorphism may not contribute to the risk of developing mood disorders using a case-control design.
|
24533115 |
2014 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In the current study the genetic effects of rs2230912 (Gln460Arg) and rs1653625 (located in the 3' untranslated region of the P2RX7 gene) were explored in mood disorders.
|
23602648 |
2013 |
|
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
In the current study the genetic effects of rs2230912 (Gln460Arg) and rs1653625 (located in the 3' untranslated region of the P2RX7 gene) were explored in mood disorders.
|
23602648 |
2013 |
|
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
Here, we test whether the personality trait neuroticism mediates the effect of P2RX7 on the course of mood disorders.
|
22623165 |
2012 |
|
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
This supports earlier findings of P2RX7 associations to affective disorder and is in agreement with that particularly rapid cycling patients have a more vulnerable diurnal system.
|
22952630 |
2012 |
|
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
This supports earlier findings of P2RX7 associations to affective disorder and is in agreement with that particularly rapid cycling patients have a more vulnerable diurnal system.
|
22952630 |
2012 |
|
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
Among P2X receptors, the P2X7 receptor (P2rx7) has received considerable interest in both basic and clinical neuropsychiatric research because of its profound effects in animal CNS pathology and its potential involvement as a susceptibility gene in mood disorders.
|
23269209 |
2012 |
|
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Here, we test whether the personality trait neuroticism mediates the effect of P2RX7 on the course of mood disorders.
|
22623165 |
2012 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The same risk alleles predicted more time ill in all cohorts (OR 1.3, 95% CI 1.1-1.6, P = 0.0069 and OR 1.7, 95% CI 1.3-2.3, P = 0.0002 with rs208294 and rs2230912, respectively), so that homozygous carriers spent 12 and 24% more time ill. P2RX7 and its risk alleles predisposed to mood disorders consistently in three independent clinical cohorts.
|
21438144 |
2011 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Additional studies are needed to clarify the potential involvement of P2RX7 and of SNP rs2230912 in the etiology of major affective disorders.
|
19330776 |
2009 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
When we combined these data with the published case-control studies of P2RX7 and mood disorder (3586 individuals) the association between rs2230912 (Gln460Arg) and affective disorders became more robust (P=0.002).
|
18268501 |
2009 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our data do not provide support for rs2230912 or the other polymorphisms studied within the P2RX7 locus, being involved in susceptibility to mood disorders.
|
19160446 |
2009 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms in the P2X7 gene that modify operation of the regenerative loop or the release of cytokines, as can infections, change the functional state of neural networks, which may then lead to vulnerability to mood disorders.
|
17558618 |
2007 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The P2RX7 gene is located within a region on chromosome 12q24.31 that has been identified as a susceptibility locus for affective disorders by linkage and association studies.
|
16822851 |
2006 |